Jun Wang

Jun Wang, PhD

Assistant Professor, Department of Pathology

Summary

Dr. Jun Wang is currently an assistant professor at Department of Pathology and the Laura and Isaac Perlmutter Cancer Center of NYU Langone health who has been working on cancer immunology and immunotherapy for over fifteen years. He finished his postdoctoral research in Dr. Lieping Chen’s laboratory at Johns Hopkins Medicine and the Yale Department of Immunobiology. His research interest lies in discovering and understanding novel receptor-ligand pathways with immune-modulatory functions and how to best utilize them as potential targets for cancer immunotherapy. During these years, Dr. Wang developed several genome-scale proprietary screening platforms leading to valuable industrial partnerships, some of which formed the basis of NextCure, Inc. He has discovered several first-in-class targets, such as FGL1/LAG-3 and Siglec-15, which represent novel tumor immune evasion mechanisms and new approaches for cancer immunotherapy. The first-in-human cancer clinical trials targeting the Siglec-15 pathway are currently ongoing at Yale and NYU, in addition to other sites. Moreover, Dr. Wang also examined the mechanisms of anti-tumor efficacy versus liver toxicity of agonistic anti-CD137 (4-1BB) therapy and provided new insights for alleviating liver pathology without disruption of anti-tumor immunity.Moving forward, Dr. Wang is planning to use innovative technologies to identify key mechanisms within the tumor microenvironment in the control of anti-tumor immunity and to design useful next-generation cancer immunotherapies with rational biomarkers.

Phone

212-263-1506

Academic office

550 First Ave, Smilow Research Building

316

New York, NY 10016

Lab Website
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PhD from Chinese Academy of Sciences

Yale University, Cancer Immunology and Immunotherapy

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Scientific reports. 2024 Dec 01; 14(<prism:issueIdentifier>1):?-?

Moravec, Ziva; Zhao, Yue; Voogd, Rhianne; Cook, Danielle R; Kinrot, Seon; Capra, Benjamin; Yang, Haiyan; Raud, Brenda; Ou, Jiayu; Xuan, Jiekun; Wei, Teng; Ren, Lili; Hu, Dandan; Wang, Jun; Haanen, John B A G; Schumacher, Ton N; Chen, Xi; Porter, Ely; Scheper, Wouter

Nature biotechnology. 2024 Apr 23;

Silberstein, John L; Du, Jasper; Chan, Kun-Wei; Frank, Jessica A; Mathews, Irimpan I; Kim, Yong Bin; You, Jia; Lu, Qiao; Liu, Jia; Philips, Elliot A; Liu, Phillip; Rao, Eric; Fernandez, Daniel; Rodriguez, Grayson E; Kong, Xiang-Peng; Wang, Jun; Cochran, Jennifer R

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2024 Mar 19; 121(12):e2310866121

Philips, Elliot A; Liu, Jia; Kvalvaag, Audun; Mørch, Alexander M; Tocheva, Anna S; Ng, Charles; Liang, Hong; Ahearn, Ian M; Pan, Ruimin; Luo, Christina C; Leithner, Alexander; Qin, Zhihua; Zhou, Yong; Garcia-España, Antonio; Mor, Adam; Littman, Dan R; Dustin, Michael L; Wang, Jun; Kong, Xiang-Peng

Science immunology. 2024 Mar 08; 9(93):eade6256

Wang, Jun; Lu, Qiao; Chen, Xufeng; Aifantis, Iannis

Trends in immunology. 2024 Mar; 45(3):177-187

Kim, Tae Kon; Han, Xue; Hu, Qianni; Vandsemb, Esten N; Fielder, Carly M; Hong, Junshik; Kim, Kwang Woon; Mason, Emily F; Plowman, R Skipper; Wang, Jun; Wang, Qi; Zhang, Jian-Ping; Badri, Ti; Sanmamed, Miguel F; Zheng, Linghua; Zhang, Tianxiang; Alawa, Jude; Lee, Sang Won; Zeidan, Amer M; Halene, Stephanie; Pillai, Manoj M; Chandhok, Namrata S; Lu, Jun; Xu, Mina L; Gore, Steven D; Chen, Lieping

Journal of clinical investigation. 2024 Feb 01; 134(3):

Chen, Xufeng; Lu, Qiao; Zhou, Hua; Liu, Jia; Nadorp, Bettina; Lasry, Audrey; Sun, Zhengxi; Lai, Baoling; Rona, Gergely; Zhang, Jiangyan; Cammer, Michael; Wang, Kun; Al-Santli, Wafa; Ciantra, Zoe; Guo, Qianjin; You, Jia; Sengupta, Debrup; Boukhris, Ahmad; Zhang, Hongbing; Liu, Cheng; Cresswell, Peter; Dahia, Patricia L M; Pagano, Michele; Aifantis, Iannis; Wang, Jun

Cell. 2023 Aug 31; 186(18):3903-3920.e21

Melero, Ignacio; Sanmamed, Miguel F; Glez-Vaz, Javier; Luri-Rey, Carlos; Wang, Jun; Chen, Lieping

Cancer discovery. 2023 Mar 01; 13(3):552-569