Skip to Main Content

Jonas Schluter, PhD

Institute for Computational Medicine

Assistant Professor, Department of Microbiology

Keywords
gut microbiome, massive clinical data sets and the hospitalome, microbial ecology and warfare, evolutionary theory, quorum sensing, machine-learning and Bayesian time series analysis
Summary

We seek to leverage the human microbiota as a therapeutic target of the future. We approach this ambitious goal from two opposing directions: on the one end, we utilize massive datasets to detect temporal associations between the gut microbiota and the body, with particular emphasis on immune homeostasis; on the other end, we are developing fundamental theory of host-microbiota evolution and ecology. Theory and large-scale data analysis inform our microbiota community experiments, focusing on anaerobic cultivation techniques, that ultimately lead to interventional trials of microbiota-targeted therapies. Specifically, we are leveraging the arsenal of microbial warfare, including quorum sensing, and other products of microbial metabolism to steer complex microbial ecosystems.

Is this your profile?

PhD from University of Oxford

Coyte, Katharine Z; Schluter, Jonas; Foster, Kevin R

Science. 2015 Nov 06; 350(6261):663-6

Foster, Kevin R; Schluter, Jonas; Coyte, Katharine Z; Rakoff-Nahoum, Seth

Nature. 2017 08 02; 548(7665):43-51

Taur, Ying; Coyte, Katharine; Schluter, Jonas; Robilotti, Elizabeth; Figueroa, Cesar; Gjonbalaj, Mergim; Littmann, Eric R; Ling, Lilan; Miller, Liza; Gyaltshen, Yangtsho; Fontana, Emily; Morjaria, Sejal; Gyurkocza, Boglarka; Perales, Miguel-Angel; Castro-Malaspina, Hugo; Tamari, Roni; Ponce, Doris; Koehne, Guenther; Barker, Juliet; Jakubowski, Ann; Papadopoulos, Esperanza; Dahi, Parastoo; Sauter, Craig; Shaffer, Brian; Young, James W; Peled, Jonathan; Meagher, Richard C; Jenq, Robert R; van den Brink, Marcel R M; Giralt, Sergio A; Pamer, Eric G; Xavier, Joao B

Science translational medicine. 2018 09 26; 10(460):

Morjaria, Sejal; Schluter, Jonas; Taylor, Bradford P; Littmann, Eric R; Carter, Rebecca A; Fontana, Emily; Peled, Jonathan U; van den Brink, Marcel R M; Xavier, Joao B; Taur, Ying

Infection & immunity. 2019 09; 87(9):

McLoughlin, Kirstie; Schluter, Jonas; Rakoff-Nahoum, Seth; Smith, Adrian L; Foster, Kevin R

Cell host & microbe. 2016 Apr 13; 19(4):550-9

Schluter, Jonas; Schoech, Armin P; Foster, Kevin R; Mitri, Sara

PLoS computational biology. 2016 04; 12(4):e1004848

Schluter, Jonas; Nadell, Carey D; Bassler, Bonnie L; Foster, Kevin R

ISME journal. 2015 Jan; 9(1):139-49

Markey, Kate A; Schluter, Jonas; Gomes, Antonio Lc; Littmann, Eric; Pickard, Amanda; Taylor, Bradford P; Giardina, Paul A; Weber, Daniela; Dai, Anqi; Docampo, Melissa; Armijo, Gabriel K; Slingerland, Ann; Slingerland, John; Nichols, Katherine B; Brereton, Daniel G; Clurman, Annelie; Ramos, Ruben J; Rao, Arka; Bush, Amy T; Bohannon, Lauren; Covington, Megan; Lew, Meagan V; Rizzieri, David A; Chao, Nelson J; Maloy, Molly; Cho, Christina; Politikos, Ioannis; Giralt, Sergio; Taur, Ying; Pamer, Eric; Holler, Ernst; Perales, Miguel-Angel; Ponce, Doris M; Devlin, Sean M; Xavier, Joao; Sung, Anthony; Peled, Jonathan U; Cross, Justin R; van den Brink, Marcel Rm

Blood. 2020 Jul 02; 136(1):130-136