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Jonas Schluter, PhD

Institute for Computational Medicine

Assistant Professor, Department of Microbiology

gut microbiome, massive clinical data sets and the hospitalome, microbial ecology and warfare, evolutionary theory, quorum sensing, machine-learning and Bayesian time series analysis

We seek to leverage the human microbiota as a therapeutic target of the future. We approach this ambitious goal from two opposing directions: on the one end, we utilize massive datasets to detect temporal associations between the gut microbiota and the body, with particular emphasis on immune homeostasis; on the other end, we are developing fundamental theory of host-microbiota evolution and ecology. Theory and large-scale data analysis inform our microbiota community experiments, focusing on anaerobic cultivation techniques, that ultimately lead to interventional trials of microbiota-targeted therapies. Specifically, we are leveraging the arsenal of microbial warfare, including quorum sensing, and other products of microbial metabolism to steer complex microbial ecosystems.

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PhD from University of Oxford

Coyte, Katharine Z; Schluter, Jonas; Foster, Kevin R

Science. 2015 Nov 06; 350(6261):663-6

Foster, Kevin R; Schluter, Jonas; Coyte, Katharine Z; Rakoff-Nahoum, Seth

Nature. 2017 08 02; 548(7665):43-51

Taur, Ying; Coyte, Katharine; Schluter, Jonas; Robilotti, Elizabeth; Figueroa, Cesar; Gjonbalaj, Mergim; Littmann, Eric R; Ling, Lilan; Miller, Liza; Gyaltshen, Yangtsho; Fontana, Emily; Morjaria, Sejal; Gyurkocza, Boglarka; Perales, Miguel-Angel; Castro-Malaspina, Hugo; Tamari, Roni; Ponce, Doris; Koehne, Guenther; Barker, Juliet; Jakubowski, Ann; Papadopoulos, Esperanza; Dahi, Parastoo; Sauter, Craig; Shaffer, Brian; Young, James W; Peled, Jonathan; Meagher, Richard C; Jenq, Robert R; van den Brink, Marcel R M; Giralt, Sergio A; Pamer, Eric G; Xavier, Joao B

Science translational medicine. 2018 09 26; 10(460):

Morjaria, Sejal; Schluter, Jonas; Taylor, Bradford P; Littmann, Eric R; Carter, Rebecca A; Fontana, Emily; Peled, Jonathan U; van den Brink, Marcel R M; Xavier, Joao B; Taur, Ying

Infection & immunity. 2019 09; 87(9):

McLoughlin, Kirstie; Schluter, Jonas; Rakoff-Nahoum, Seth; Smith, Adrian L; Foster, Kevin R

Cell host & microbe. 2016 Apr 13; 19(4):550-9

Schluter, Jonas; Schoech, Armin P; Foster, Kevin R; Mitri, Sara

PLoS computational biology. 2016 04; 12(4):e1004848

Schluter, Jonas; Nadell, Carey D; Bassler, Bonnie L; Foster, Kevin R

ISME journal. 2015 Jan; 9(1):139-49

Markey, Kate A; Schluter, Jonas; Gomes, Antonio Lc; Littmann, Eric; Pickard, Amanda; Taylor, Bradford P; Giardina, Paul A; Weber, Daniela; Dai, Anqi; Docampo, Melissa; Armijo, Gabriel K; Slingerland, Ann; Slingerland, John; Nichols, Katherine B; Brereton, Daniel G; Clurman, Annelie; Ramos, Ruben J; Rao, Arka; Bush, Amy T; Bohannon, Lauren; Covington, Megan; Lew, Meagan V; Rizzieri, David A; Chao, Nelson J; Maloy, Molly; Cho, Christina; Politikos, Ioannis; Giralt, Sergio; Taur, Ying; Pamer, Eric; Holler, Ernst; Perales, Miguel-Angel; Ponce, Doris M; Devlin, Sean M; Xavier, Joao; Sung, Anthony; Peled, Jonathan U; Cross, Justin R; van den Brink, Marcel Rm

Blood. 2020 Jul 02; 136(1):130-136