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Jun Wang, PhD

Assistant Professor, Department of Pathology

Summary

Dr. Jun Wang is currently an assistant professor at Department of Pathology and the Laura and Isaac Perlmutter Cancer Center of NYU Langone health who has been working on cancer immunology and immunotherapy for over fifteen years. He finished his postdoctoral research in Dr. Lieping Chen’s laboratory at Johns Hopkins Medicine and the Yale Department of Immunobiology. His research interest lies in discovering and understanding novel receptor-ligand pathways with immune-modulatory functions and how to best utilize them as potential targets for cancer immunotherapy. During these years, Dr. Wang developed several genome-scale proprietary screening platforms leading to valuable industrial partnerships, some of which formed the basis of NextCure, Inc. He has discovered several first-in-class targets, such as FGL1/LAG-3 and Siglec-15, which represent novel tumor immune evasion mechanisms and new approaches for cancer immunotherapy. The first-in-human cancer clinical trials targeting the Siglec-15 pathway are currently ongoing at Yale and NYU, in addition to other sites. Moreover, Dr. Wang also examined the mechanisms of anti-tumor efficacy versus liver toxicity of agonistic anti-CD137 (4-1BB) therapy and provided new insights for alleviating liver pathology without disruption of anti-tumor immunity.Moving forward, Dr. Wang is planning to use innovative technologies to identify key mechanisms within the tumor microenvironment in the control of anti-tumor immunity and to design useful next-generation cancer immunotherapies with rational biomarkers.

Phone

212-263-1506

Academic office

550 First Ave, Smilow Research Building

316

New York, NY 10016

Lab Website
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PhD from Chinese Academy of Sciences

Yale University, Cancer Immunology and Immunotherapy

Zhou, Ting; Su, Tina Tianjiao; Mudianto, Tenny; Wang, Jun

Journal of experimental medicine. 2020 10 05; 217(10):

Zhou, Ting; Damsky, William; Weizman, Orr-El; McGeary, Meaghan K; Hartmann, K Patricia; Rosen, Connor E; Fischer, Suzanne; Jackson, Ruaidhri; Flavell, Richard A; Wang, Jun; Sanmamed, Miguel F; Bosenberg, Marcus W; Ring, Aaron M

Nature. 2020 Jul; 583(7817):609-614

Wang, Fang; Jin, Jin; Wang, Jun; He, Ruoqiao; Li, Kaiyun; Hu, Xiaonan; Li, Yongchao; Zhu, Yuncheng

Scientific reports. 2020 Apr 14; 10(1):6322

Chen, Yichen; Wang, Jun; Wang, Xi; Li, Xinye; Song, Jingjing; Fang, Juan; Liu, Xiangqi; Liu, Tao; Wang, Dikan; Li, Qunxing; Wen, Shuqiong; Ma, Da; Xia, Juan; Luo, Liqun; Zheng, Song Guo; Cui, Jun; Zeng, Gucheng; Chen, Lieping; Cheng, Bin; Wang, Zhi

Clinical cancer research. 2019 Oct 15; 25(20):6180-6194

Datar, Ila J; Sanmamed, Miguel F; Wang, Jun; Henick, Brian S; Choi, Jungmin; Badri, Ti; Dong, Weilai; Mani, Nikita; Toki, Maria I; Mejías, Luis; Lozano, Maria D; Perez-Gracia, Jose Luis; Velcheti, Vamsidhar; Hellmann, Matthew D; Gainor, Justin F; McEachern, Kristen; Jenkins, David; Syrigos, Konstantinos N; Politi, Katerina; Gettinger, Scott; Rimm, David L; Herbst, Roy S; Melero, Ignacio; Chen, Lieping; Schalper, Kurt A

Clinical cancer research. 2019 Aug 01; 25(15):4663-4673

Liu, Di; Lu, Qian; Wang, Xing; Wang, Jun; Lu, Ning; Jiang, Zefei; Hao, Xiaopeng; Li, Jianbin; Liu, Jing; Cao, Pengbo; Peng, Guilin; Tao, Yuandong; Zhao, Dianyuan; He, Fuchu; Tang, Li

Cell research. 2019 May; 29(5):365-378

Wang, Jun; Sun, Jingwei; Liu, Linda N; Flies, Dallas B; Nie, Xinxin; Toki, Maria; Zhang, Jianping; Song, Chang; Zarr, Melissa; Zhou, Xu; Han, Xue; Archer, Kristina A; O'Neill, Thomas; Herbst, Roy S; Boto, Agedi N; Sanmamed, Miguel F; Langermann, Solomon; Rimm, David L; Chen, Lieping

Nature medicine. 2019 04; 25(4):656-666

Wang, Jun; Sanmamed, Miguel F; Datar, Ila; Su, Tina Tianjiao; Ji, Lan; Sun, Jingwei; Chen, Ling; Chen, Yusheng; Zhu, Gefeng; Yin, Weiwei; Zheng, Linghua; Zhou, Ting; Badri, Ti; Yao, Sheng; Zhu, Shu; Boto, Agedi; Sznol, Mario; Melero, Ignacio; Vignali, Dario A A; Schalper, Kurt; Chen, Lieping

Cell. 2019 01 10; 176(1-2):334-347.e12