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Ken H. Cadwell

Ken H. Cadwell, PhD

Skirball Institute

Associate Professor, Department of Microbiology

Associate Professor, Department of Medicine

Keywords
cancer, immunology, metabolism, microbiology, microbiome, understanding how infectious agents and the microbiome regulate susceptibility to inflammatory disease
Summary

The Cadwell Lab investigates how the immune system is controlled during infectious and inflammatory diseases. The immune system is tasked with defending against life-threatening infectious agents, but at the same time must avoid unnecessary reactions against beneficial microbes that are part of the microbiome. Such unwanted immune responses are implicated in a variety of chronic diseases including inflammatory bowel disease and cancer. A key research goal is to uncover the cell biological processes that control the immune response when confronted with the diverse infectious agents found in the environment. Ongoing projects include: (1) Identifying gene-microbe interactions that contribute to inflammatory bowel disease, (2) elucidating the role of the cellular process of autophagy in host-pathogen interactions, and (3) examining the viral component of the microbiome, also known as the virome.

Phone

212-263-8891

Academic office

Alexandria Ctr, West Tower, 430 East 29th Street

Room 409

New York, NY 10016

Lab Website
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PhD from University of California at Berkeley

Fellowship, Washington Univesity School of Medicine, Pathology and Immunology

Yu, Shiyan; Balasubramanian, Iyshwarya; Laubitz, Daniel; Tong, Kevin; Bandyopadhyay, Sheila; Lin, Xiang; Flores, Juan; Singh, Rajbir; Liu, Yue; Macazana, Carlos; Zhao, Yanlin; Béguet-Crespel, Fabienne; Patil, Karuna; Midura-Kiela, Monica T; Wang, Daniel; Yap, George S; Ferraris, Ronaldo P; Wei, Zhi; Bonder, Edward M; Häggblom, Max M; Zhang, Lanjing; Douard, Veronique; Verzi, Michael P; Cadwell, Ken; Kiela, Pawel R; Gao, Nan

Immunity. 2020 Aug 18; 53(2):398-416.e8

Ozkul, Ceren; Ruiz, Victoria E; Battaglia, Thomas; Xu, Joseph; Roubaud-Baudron, Claire; Cadwell, Ken; Perez-Perez, Guillermo I; Blaser, Martin J

Genome medicine. 2020 07 25; 12(1):65

Matsuzawa-Ishimoto, Yu; Hine, Ashley; Shono, Yusuke; Rudensky, Eugene; Lazrak, Amina; Yeung, Frank; Neil, Jessica A; Yao, Xiaomin; Chen, Ying-Han; Heaney, Thomas; Schuster, Samantha L; Zwack, Erin E; Axelrad, Jordan Eric; Hudesman, David; Tsai, Jennifer Jia-Ying; Nichols, Katherine B; Dewan, M Zahidunnabi; Cammer, Michael; Beal, Allison; Hoffman, Sandra; Geddes, Brad; Bertin, John; Liu, Chen; Torres, Victor J; Loke, P'ng; van den Brink, Marcel Rm; Cadwell, Ken

Blood. 2020 Jun 25; 135(26):2388-2401

Lin, Jian-Da; Devlin, Joseph C; Yeung, Frank; McCauley, Caroline; Leung, Jacqueline M; Chen, Ying-Han; Cronkite, Alex; Hansen, Christina; Drake-Dunn, Charlotte; Ruggles, Kelly V; Cadwell, Ken; Graham, Andrea L; Loke, P'ng

Cell host & microbe. 2020 May 13; 27(5):830-840.e4

Yeung, Frank; Chen, Ying-Han; Lin, Jian-Da; Leung, Jacqueline M; McCauley, Caroline; Devlin, Joseph C; Hansen, Christina; Cronkite, Alex; Stephens, Zac; Drake-Dunn, Charlotte; Fulmer, Yi; Shopsin, Bo; Ruggles, Kelly V; Round, June L; Loke, P'ng; Graham, Andrea L; Cadwell, Ken

Cell host & microbe. 2020 May 13; 27(5):809-822.e6

Xie, Yadong; Zhao, Yifan; Shi, Lei; Li, Wei; Chen, Kun; Li, Min; Chen, Xia; Zhang, Haiwei; Li, Tiantian; Matsuzawa-Ishimoto, Yu; Yao, Xiaomin; Shao, Dianhui; Ke, Zunfu; Li, Jian; Chen, Yan; Zhang, Xiaoming; Cui, Jun; Cui, Shuzhong; Leng, Qibin; Cadwell, Ken; Li, Xiaoxia; Wei, Hong; Zhang, Haibing; Li, Huabin; Xiao, Hui

Journal of clinical investigation. 2020 Apr 01; 130(4):2111-2128

Keller, Matthew D; Torres, Victor J; Cadwell, Ken

Cell death & differentiation. 2020 Mar; 27(3):872-886

Keller, Matthew D; Ching, Krystal L; Liang, Feng-Xia; Dhabaria, Avantika; Tam, Kayan; Ueberheide, Beatrix M; Unutmaz, Derya; Torres, Victor J; Cadwell, Ken

Nature. 2020 Mar; 579(7798):260-264