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Ju-Hyun Lee

Research Assistant Professor, Department of Psychiatry

Positions

Research Assistant Professor, Department of Psychiatry at NYU Grossman School of Medicine

Phone

845-398-5438

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Academic office

140 Old Orangeburg Road

L103

Orangeburg, NY 10962

Autophagy is a novel pathway for neurofilament protein degradation in vivo

Rao, Mala V; Darji, Sandipkumar; Stavrides, Philip H; Goulbourne, Chris N; Kumar, Asok; Yang, Dun-Sheng; Yoo, Lang; Peddy, James; Lee, Ju-Hyun; Yuan, Aidong; Nixon, Ralph A

Autophagy. 2022 Sep 21; 1-16

Autolysosomal acidification failure as a primary driver of Alzheimer disease pathogenesis

Lee, Ju-Hyun; Nixon, Ralph A

Autophagy. 2022 Aug 23; 1-2

Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

Lee, Ju-Hyun; Yang, Dun-Sheng; Goulbourne, Chris N; Im, Eunju; Stavrides, Philip; Pensalfini, Anna; Chan, Han; Bouchet-Marquis, Cedric; Bleiwas, Cynthia; Berg, Martin J; Huo, Chunfeng; Peddy, James; Pawlik, Monika; Levy, Efrat; Rao, Mala; Staufenbiel, Mathias; Nixon, Ralph A

Nature neuroscience. 2022 Jun; 25(6):688-701

Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca2+ efflux and disrupted by PSEN1 loss of function

Lie, Pearl P Y; Yoo, Lang; Goulbourne, Chris N; Berg, Martin J; Stavrides, Philip; Huo, Chunfeng; Lee, Ju-Hyun; Nixon, Ralph A

Science advances. 2022 Apr 29; 8(17):eabj5716

Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease

Pensalfini, Anna; Kim, Seonil; Subbanna, Shivakumar; Bleiwas, Cynthia; Goulbourne, Chris N; Stavrides, Philip H; Jiang, Ying; Lee, Ju-Hyun; Darji, Sandipkumar; Pawlik, Monika; Huo, Chunfeng; Peddy, James; Berg, Martin J; Smiley, John F; Basavarajappa, Balapal S; Nixon, Ralph A

Cell reports. 2020 Nov 24; 33(8):108420

β2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of ClC-7

Lee, Ju-Hyun; Wolfe, Devin M; Darji, Sandipkumar; McBrayer, Mary Kate; Colacurcio, Daniel J; Kumar, Asok; Stavrides, Philip; Mohan, Panaiyur S; Nixon, Ralph A

Journal of molecular biology. 2020 Apr 03; 432(8):2633-2650

Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo

Lee, Ju-Hyun; Rao, Mala V; Yang, Dun-Sheng; Stavrides, Philip; Im, Eunju; Pensalfini, Anna; Huo, Chunfeng; Sarkar, Pallabi; Yoshimori, Tamotsu; Nixon, Ralph A

Autophagy. 2019 Mar; 15(3):543-557

Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

Lee, Ju-Hyun; McBrayer, Mary Kate; Wolfe, Devin M; Haslett, Luke J; Kumar, Asok; Sato, Yutaka; Lie, Pearl P Y; Mohan, Panaiyur; Coffey, Erin E; Kompella, Uday; Mitchell, Claire H; Lloyd-Evans, Emyr; Nixon, Ralph A

Cell reports. 2015 Sep 01; 12(9):1430-44

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