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Karim-Jean Armache, PhD

Skirball Institute

Assistant Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
biophysics, cancer, developmental genetics, genome integrity, metabolism, stem cell biology

Phone

212-263-0585

Academic office

540 First Avenue, Skirball Institute

3, 17

New York, NY 10016

Lab Website
Armache Lab
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Positions

Assistant Professor, Department of Biochemistry and Molecular Pharmacology

Graduate Education

PhD from Ludwig Maximillians University Munich

Structure and function of the Orc1 BAH-nucleosome complex

De Ioannes, Pablo; Leon, Victor A; Kuang, Zheng; Wang, Miao; Boeke, Jef D; Hochwagen, Andreas; Armache, Karim-Jean

Nature communications. 2019 Jul 01; 10(1):2894

Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination

Valencia-Sánchez, Marco Igor; De Ioannes, Pablo; Wang, Miao; Vasilyev, Nikita; Chen, Ruoyu; Nudler, Evgeny; Armache, Jean-Paul; Armache, Karim-Jean

Molecular cell. 2019 Jun 06; 74(5):1010-1019.e6

Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2

Lee, Chul-Hwan; Holder, Marlene; Grau, Daniel; Saldaña-Meyer, Ricardo; Yu, Jia-Ray; Ganai, Rais Ahmad; Zhang, Jenny; Wang, Miao; LeRoy, Gary; Dobenecker, Marc-Werner; Reinberg, Danny; Armache, Karim-Jean

Molecular cell. 2018 05 03; 70(3):435-448.e5

A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response

Alpatov, Roman; Lesch, Bluma J; Nakamoto-Kinoshita, Mika; Blanco, Andres; Chen, Shuzhen; Stutzer, Alexandra; Armache, Karim J; Simon, Matthew D; Xu, Chao; Ali, Muzaffar; Murn, Jernej; Prisic, Sladjana; Kutateladze, Tatiana G; Vakoc, Christopher R; Min, Jinrong; Kingston, Robert E; Fischle, Wolfgang; Warren, Stephen T; Page, David C; Shi, Yang

Cell. 2014 May 08; 157(4):869-81

Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 A resolution

Armache, Karim-Jean; Garlick, Joseph D; Canzio, Daniele; Narlikar, Geeta J; Kingston, Robert E

Science. 2011 Nov 18; 334(6058):977-82

RNA polymerase II-TFIIB structure and mechanism of transcription initiation

Kostrewa, Dirk; Zeller, Mirijam E; Armache, Karim-Jean; Seizl, Martin; Leike, Kristin; Thomm, Michael; Cramer, Patrick

Nature. 2009 Nov 19; 462(7271):323-30

Structure-function studies of the RNA polymerase II elongation complex

Brueckner, Florian; Armache, Karim Jean; Cheung, Alan; Damsma, Gerke E; Kettenberger, Hubert; Lehmann, Elisabeth; Sydow, Jasmin; Cramer, Patrick

Acta crystallographica. Section D, Biological crystallography. 2009 Feb; 65(Pt 2):112-20

Structure of eukaryotic RNA polymerases

Cramer, P; Armache, K-J; Baumli, S; Benkert, S; Brueckner, F; Buchen, C; Damsma, G E; Dengl, S; Geiger, S R; Jasiak, A J; Jawhari, A; Jennebach, S; Kamenski, T; Kettenberger, H; Kuhn, C-D; Lehmann, E; Leike, K; Sydow, J F; Vannini, A

Annual review of biophysics. 2008 Jul; 37:337-52

See All Publications (14)