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Jun Wang

Jun Wang, PhD

Assistant Professor, Department of Pathology


Dr. Jun Wang is currently an assistant professor at Department of Pathology and the Laura and Isaac Perlmutter Cancer Center of NYU Langone health who has been working on cancer immunology and immunotherapy for over fifteen years. He finished his postdoctoral research in Dr. Lieping Chen’s laboratory at Johns Hopkins Medicine and the Yale Department of Immunobiology. His research interest lies in discovering and understanding novel receptor-ligand pathways with immune-modulatory functions and how to best utilize them as potential targets for cancer immunotherapy. During these years, Dr. Wang developed several genome-scale proprietary screening platforms leading to valuable industrial partnerships, some of which formed the basis of NextCure, Inc. He has discovered several first-in-class targets, such as FGL1/LAG-3 and Siglec-15, which represent novel tumor immune evasion mechanisms and new approaches for cancer immunotherapy. The first-in-human cancer clinical trials targeting the Siglec-15 pathway are currently ongoing at Yale and NYU, in addition to other sites. Moreover, Dr. Wang also examined the mechanisms of anti-tumor efficacy versus liver toxicity of agonistic anti-CD137 (4-1BB) therapy and provided new insights for alleviating liver pathology without disruption of anti-tumor immunity.Moving forward, Dr. Wang is planning to use innovative technologies to identify key mechanisms within the tumor microenvironment in the control of anti-tumor immunity and to design useful next-generation cancer immunotherapies with rational biomarkers.



Academic office

550 First Ave, Smilow Research Building


New York, NY 10016

Lab Website
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PhD from Chinese Academy of Sciences

Yale University, Cancer Immunology and Immunotherapy

Chen, Xufeng; Lu, Qiao; Zhou, Hua; Liu, Jia; Nadorp, Bettina; Lasry, Audrey; Sun, Zhengxi; Lai, Baoling; Rona, Gergely; Zhang, Jiangyan; Cammer, Michael; Wang, Kun; Al-Santli, Wafa; Ciantra, Zoe; Guo, Qianjin; You, Jia; Sengupta, Debrup; Boukhris, Ahmad; Zhang, Hongbing; Liu, Cheng; Cresswell, Peter; Dahia, Patricia L M; Pagano, Michele; Aifantis, Iannis; Wang, Jun

Cell. 2023 Aug 31; 186(18):3903-3920.e21

Melero, Ignacio; Sanmamed, Miguel F; Glez-Vaz, Javier; Luri-Rey, Carlos; Wang, Jun; Chen, Lieping

Cancer discovery. 2023 Mar 01; 13(3):552-569

Li, Long; Durand-de Cuttoli, Romain; Aubry, Antonio V; Burnett, C Joseph; Cathomas, Flurin; Parise, Lyonna F; Chan, Kenny L; Morel, Carole; Yuan, Chongzhen; Shimo, Yusuke; Lin, Hsiao-Yun; Wang, Jun; Russo, Scott J

Nature. 2023 Jan; 613(7945):696-703

Xie, Wenqiang; Fang, Juan; Shan, Zhongyan; Guo, Junyi; Liao, Yuan; Zou, Zhaolei; Wang, Jun; Wen, Shuqiong; Yang, Lisa; Zhang, Yanshu; Lu, Huanzi; Zhao, Hang; Kuang, Dong-Ming; Huang, Peng; Chen, Qianming; Wang, Zhi

Science advances. 2022 Sep 30; 8(39):eabo4250

Shu, Fei; Punekar, Salman R; Velcheti, Vamsidhar; Sanmamed, Miguel F; Wang, Jun

Clinical cancer research. 2022 Aug 02; 28(15):3182-3184

Gomez, Kimberly; Tang, Cheng; Tan, Bin; Perez-Miller, Samantha; Ran, Dongzhi; Loya, Santiago; Calderon-Rivera, Aida; Stratton, Harrison J; Duran, Paz; Masterson, Kyleigh A; Gabrielsen, Anna T; Alsbiei, Omar; Dorame, Angie; Serafini, Maria; Moutal, Aubin; Wang, Jun; Khanna, Rajesh

ACS chemical neuroscience. 2022 Jul 06; 13(13):2035-2047

Barrett, Tessa J; Bilaloglu, Seda; Cornwell, Macintosh; Burgess, Hannah M; Virginio, Vitor W; Drenkova, Kamelia; Ibrahim, Homam; Yuriditsky, Eugene; Aphinyanaphongs, Yin; Lifshitz, Mark; Xia Liang, Feng; Alejo, Julie; Smith, Grace; Pittaluga, Stefania; Rapkiewicz, Amy V; Wang, Jun; Iancu-Rubin, Camelia; Mohr, Ian; Ruggles, Kelly; Stapleford, Kenneth A; Hochman, Judith; Berger, Jeffrey S

Journal of thrombosis & haemostasis : JTH. 2021 Dec; 19(12):3139-3153

Gu, Runxia; Mao, Tianyang; Lu, Qiao; Tianjiao Su, Tina; Wang, Jun

Seminars in immunology. 2021 Nov 09; 101524