Liam J. Holt

Liam J. Holt, PhD

Institute for Systems Genetics

Associate Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
Synthetic Biology, Systems Biology, Cancer, Neurodegeneration, Cell Biology, Mechanobiology, Cell Division, Signalling
Summary

We study fundamental biology, including information processing, mechanobiology, stem cells, and evolution; apply our knowledge to diseases like cancer and neurodegeneration; and use synthetic biology to test our understanding and discoveries about human life. 

For more information, please visit the Holt Lab website.

Phone

646-501-4597

Academic office

435 East 30th Street

9th Floor, Room 906

New York, NY 10016

Lab Website
Holt Lab
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Positions

Associate Professor, Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine

Graduate Education

PhD from University of California, San Francisco

Residency And Fellowship Training

Fellowship, University of California Berkeley, Holt lab

mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding

Delarue, M; Brittingham, G P; Pfeffer, S; Surovtsev, I V; Pinglay, S; Kennedy, K J; Schaffer, M; Gutierrez, J I; Sang, D; Poterewicz, G; Chung, J K; Plitzko, J M; Groves, J T; Jacobs-Wagner, C; Engel, B D; Holt, L J

Cell. 2018 Jul 12; 174(2):338-349.e20

Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

Neurohr, Gabriel E; Terry, Rachel L; Lengefeld, Jette; Bonney, Megan; Brittingham, Gregory P; Moretto, Fabien; Miettinen, Teemu P; Vaites, Laura Pontano; Soares, Luis M; Paulo, Joao A; Harper, J Wade; Buratowski, Stephen; Manalis, Scott; van Werven, Folkert J; Holt, Liam J; Amon, Angelika

Cell. 2019 Feb 21; 176(5):1083-1097.e18

Chromosome clustering by Ki-67 excludes cytoplasm during nuclear assembly

Cuylen-Haering, Sara; Petrovic, Mina; Hernandez-Armendariz, Alberto; Schneider, Maximilian W G; Samwer, Matthias; Blaukopf, Claudia; Holt, Liam J; Gerlich, Daniel W

Nature. 2020 Nov; 587(7833):285-290

The Genome Project-Write

Boeke, Jef D; Church, George; Hessel, Andrew; Kelley, Nancy J; Arkin, Adam; Cai, Yizhi; Carlson, Rob; Chakravarti, Aravinda; Cornish, Virginia W; Holt, Liam; Isaacs, Farren J; Kuiken, Todd; Lajoie, Marc; Lessor, Tracy; Lunshof, Jeantine; Maurano, Matthew T; Mitchell, Leslie A; Rine, Jasper; Rosser, Susan; Sanjana, Neville E; Silver, Pamela A; Valle, David; Wang, Harris; Way, Jeffrey C; Yang, Luhan

Science. 2016 Jul 08; 353(6295):126-7

Microtubules Enhance Mesoscale Effective Diffusivity in the Crowded Metaphase Cytoplasm

Carlini, Lina; Brittingham, Gregory P; Holt, Liam J; Kapoor, Tarun M

Developmental cell. 2020 Sep 14; 54(5):574-582.e4

Ancestral reconstruction reveals mechanisms of ERK regulatory evolution

Sang, Dajun; Pinglay, Sudarshan; Wiewiora, Rafal P; Selvan, Myvizhi E; Lou, Hua Jane; Chodera, John D; Turk, Benjamin E; Gümüş, Zeynep H; Holt, Liam J

eLife. 2019 Aug 13; 8:

Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution

Holt, Liam J; Tuch, Brian B; Villen, Judit; Johnson, Alexander D; Gygi, Steven P; Morgan, David O

Science. 2009 Sep 25; 325(5948):1682-6

Positive feedback sharpens the anaphase switch

Holt, Liam J; Krutchinsky, Andrew N; Morgan, David O

Nature. 2008 Jul 17; 454(7202):353-7

See All Publications (43)

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