Jonas Schluter

Jonas Schluter, PhD

Institute for Systems Genetics

Assistant Professor, Department of Microbiology

Keywords
gut microbiome, massive clinical data sets and the hospitalome, microbial ecology and warfare, evolutionary theory, quorum sensing, machine-learning and Bayesian time series analysis, microbiota, cancer, immunity, immunology
Summary

We seek to leverage the human microbiota as a therapeutic target of the future. We approach this ambitious goal from two opposing directions: on the one end, we utilize massive datasets to detect temporal associations between the gut microbiota and the body, with particular emphasis on immune homeostasis; on the other end, we are developing fundamental theory of host-microbiota evolution and ecology. Theory and large-scale data analysis inform our microbiota community experiments, focusing on anaerobic cultivation techniques, that ultimately lead to interventional trials of microbiota-targeted therapies. Specifically, we are leveraging the arsenal of microbial warfare to control complex microbial ecosystems.

Phone

212-263-6973

Academic office

435 East 30th Street, Science Building

8th floor, SB815

New York City, NY 10016

Lab Website
Schluter Lab
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Positions

Assistant Professor, Department of Microbiology at NYU Grossman School of Medicine

Graduate Education

PhD from Oxford University Medical School

Postdoctoral Training

Memorial Sloan Kettering Cancer Center, Xavier Lab / Computational Biology Group

Role of the oral cavity in inflammatory bowel disease

See All Studies (1)

Diverse phage communities are maintained stably on a clonal bacterial host

Pyenson, Nora C; Leeks, Asher; Nweke, Odera; Goldford, Joshua E; Schluter, Jonas; Turner, Paul E; Foster, Kevin R; Sanchez, Alvaro

Science. 2024 Dec 13; 386(6727):1294-1300

The gut microbiota is associated with immune cell dynamics in humans

Schluter, Jonas; Peled, Jonathan U; Taylor, Bradford P; Markey, Kate A; Smith, Melody; Taur, Ying; Niehus, Rene; Staffas, Anna; Dai, Anqi; Fontana, Emily; Amoretti, Luigi A; Wright, Roberta J; Morjaria, Sejal; Fenelus, Maly; Pessin, Melissa S; Chao, Nelson J; Lew, Meagan; Bohannon, Lauren; Bush, Amy; Sung, Anthony D; Hohl, Tobias M; Perales, Miguel-Angel; van den Brink, Marcel R M; Xavier, Joao B

Nature. 2020 Dec; 588(7837):303-307

The ecology of the microbiome: Networks, competition, and stability

Coyte, Katharine Z; Schluter, Jonas; Foster, Kevin R

Science. 2015 Nov 06; 350(6261):663-6

The TaxUMAP atlas: Efficient display of large clinical microbiome data reveals ecological competition in protection against bacteremia

Schluter, Jonas; Djukovic, Ana; Taylor, Bradford P; Yan, Jinyuan; Duan, Caichen; Hussey, Grant A; Liao, Chen; Sharma, Sneh; Fontana, Emily; Amoretti, Luigi A; Wright, Roberta J; Dai, Anqi; Peled, Jonathan U; Taur, Ying; Perales, Miguel-Angel; Siranosian, Benjamin A; Bhatt, Ami S; van den Brink, Marcel R M; Pamer, Eric G; Xavier, Joao B

Cell host & microbe. 2023 Jul 12; 31(7):1126-1139.e6

Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy

Smith, Melody; Dai, Anqi; Ghilardi, Guido; Amelsberg, Kimberly V; Devlin, Sean M; Pajarillo, Raymone; Slingerland, John B; Beghi, Silvia; Herrera, Pamela S; Giardina, Paul; Clurman, Annelie; Dwomoh, Emmanuel; Armijo, Gabriel; Gomes, Antonio L C; Littmann, Eric R; Schluter, Jonas; Fontana, Emily; Taur, Ying; Park, Jae H; Palomba, Maria Lia; Halton, Elizabeth; Ruiz, Josel; Jain, Tania; Pennisi, Martina; Afuye, Aishat Olaide; Perales, Miguel-Angel; Freyer, Craig W; Garfall, Alfred; Gier, Shannon; Nasta, Sunita; Landsburg, Daniel; Gerson, James; Svoboda, Jakub; Cross, Justin; Chong, Elise A; Giralt, Sergio; Gill, Saar I; Riviere, Isabelle; Porter, David L; Schuster, Stephen J; Sadelain, Michel; Frey, Noelle; Brentjens, Renier J; June, Carl H; Pamer, Eric G; Peled, Jonathan U; Facciabene, Andrea; van den Brink, Marcel R M; Ruella, Marco

Nature medicine. 2022 Apr; 28(4):713-723

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes

Schulfer, Anjelique F; Schluter, Jonas; Zhang, Yilong; Brown, Quincy; Pathmasiri, Wimal; McRitchie, Susan; Sumner, Susan; Li, Huilin; Xavier, Joao B; Blaser, Martin J

ISME journal. 2019 May; 13(5):1280-1292

Microbe-derived short chain fatty acids butyrate and propionate are associated with protection from chronic GVHD

Markey, Kate A; Schluter, Jonas; Gomes, Antonio Lc; Littmann, Eric; Pickard, Amanda; Taylor, Bradford P; Giardina, Paul A; Weber, Daniela; Dai, Anqi; Docampo, Melissa; Armijo, Gabriel K; Slingerland, Ann; Slingerland, John; Nichols, Katherine B; Brereton, Daniel G; Clurman, Annelie; Ramos, Ruben J; Rao, Arka; Bush, Amy T; Bohannon, Lauren; Covington, Megan; Lew, Meagan V; Rizzieri, David A; Chao, Nelson J; Maloy, Molly; Cho, Christina; Politikos, Ioannis; Giralt, Sergio; Taur, Ying; Pamer, Eric; Holler, Ernst; Perales, Miguel-Angel; Ponce, Doris M; Devlin, Sean M; Xavier, Joao; Sung, Anthony; Peled, Jonathan U; Cross, Justin R; van den Brink, Marcel Rm

Blood. 2020 Jul 02; 136(1):130-136

Review and revamp of compositional data transformation: A new framework combining proportion conversion and contrast transformation

Zhang, Yiqian; Schluter, Jonas; Zhang, Lijun; Cao, Xuan; Jenq, Robert R; Feng, Hao; Haines, Jonathan; Zhang, Liangliang

Computational & structural biotechnology journal. 2024 Dec; 23:4088-4107

See All Publications (28)

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