Karim-Jean Armache

Karim-Jean Armache, PhD

Laura and Isaac Perlmutter Professor of Biochemistry, Department of Biochemistry and Molecular Pharmacology

Keywords
epigenetics, gene regulation, transcription, chromatin, cancer, development
Summary

Our laboratory investigates the roles of chromatin-modifying complexes, including the Polycomb Group (PcG), the Trithorax Group (TrxG), and DNA methylation machinery, in regulating gene activation and silencing. We focus on the mechanisms by which these complexes maintain the balance of gene expression and ensure the inheritance of chromatin state during replication. Additionally, we are committed to understanding how disruptions in these regulatory pathways lead to abnormal development and cancer.

Phone

212-263-0585

Academic office

450 East 29th St , ACLS East Tower

9, 931

New York, NY 10016

Lab Website
Armache Lab
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Positions

Laura and Isaac Perlmutter Professor of Biochemistry, Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine

Graduate Education

PhD from Ludwig Maximilian University Munich

Loss of DOT1L disrupts neuronal transcription and leads to a neurodevelopmental disorder

Maroni, Marissa J; Barton, Melissa; Lynch, Katherine; Deshwar, Ashish R; Campbell, Philip D; Millard, Josephine; Lee, Rachel; Cohen, Annastelle; Ahmad, Rili; Paranjapye, Alekh; Faundes, Víctor; Repetto, Gabriela M; McKenna, Caoimhe; Shillington, Amelle L; Phornphutkul, Chanika; Hove, Hanne B; Mancini, Grazia M S; Schot, Rachel; Barakat, Tahsin Stefan; Richmond, Christopher M; Lauzon, Julie; Ibrahim, Ahmed Ibrahim Elsayed; Nava, Caroline; Héron, Delphine; van Aalst, Minke M A; Atemin, Slavena; Sleptsova, Mila; Aleksandrova, Iliyana; Todorova, Albena; Watkins, Debra L; Kozenko, Mariya A; Natera-de Benito, Daniel; Ortez, Carlos; Estevez-Arias, Berta; Lecoquierre, François; Cassinari, Kévin; Guerrot, Anne-Marie; Levy, Jonathan; Latypova, Xenia; Verloes, Alain; Innes, A Micheil; Yang, Xiao-Ru; Banka, Siddharth; Vill, Katharina; Jacob, Maureen; Kruer, Michael; Skidmore, Peter; Galaz-Montoya, Carolina I; Bakhtiari, Somayeh; Mester, Jessica L; Granato, Michael; Armache, Karim-Jean; Costain, Gregory; Korb, Erica

Brain. 2025 Jun 11;

Circular Engineered Sortase for Interrogating Histone H3 in Chromatin

Whedon, Samuel D; Lee, Kwangwoon; Wang, Zhipeng A; Zahn, Emily; Lu, Congcong; Yapa Abeywardana, Maheeshi; Fairall, Louise; Nam, Eunju; DuBois-Coyne, Sarah; De Ioannes, Pablo; Sheng, Xinlei; Andrei, Adelina; Lundberg, Emily; Jiang, Jennifer; Armache, Karim-Jean; Zhao, Yingming; Schwabe, John W R; Wu, Mingxuan; Garcia, Benjamin A; Cole, Philip A

Journal of the American Chemical Society. 2024 Dec 11; 146(49):33914-33927

Read-write mechanisms of H2A ubiquitination by Polycomb repressive complex 1

López, Victoria Godínez; Valencia-Sánchez, Marco Igor; Abini-Agbomson, Stephen; Thomas, Jonathan F; Lee, Rachel; De Ioannes, Pablo; Sosa, Brian A; Armache, Jean-Paul; Armache, Karim-Jean

Nature. 2024 Dec; 636(8043):755-761

Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch

Gretarsson, Kristjan H; Abini-Agbomson, Stephen; Gloor, Susan L; Weinberg, Daniel N; McCuiston, Jamie L; Kumary, Vishnu Udayakumar Sunitha; Hickman, Allison R; Sahu, Varun; Lee, Rachel; Xu, Xinjing; Lipieta, Natalie; Flashner, Samuel; Adeleke, Oluwatobi A; Popova, Irina K; Taylor, Hailey F; Noll, Kelsey; Windham, Carolina Lin; Maryanski, Danielle N; Venters, Bryan J; Nakagawa, Hiroshi; Keogh, Michael-Christopher; Armache, Karim-Jean; Lu, Chao

Science advances. 2024 Aug 30; 10(35):eadp0975

Systematic Fe(II)-EDTA Method of Dose-Dependent Hydroxyl Radical Generation for Protein Oxidative Footprinting

Chapman, Jessica R; Paukner, Max; Leser, Micheal; Teng, Kai Wen; Koide, Shohei; Holder, Marlene; Armache, Karim-Jean; Becker, Chris; Ueberheide, Beatrix; Brenowitz, Michael

Analytical chemistry. 2023 Dec 19; 95(50):18316-18325

Giant variations in giant virus genome packaging

Talbert, Paul B; Henikoff, Steven; Armache, Karim-Jean

Trends in biochemical sciences. 2023 Dec; 48(12):1071-1082

Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1

Abini-Agbomson, Stephen; Gretarsson, Kristjan; Shih, Rochelle M; Hsieh, Laura; Lou, Tracy; De Ioannes, Pablo; Vasilyev, Nikita; Lee, Rachel; Wang, Miao; Simon, Matthew D; Armache, Jean-Paul; Nudler, Evgeny; Narlikar, Geeta; Liu, Shixin; Lu, Chao; Armache, Karim-Jean

Molecular cell. 2023 Aug 17; 83(16):2872-2883.e7

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1

Thomas, Jonathan F; Valencia-Sánchez, Marco Igor; Tamburri, Simone; Gloor, Susan L; Rustichelli, Samantha; Godínez-López, Victoria; De Ioannes, Pablo; Lee, Rachel; Abini-Agbomson, Stephen; Gretarsson, Kristjan; Burg, Jonathan M; Hickman, Allison R; Sun, Lu; Gopinath, Saarang; Taylor, Hailey F; Sun, Zu-Wen; Ezell, Ryan J; Vaidya, Anup; Meiners, Matthew J; Cheek, Marcus A; Rice, William J; Svetlov, Vladimir; Nudler, Evgeny; Lu, Chao; Keogh, Michael-Christopher; Pasini, Diego; Armache, Karim-Jean

Science advances. 2023 Aug 09; 9(32):eadg9832

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