Marcin Imielinski

Marcin Imielinski, MD, PhD

Perlmutter Cancer Center

Associate Professor, Department of Pathology

Keywords
genomics, cancer biology, structural DNA variation, molecular pathology
Summary

Our research mission is to expand the clinical utility of whole genome sequencing in oncology, including developing software for the analysis and interpretation of whole genomes. Our laboratory is also fundamentally interested in the biology and therapeutic implications of complex, noncoding, and structural DNA variation in cancer. Here, we have developed methods for genome analysis and uncovered new classes of somatic mutational processes (Cell 2017, Genome Research 2018, Cell 2020, Nature Genetics 2023).  We have applied these methods to characterize structural genomic alterations in telomere crisis (Nature Communications 2021), homologous recombination deficiency (Nature 2023), and lung adenocarcinomas that lack known oncogenic drivers (Cell Reports 2021).   The laboratory is also interested in how cancer structural DNA variants perturb genome folding, where we have developed a long read sequencing assay (Pore-C) and algorithms (Chromunity) to study high-order 3D interactions in human cells (Nature Biotechnology 2022). 

Lab Website
Is this your profile?

Director, Cancer Genomics Research Program

MD from University of Pennsylvania

PhD from University of Pennsylvania

Fellowship, Brigham and Women's Hospital, Molecular Genetic Pathology

Residency, Massachusetts General Hospital, Pathology

Broad Institute of Harvard and MIT , Matthew Meyerson Lab

Choo, Zi-Ning; Behr, Julie M; Deshpande, Aditya; Hadi, Kevin; Yao, Xiaotong; Tian, Huasong; Takai, Kaori; Zakusilo, George; Rosiene, Joel; Da Cruz Paula, Arnaud; Weigelt, Britta; Setton, Jeremy; Riaz, Nadeem; Powell, Simon N; Busam, Klaus; Shoushtari, Alexander N; Ariyan, Charlotte; Reis-Filho, Jorge; de Lange, Titia; Imieliński, Marcin

Nature genetics. 2023 Dec; 55(12):2139-2148

Setton, Jeremy; Hadi, Kevin; Choo, Zi-Ning; Kuchin, Katherine S; Tian, Huasong; Da Cruz Paula, Arnaud; Rosiene, Joel; Selenica, Pier; Behr, Julie; Yao, Xiaotong; Deshpande, Aditya; Sigouros, Michael; Manohar, Jyothi; Nauseef, Jones T; Mosquera, Juan-Miguel; Elemento, Olivier; Weigelt, Britta; Riaz, Nadeem; Reis-Filho, Jorge S; Powell, Simon N; Imieliński, Marcin

Nature. 2023 Sep; 621(7977):129-137

Hadi, Kevin; Yao, Xiaotong; Behr, Julie M; Deshpande, Aditya; Xanthopoulakis, Charalampos; Tian, Huasong; Kudman, Sarah; Rosiene, Joel; Darmofal, Madison; DeRose, Joseph; Mortensen, Rick; Adney, Emily M; Shaiber, Alon; Gajic, Zoran; Sigouros, Michael; Eng, Kenneth; Wala, Jeremiah A; Wrzeszczyński, Kazimierz O; Arora, Kanika; Shah, Minita; Emde, Anne-Katrin; Felice, Vanessa; Frank, Mayu O; Darnell, Robert B; Ghandi, Mahmoud; Huang, Franklin; Dewhurst, Sally; Maciejowski, John; de Lange, Titia; Setton, Jeremy; Riaz, Nadeem; Reis-Filho, Jorge S; Powell, Simon; Knowles, David A; Reznik, Ed; Mishra, Bud; Beroukhim, Rameen; Zody, Michael C; Robine, Nicolas; Oman, Kenji M; Sanchez, Carissa A; Kuhner, Mary K; Smith, Lucian P; Galipeau, Patricia C; Paulson, Thomas G; Reid, Brian J; Li, Xiaohong; Wilkes, David; Sboner, Andrea; Mosquera, Juan Miguel; Elemento, Olivier; Imielinski, Marcin

Cell. 2020 Oct 01; 183(1):197-210.e32

Deshpande, Aditya S; Ulahannan, Netha; Pendleton, Matthew; Dai, Xiaoguang; Ly, Lynn; Behr, Julie M; Schwenk, Stefan; Liao, Will; Augello, Michael A; Tyer, Carly; Rughani, Priyesh; Kudman, Sarah; Tian, Huasong; Otis, Hannah G; Adney, Emily; Wilkes, David; Mosquera, Juan Miguel; Barbieri, Christopher E; Melnick, Ari; Stoddart, David; Turner, Daniel J; Juul, Sissel; Harrington, Eoghan; Imieliński, Marcin

Nature biotechnology. 2022 Oct; 40(10):1488-1499

Carrot-Zhang, Jian; Yao, Xiaotong; Devarakonda, Siddhartha; Deshpande, Aditya; Damrauer, Jeffrey S; Silva, Tiago Chedraoui; Wong, Christopher K; Choi, Hyo Young; Felau, Ina; Robertson, A Gordon; Castro, Mauro A A; Bao, Lisui; Rheinbay, Esther; Liu, Eric Minwei; Trieu, Tuan; Haan, David; Yau, Christina; Hinoue, Toshinori; Liu, Yuexin; Shapira, Ofer; Kumar, Kiran; Mungall, Karen L; Zhang, Hailei; June-Koo Lee, Jake; Berger, Ashton; Gao, Galen F; Zhitomirsky, Binyamin; Liang, Wen-Wei; Zhou, Meng; Moorthi, Sitapriya; Berger, Alice H; Collisson, Eric A; Zody, Michael C; Ding, Li; Cherniack, Andrew D; Getz, Gad; Elemento, Olivier; Benz, Christopher C; Stuart, Josh; Zenklusen, J C; Beroukhim, Rameen; Chang, Jason C; Campbell, Joshua D; Hayes, D Neil; Yang, Lixing; Laird, Peter W; Weinstein, John N; Kwiatkowski, David J; Tsao, Ming S; Travis, William D; Khurana, Ekta; Berman, Benjamin P; Hoadley, Katherine A; Robine, Nicolas; Meyerson, Matthew; Govindan, Ramaswamy; Imielinski, Marcin

Cell reports. 2021 Feb 23; 34(8):108784

Dewhurst, Sally M; Yao, Xiaotong; Rosiene, Joel; Tian, Huasong; Behr, Julie; Bosco, Nazario; Takai, Kaori K; de Lange, Titia; Imieliński, Marcin

Nature communications. 2021 04 07; 12(1):2093

Imielinski, Marcin; Guo, Guangwu; Meyerson, Matthew

Cell. 2017 01 26; 168(3):460-472.e14

Wala, Jeremiah A; Bandopadhayay, Pratiti; Greenwald, Noah F; O'Rourke, Ryan; Sharpe, Ted; Stewart, Chip; Schumacher, Steve; Li, Yilong; Weischenfeldt, Joachim; Yao, Xiaotong; Nusbaum, Chad; Campbell, Peter; Getz, Gad; Meyerson, Matthew; Zhang, Cheng-Zhong; Imielinski, Marcin; Beroukhim, Rameen

Genome research. 2018 04; 28(4):581-591