Patricia M. and Robert H. Martinsen Professor of Cardiology, Department of Medicine
Professor, Department of Cell Biology
Debunking the concept of one gene-one disease in inheritable arrhythmia death; cellular/molecular mechanisms of arrhythmogenic right ventricular cardiomyopathy and its overlap with other inheritable arrhythmia syndromes.
Our laboratory studies the cellular and molecular mechanisms leading to sudden cardiac death in patients with inheritable arrhythmia syndromes; our primary focus is on arrhythmogenic right ventricular cardiomyopathy (ARVC) and its overlapping syndromes (Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia). We seek to understand the causes of the arrhythmias; develop approaches toward their prevention and treatment; and identify factors that place individuals at risk of sudden death. Our experimental approaches are multidisciplinary and include super-resolution microscopy and other advanced imaging methods, scanning patch clamp, genetically modified animal models, and human induced pluripotent stem cell–derived cardiomyocytes.
Patricia M. and Robert H. Martinsen Professor of Cardiology, Department of Medicine at NYU Grossman School of Medicine
MD from National Autonomous University of Mexico
Nature cardiovascular research. 2023 Jul 01; 2(<prism:issueIdentifier>7):673-692
Journal of clinical investigation. 2023 Mar 15; 133(6):
Methods in cell biology. 2023 Jul; 177:55-81
Annual review of genomics & human genetics. 2022 Aug 31; 23:255-274
Circulation. 2022 Aug 12; 101161CIRCULATIONAHA12206
American journal of physiology. Cell physiology. 2022 Jun 01; 322(6):C1230-C1247
Circulation. 2022 May 10; 145(19):1480-1496