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Ken H. Cadwell

Ken H. Cadwell, PhD

Research Professor, Department of Microbiology

Keywords
cancer, immunology, metabolism, microbiology, microbiome, understanding how infectious agents and the microbiome regulate susceptibility to inflammatory disease
Summary

The Cadwell Lab investigates how the immune system is controlled during infectious and inflammatory diseases. The immune system is tasked with defending against life-threatening infectious agents, but at the same time must avoid unnecessary reactions against beneficial microbes that are part of the microbiome. Such unwanted immune responses are implicated in a variety of chronic diseases including inflammatory bowel disease and cancer. A key research goal is to uncover the cell biological processes that control the immune response when confronted with the diverse infectious agents found in the environment. Ongoing projects include: (1) Identifying gene-microbe interactions that contribute to inflammatory bowel disease, (2) elucidating the role of the cellular process of autophagy in host-pathogen interactions, and (3) examining the viral component of the microbiome, also known as the virome.

Phone

212-263-8891

Academic office

Alexandria Ctr, West Tower, 430 East 29th Street

Room 409

New York, NY 10016

Lab Website
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PhD from University of California at Berkeley

Fellowship, Washington Univesity School of Medicine, Pathology and Immunology

Dallari, Simone; Martinez Pazos, Vicky; Munoz Eusse, Juan; Wellens, Judith; Thompson, Craig; Colombel, Jean-Frederic; Satsangi, Jack; Cadwell, Ken; Wong, Serre-Yu; ,

Scientific reports. 2024 Jan 02; 14(1):186

Downie, Alexander E; Oyesola, Oyebola; Barre, Ramya S; Caudron, Quentin; Chen, Ying-Han; Dennis, Emily J; Garnier, Romain; Kiwanuka, Kasalina; Menezes, Arthur; Navarrete, Daniel J; Mondragón-Palomino, Octavio; Saunders, Jesse B; Tokita, Christopher K; Zaldana, Kimberly; Cadwell, Ken; Loke, P'ng; Graham, Andrea L

Science advances. 2023 Dec 22; 9(51):eadh8310

Muharram, Ghaffar; Thépaut, Marion; Lobert, Pierre-Emmanuel; Grandjean, Teddy; Boulard, Olivier; Delacre, Myriam; Wakeford, Emmrich; Wheeler, Richard; Poulin, Lionel Franz; Boneca, Ivo Gomperts; Lafont, Frank; Michallet, Marie-Cécile; Hober, Didier; Cadwell, Ken; Chamaillard, Mathias

Gut microbes. 2023 Dec; 15(2):2249960

Yang, Katharine Lu; Mullins, Briana J; Lejeune, Alannah; Ivanova, Ellie; Shin, Jong; Bajwa, Sofia; Possemato, Richard; Cadwell, Ken; Scher, Jose U; Koralov, Sergei B

Arthritis & rheumatology. 2023 Nov 22;

Bernard-Raichon, Lucie; Cadwell, Ken

Annual review of virology. 2023 Sep 29; 10(1):477-502

Jang, Kyung Ku; Heaney, Thomas; London, Mariya; Ding, Yi; Putzel, Gregory; Yeung, Frank; Ercelen, Defne; Chen, Ying-Han; Axelrad, Jordan; Gurunathan, Sakteesh; Zhou, Chaoting; Podkowik, Magdalena; Arguelles, Natalia; Srivastava, Anusha; Shopsin, Bo; Torres, Victor J; Keestra-Gounder, A Marijke; Pironti, Alejandro; Griffin, Matthew E; Hang, Howard C; Cadwell, Ken

Cell host & microbe. 2023 Sep 13; 31(9):1450-1468.e8

Robertson, Amicha; Sall, Joseph; Venzon, Mericien; Olivas, Janet J; Zheng, Xuhui; Cammer, Michael; Antao, Noelle; Zhou, Chunyi; Devlin, Joseph C; Saes Thur, Rafaela; Bethony, Jeffrey; Nejsum, Peter; Shopsin, Bo; Torres, Victor J; Liang, Feng-Xia; Cadwell, Ken

PLoS pathogens. 2023 Sep; 19(9):e1011647

Chen, Ying-Han; Yeung, Frank; Lacey, Keenan A; Zaldana, Kimberly; Lin, Jian-Da; Bee, Gavyn Chern Wei; McCauley, Caroline; Barre, Ramya S; Liang, Shen-Huan; Hansen, Christina B; Downie, Alexander E; Tio, Kyle; Weiser, Jeffrey N; Torres, Victor J; Bennett, Richard J; Loke, P'ng; Graham, Andrea L; Cadwell, Ken

Science immunology. 2023 Jun 23; 8(84):eadd6910