The Cadwell Lab investigates how the immune system is controlled during infectious and inflammatory diseases. The immune system is tasked with defending against life-threatening infectious agents, but at the same time must avoid unnecessary reactions against beneficial microbes that are part of the microbiome. Such unwanted immune responses are implicated in a variety of chronic diseases including inflammatory bowel disease and cancer. A key research goal is to uncover the cell biological processes that control the immune response when confronted with the diverse infectious agents found in the environment. Ongoing projects include: (1) Identifying gene-microbe interactions that contribute to inflammatory bowel disease, (2) elucidating the role of the cellular process of autophagy in host-pathogen interactions, and (3) examining the viral component of the microbiome, also known as the virome.
Associate Professor, Department of Microbiology
PhD from University of California at Berkeley
Fellowship, Washington Univesity School of Medicine, Pathology and Immunology
Journal of cell biology. 2017 Dec 13; ?-?
Annual review of immunology. 2017 Nov 16; ?-?
Journal of experimental medicine. 2017 Oct 31; 214(12):3687-3705
Nature communications. 2017 Sep 11; 8(1):518-518
Effect of single early-in-life antibiotic course on microbial community structure and susceptibility to DSS-induced colitis [Meeting Abstract]
Helicobacter. 2017 September; Conference:(30th):123
Journal of clinical investigation. 2017 Jun 5; 127(7):2789-2804
Annals of the rheumatic diseases. 2017 MAR; 76:A36-A36
Obesity research & clinical practice. 2017; (),(2017):