Jose Gabriel Barcia Duran

Jose Gabriel Barcia Duran, PhD

Research Instructor, Department of Medicine

Keywords
cardiovascular biology, immunology, inflammation
Summary

My research is based on understanding intrinsic and non-cell-autonomous processes governing immune cell ontogeny and function, both at steady state and in cardiovascular disease. This work has revealed novel cell-extrinsic mechanisms through which immune cells, their progenitors, and the vasculature interact and has provided tractable platforms for the study of vasculopathies, inflammatory conditions, and cancer.

Currently, my research is focused on immune cell function in atherosclerosis. The atherosclerotic plaque forms when lipid and immune cell accumulation along the artery wall progress without restraint, which happens to most if not all of the population as we age. While some plaques may be stable, the rupture of any one plaque can bring about serious cardiovascular events like myocardial infarction or stroke. Among the many immune cell types involved, macrophages are innately equipped to resolve the inflammatory processes that promote plaque progression and rupture. My approach relies on both genomic and genetic tools to reconstruct the transcriptional and proteomic landscape of atherosclerotic plaque leukocytes, identify pro-resolving macrophage signaling networks, and develop highly specific anti-inflammatory therapies to treat and prevent atherosclerosis.

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PhD from Cornell University

Cappelli, Luca Vincenzo; Fiore, Danilo; Phillip, Jude M; Yoffe, Liron; Di Giacomo, Filomena; Chiu, William; Hu, Yang; Kayembe, Clarisse; Ginsberg, Michael; Consolino, Lorena; Barcia Durán, José Gabriel; Zamponi, Nahuel; Melnick, Ari M; Boccalatte, Francesco; Tam, Wayne; Elemento, Olivier; Chiaretti, Sabina; Guarini, Anna Rita; Foà, Robin; Cerchietti, Leandro; Rafii, Shahin; Inghirami, Giorgio Ga

Blood. 2023 Feb 02; 141(5):503-518

Guo, Peipei; Liu, Ying; Geng, Fuqiang; Daman, Andrew W; Liu, Xiaoyu; Zhong, Liangwen; Ravishankar, Arjun; Lis, Raphael; Barcia Durán, José Gabriel; Itkin, Tomer; Tang, Fanying; Zhang, Tuo; Xiang, Jenny; Shido, Koji; Ding, Bi-Sen; Wen, Duancheng; Josefowicz, Steven Z; Rafii, Shahin

Nature cell biology. 2022 Feb; 24(2):279

Guo, Peipei; Liu, Ying; Geng, Fuqiang; Daman, Andrew W; Liu, Xiaoyu; Zhong, Liangwen; Ravishankar, Arjun; Lis, Raphael; Barcia Durán, José Gabriel; Itkin, Tomer; Tang, Fanying; Zhang, Tuo; Xiang, Jenny; Shido, Koji; Ding, Bi-Sen; Wen, Duancheng; Josefowicz, Steven Z; Rafii, Shahin

Nature cell biology. 2022 Jan; 24(1):99-111

Barcia Durán, José Gabriel; Lu, Tyler; Houghton, Sean; Geng, Fuqiang; Schreiner, Ryan; Xiang, Jenny; Rafii, Shahin; Redmond, David; Lis, Raphaël

Communications biology. 2021 Mar 25; 4(1):406

Lu, Tyler M; Houghton, Sean; Magdeldin, Tarig; Durán, José Gabriel Barcia; Minotti, Andrew P; Snead, Amanda; Sproul, Andrew; Nguyen, Duc-Huy T; Xiang, Jenny; Fine, Howard A; Rosenwaks, Zev; Studer, Lorenz; Rafii, Shahin; Agalliu, Dritan; Redmond, David; Lis, Raphaël

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2021 Feb 23; 118(8):

Lu, Tyler M; Barcia Durán, José Gabriel; Houghton, Sean; Rafii, Shahin; Redmond, David; Lis, Raphaël

Frontiers in physiology. 2021; 12:642812

Barcia Durán, José Gabriel; Lis, Raphaël; Rafii, Shahin

FEBS letters. 2019 Dec; 593(23):3253-3265

Barcia Durán, José Gabriel; Lis, Raphaël; Lu, Tyler M; Rafii, Shahin

Nature protocols. 2018 Dec; 13(12):2758-2780