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Ken H. Cadwell

Ken H. Cadwell, PhD

Recanati Family Professor of Microbiology, Department of Microbiology

Professor, Department of Medicine

Keywords
cancer, immunology, metabolism, microbiology, microbiome, understanding how infectious agents and the microbiome regulate susceptibility to inflammatory disease
Summary

The Cadwell Lab investigates how the immune system is controlled during infectious and inflammatory diseases. The immune system is tasked with defending against life-threatening infectious agents, but at the same time must avoid unnecessary reactions against beneficial microbes that are part of the microbiome. Such unwanted immune responses are implicated in a variety of chronic diseases including inflammatory bowel disease and cancer. A key research goal is to uncover the cell biological processes that control the immune response when confronted with the diverse infectious agents found in the environment. Ongoing projects include: (1) Identifying gene-microbe interactions that contribute to inflammatory bowel disease, (2) elucidating the role of the cellular process of autophagy in host-pathogen interactions, and (3) examining the viral component of the microbiome, also known as the virome.

Phone

212-263-8891

Academic office

Alexandria Ctr, West Tower, 430 East 29th Street

Room 409

New York, NY 10016

Lab Website
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PhD from University of California at Berkeley

Fellowship, Washington Univesity School of Medicine, Pathology and Immunology

Bernard-Raichon, Lucie; Venzon, Mericien; Klein, Jon; Axelrad, Jordan E; Zhang, Chenzhen; Sullivan, Alexis P; Hussey, Grant A; Casanovas-Massana, Arnau; Noval, Maria G; Valero-Jimenez, Ana M; Gago, Juan; Putzel, Gregory; Pironti, Alejandro; Wilder, Evan; Thorpe, Lorna E; Littman, Dan R; Dittmann, Meike; Stapleford, Kenneth A; Shopsin, Bo; Torres, Victor J; Ko, Albert I; Iwasaki, Akiko; Cadwell, Ken; Schluter, Jonas

Nature communications. 2022 Nov 01; 13(1):5926

Matsuzawa-Ishimoto, Yu; Yao, Xiaomin; Koide, Akiko; Ueberheide, Beatrix M; Axelrad, Jordan E; Reis, Bernardo S; Parsa, Roham; Neil, Jessica A; Devlin, Joseph C; Rudensky, Eugene; Dewan, M Zahidunnabi; Cammer, Michael; Blumberg, Richard S; Ding, Yi; Ruggles, Kelly V; Mucida, Daniel; Koide, Shohei; Cadwell, Ken

Nature. 2022 10; 610(7932):547-554

Ching, Krystal L; de Vries, Maren; Gago, Juan; Dancel-Manning, Kristen; Sall, Joseph; Rice, William J; Barnett, Clea; Khodadadi-Jamayran, Alireza; Tsirigos, Aristotelis; Liang, Feng-Xia; Thorpe, Lorna E; Shopsin, Bo; Segal, Leopoldo N; Dittmann, Meike; Torres, Victor J; Cadwell, Ken

PLoS biology. 2022 Sep; 20(9):e3001754

Lacey, Keenan A; Gonzalez, Sandra; Yeung, Frank; Putzel, Gregory; Podkowik, Magdalena; Pironti, Alejandro; Shopsin, Bo; Cadwell, Ken; Torres, Victor J

MBio. 2022 06 28; 13(3):e0124022

Venzon, Mericien; Das, Ritika; Luciano, Daniel J; Burnett, Julia; Park, Hyun Shin; Devlin, Joseph Cooper; Kool, Eric T; Belasco, Joel G; Hubbard, E Jane Albert; Cadwell, Ken

Cell host & microbe. 2022 Jun 08; 30(6):786-797.e8

Gago, Juan; Filardo, Thomas D; Conderino, Sarah; Magaziner, Samuel J; Dubrovskaya, Yanina; Inglima, Kenneth; Iturrate, Eduardo; Pironti, Alejandro; Schluter, Jonas; Cadwell, Ken; Hochman, Sarah; Li, Huilin; Torres, Victor J; Thorpe, Lorna E; Shopsin, Bo

Open forum infectious diseases. 2022 Jun; 9(6):ofac083

Jang, Kyung Ku; Kaczmarek, Maria E; Dallari, Simone; Chen, Ying-Han; Tada, Takuya; Axelrad, Jordan; Landau, Nathaniel R; Stapleford, Kenneth A; Cadwell, Ken

PLoS biology. 2022 Mar; 20(3):e3001592