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Ken H. Cadwell

Ken H. Cadwell, PhD

Recanati Family Professor of Microbiology, Department of Microbiology

Professor, Department of Medicine

Keywords
cancer, immunology, metabolism, microbiology, microbiome, understanding how infectious agents and the microbiome regulate susceptibility to inflammatory disease
Summary

The Cadwell Lab investigates how the immune system is controlled during infectious and inflammatory diseases. The immune system is tasked with defending against life-threatening infectious agents, but at the same time must avoid unnecessary reactions against beneficial microbes that are part of the microbiome. Such unwanted immune responses are implicated in a variety of chronic diseases including inflammatory bowel disease and cancer. A key research goal is to uncover the cell biological processes that control the immune response when confronted with the diverse infectious agents found in the environment. Ongoing projects include: (1) Identifying gene-microbe interactions that contribute to inflammatory bowel disease, (2) elucidating the role of the cellular process of autophagy in host-pathogen interactions, and (3) examining the viral component of the microbiome, also known as the virome.

Phone

212-263-8891

Academic office

Alexandria Ctr, West Tower, 430 East 29th Street

Room 409

New York, NY 10016

Lab Website
Cadwell Lab
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Positions

Recanati Family Professor of Microbiology, Department of Microbiology at NYU Grossman School of Medicine

Professor, Department of Medicine at NYU Grossman School of Medicine

Graduate Education

PhD from University of California at Berkeley

Residency And Fellowship Training

Fellowship, Washington Univesity School of Medicine, Pathology and Immunology

Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infection

Jang, Kyung Ku; Kaczmarek, Maria E; Dallari, Simone; Chen, Ying-Han; Tada, Takuya; Axelrad, Jordan; Landau, Nathaniel R; Stapleford, Kenneth A; Cadwell, Ken

PLoS biology. 2022 Mar; 20(3):e3001592

IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment

Lin, Xun; Gaudino, Stephen J; Jang, Kyung Ku; Bahadur, Tej; Singh, Ankita; Banerjee, Anirban; Beaupre, Michael; Chu, Timothy; Wong, Hoi Tong; Kim, Chang-Kyung; Kempen, Cody; Axelrad, Jordan; Huang, Huakang; Khalid, Saba; Shah, Vyom; Eskiocak, Onur; Parks, Olivia B; Berisha, Artan; McAleer, Jeremy P; Good, Misty; Hoshino, Miko; Blumberg, Richard; Bialkowska, Agnieszka B; Gaffen, Sarah L; Kolls, Jay K; Yang, Vincent W; Beyaz, Semir; Cadwell, Ken; Kumar, Pawan

Immunity. 2022 Feb 08; 55(2):237-253.e8

Playing dirty with virus transmission

Herrmann, Christin; Cadwell, Ken

Journal of experimental medicine. 2022 02 07; 219(2):

Atovaquone and Berberine Chloride Reduce SARS-CoV-2 Replication In Vitro

Rodriguez-Rodriguez, Bruno A; Noval, Maria G; Kaczmarek, Maria E; Jang, Kyung Ku; Thannickal, Sara A; Cifuentes Kottkamp, Angelica; Brown, Rebecca S; Kielian, Margaret; Cadwell, Ken; Stapleford, Kenneth A

Viruses. 2021 12 04; 13(12):

Autophagy in major human diseases

Klionsky, Daniel J; Petroni, Giulia; Amaravadi, Ravi K; Baehrecke, Eric H; Ballabio, Andrea; Boya, Patricia; Bravo-San Pedro, José Manuel; Cadwell, Ken; Cecconi, Francesco; Choi, Augustine M K; Choi, Mary E; Chu, Charleen T; Codogno, Patrice; Colombo, Maria Isabel; Cuervo, Ana Maria; Deretic, Vojo; Dikic, Ivan; Elazar, Zvulun; Eskelinen, Eeva-Liisa; Fimia, Gian Maria; Gewirtz, David A; Green, Douglas R; Hansen, Malene; Jäättelä, Marja; Johansen, Terje; Juhász, Gábor; Karantza, Vassiliki; Kraft, Claudine; Kroemer, Guido; Ktistakis, Nicholas T; Kumar, Sharad; Lopez-Otin, Carlos; Macleod, Kay F; Madeo, Frank; Martinez, Jennifer; Meléndez, Alicia; Mizushima, Noboru; Münz, Christian; Penninger, Josef M; Perera, Rushika M; Piacentini, Mauro; Reggiori, Fulvio; Rubinsztein, David C; Ryan, Kevin M; Sadoshima, Junichi; Santambrogio, Laura; Scorrano, Luca; Simon, Hans-Uwe; Simon, Anna Katharina; Simonsen, Anne; Stolz, Alexandra; Tavernarakis, Nektarios; Tooze, Sharon A; Yoshimori, Tamotsu; Yuan, Junying; Yue, Zhenyu; Zhong, Qing; Galluzzi, Lorenzo; Pietrocola, Federico

EMBO journal. 2021 Oct 01; 40(19):e108863

Serologic Response to Messenger RNA Coronavirus Disease 2019 Vaccines in Inflammatory Bowel Disease Patients Receiving Biologic Therapies

Wong, Serre-Yu; Dixon, Rebekah; Martinez Pazos, Vicky; Gnjatic, Sacha; Colombel, Jean-Frederic; Cadwell, Ken

Gastroenterology. 2021 08; 161(2):715-718.e4

Gut microbiome dysbiosis during COVID-19 is associated with increased risk for bacteremia and microbial translocation

Venzon, Mericien; Bernard-Raichon, Lucie; Klein, Jon; Axelrad, Jordan; Hussey, Grant; Sullivan, Alexis; Casanovas-Massana, Arnau; Noval, Maria; Valero-Jimenez, Ana; Gago, Juan; Wilder, Evan; Team, Yale Impact Research; Iwasaki, Akiko; Thorpe, Lorna; Littman, Dan; Dittmann, Meike; Stapleford, Kenneth; Shopsin, Bo; Torres, Victor; Ko, Albert; Cadwell, Ken; Schluter, Jonas

Research square. 2021 Jul 27;

Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome

Dallari, Simone; Heaney, Thomas; Rosas-Villegas, Adriana; Neil, Jessica A; Wong, Serre-Yu; Brown, Judy J; Urbanek, Kelly; Herrmann, Christin; Depledge, Daniel P; Dermody, Terence S; Cadwell, Ken

Cell host & microbe. 2021 Jun 09; 29(6):1014-1029.e8

See All Publications (92)

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