Ken H. Cadwell

Ken H. Cadwell, PhD

Skirball Institute

Associate Professor, Department of Microbiology

Keywords
cancer, immunology, metabolism, microbiology, microbiome, understanding how infectious agents and the microbiome regulate susceptibility to inflammatory disease
Summary

The Cadwell Lab investigates how the immune system is controlled during infectious and inflammatory diseases. The immune system is tasked with defending against life-threatening infectious agents, but at the same time must avoid unnecessary reactions against beneficial microbes that are part of the microbiome. Such unwanted immune responses are implicated in a variety of chronic diseases including inflammatory bowel disease and cancer. A key research goal is to uncover the cell biological processes that control the immune response when confronted with the diverse infectious agents found in the environment. Ongoing projects include: (1) Identifying gene-microbe interactions that contribute to inflammatory bowel disease, (2) elucidating the role of the cellular process of autophagy in host-pathogen interactions, and (3) examining the viral component of the microbiome, also known as the virome.

Phone

212-263-8891

Academic office

Alexandria Ctr, West Tower, 430 East 29th Street

Room 409

New York, NY 10016

Lab Website
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Associate Professor, Department of Microbiology

PhD from University of California at Berkeley

Fellowship, Washington Univesity School of Medicine, Pathology and Immunology

Cadwell, Ken

Journal of experimental medicine. 2018 Jul 02; 215(7):1771-1773

Matsuzawa-Ishimoto, Yu; Hwang, Seungmin; Cadwell, Ken

Annual review of immunology. 2018 Apr 26; 36:73-7101

Wilen, Craig B; Lee, Sanghyun; Hsieh, Leon L; Orchard, Robert C; Desai, Chandni; Hykes, Barry L; McAllaster, Michael R; Balce, Dale R; Feehley, Taylor; Brestoff, Jonathan R; Hickey, Christina A; Yokoyama, Christine C; Wang, Ya-Ting; MacDuff, Donna A; Kreamalmayer, Darren; Howitt, Michael R; Neil, Jessica A; Cadwell, Ken; Allen, Paul M; Handley, Scott A; van Lookeren Campagne, Menno; Baldridge, Megan T; Virgin, Herbert W

Science. 2018 Apr 13; 360(6385):204-208

Cadwell, Ken; Debnath, Jayanta

Journal of cell biology. 2018 Mar 05; 217(3):813-822

Matsuzawa-Ishimoto, Yu; Shono, Yusuke; Gomez, Luis E; Hubbard-Lucey, Vanessa M; Cammer, Michael; Neil, Jessica; Dewan, M Zahidunnabi; Lieberman, Sophia R; Lazrak, Amina; Marinis, Jill M; Beal, Allison; Harris, Philip A; Bertin, John; Liu, Chen; Ding, Yi; van den Brink, Marcel R M; Cadwell, Ken

Journal of experimental medicine. 2017 Oct 31; 214(12):3687-3705

Ruiz, Victoria E; Battaglia, Thomas; Kurtz, Zachary D; Bijnens, Luc; Ou, Amy; Engstrand, Isak; Zheng, Xuhui; Iizumi, Tadasu; Mullins, Briana J; Muller, Christian L; Cadwell, Ken; Bonneau, Richard; Perez-Perez, Guillermo I; Blaser, Martin J

Nature communications. 2017 Sep 11; 8(1):518-518

Effect of single early-in-life antibiotic course on microbial community structure and susceptibility to DSS-induced colitis [Meeting Abstract]

Ozkul, C; Ruiz, V; Battaglia, T; Cadwell, K; Blaser, M

Helicobacter. 2017 September; (30th):123

Alissafi, Themis; Banos, Aggelos; Boon, Louis; Sparwasser, Tim; Ghigo, Alessandra; Wing, Kajsa; Vassilopoulos, Dimitrios; Boumpas, Dimitrios; Chavakis, Triantafyllos; Cadwell, Ken; Verginis, Panayotis

Journal of clinical investigation. 2017 Jun 5; 127(7):2789-2804

A Gut Parasite Helps Fight Inflammatory Bowel Disease