Jesus Torres Vazquez

Jesus Torres Vazquez, PhD

Skirball Institute

Associate Professor, Department of Cell Biology

Keywords
Biochemistry, Cellular Dynamics, Confocal Microscopy, Genetics, In vivo imaging, Vascular Biology, Zebrafish
Summary

Sculpture lessons: how the zebrafish shapes its vessels

The vasculature delivers nutrients, gases, hormones and immunity factors throughout the body, allowing cells, tissues and organs to thrive. For blood and lymphatic vessels to function properly, endothelial cords must be positioned correctly, form with sufficient abundance, acquire the proper shape and size, transform into functional tubes and adopt cellular and molecular characteristics suited to their organ environments.

Research in the lab currently focuses on these topics:

(1) How do vascular sprouts form with the proper abundance, positioning, and shape?

(2) How is the brain vascularized and how does the Blood Brain Barrier form?

(3) Novel mechanisms of vessel formation

Model systems used in the lab:

To understand the molecular and cellular mechanisms involved in vascular organogenesis we exploit the complementary advantages of the transparent zebrafish embryo and cultured endothelial cells as model systems for vascular development.

Common techniques employed in the lab:

Confocal imaging of transgenic animals carrying endothelial-specific fluorescent reporters, analysis of gene expression, forced gene expression, transgenesis, genome editing, cell transplantation, cell culture, and biochemistry.

Phone

212-263-0298

Fax

212-263-7769

Academic office

540 First Avenue

Fourth Floor, Lab 14

New York, NY 10016

Lab Website
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Associate Professor, Department of Cell Biology

PhD from University of California, Irvine

National Institutes of Health, Section on Vertebrate Organogenesis

Shang, Guijun; Brautigam, Chad A; Chen, Rui; Lu, Defen; Torres-Vazquez, Jesus; Zhang, Xuewu

eLife. 2017 May 24; 6:?-?

Castranova, Daniel; Davis, Andrew E; Lo, Brigid D; Miller, Mayumi F; Paukstelis, Paul J; Swift, Matthew R; Pham, Van N; Torres-Vazquez, Jesus; Bell, Kameha; Shaw, Kenna M; Kamei, Makoto; Weinstein, Brant M

Arteriosclerosis, thrombosis, & vascular biology. 2016 Apr; 36(4):655-662

Ulrich, Florian; Carretero-Ortega, Jorge; Menendez, Javier; Narvaez, Carlos; Sun, Belinda; Lancaster, Eva; Pershad, Valerie; Trzaska, Sean; Veliz, Evelyn; Kamei, Makoto; Prendergast, Andrew; Kidd, Kameha R; Shaw, Kenna M; Castranova, Daniel A; Pham, Van N; Lo, Brigid D; Martin, Benjamin L; Raible, David W; Weinstein, Brant M; Torres-Vazquez, Jesus

Development. 2016 Mar 15; 143(6):1055-1055

Ulrich, Florian; Carretero-Ortega, Jorge; Menendez, Javier; Narvaez, Carlos; Sun, Belinda; Lancaster, Eva; Pershad, Valerie; Trzaska, Sean; Veliz, Evelyn; Kamei, Makoto; Prendergast, Andrew; Kidd, Kameha R; Shaw, Kenna M; Castranova, Daniel A; Pham, Van N; Lo, Brigid D; Martin, Benjamin L; Raible, David W; Weinstein, Brant M; Torres-Vazquez, Jesus

Development. 2016 Jan 01; 143(1):147-159

Nagelberg, Danielle; Wang, Jinhu; Su, Rina; Torres-Vazquez, Jesus; Targoff, Kimara L; Poss, Kenneth D; Knaut, Holger

Current biology. CB. 2015 Aug 17; 25(16):2099-2110

Minchin, James E N; Dahlman, Ingrid; Harvey, Christopher J; Mejhert, Niklas; Singh, Manvendra K; Epstein, Jonathan A; Arner, Peter; Torres-Vazquez, Jesus; Rawls, John F

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 Apr 07; 112(14):4363-4368

Fang, Fang; Wasserman, Scott M; Torres-Vazquez, Jesus; Weinstein, Brant; Cao, Feng; Li, Zongjin; Wilson, Kitchener D; Yue, Wen; Wu, Joseph C; Xie, Xiaoyan; Pei, Xuetao

Journal of cell science. 2014 Apr 01; 127(Pt 7):1428-1440