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Meike Dittmann

Meike Dittmann, PhD

Assistant Professor, Department of Microbiology

Keywords
virology, innate immunity, high-content imaging, respiratory viruses, influenza virus
Summary

In our lab we investigate how the human respiratory system battles viral infections. Lower respiratory tract infections are a leading cause of death in the United States and the leading infectious cause of death worldwide, claiming 3.1 million lives each year. Our hope is that a better understanding of the body’s own protection strategies will enable us to develop novel antiviral therapies.

Our main expertise lies in high-content imaging, which we use to monitor subcellular immune system events that occur in response to viral infection. We are particularly interested in events that are triggered by interferons—proteins that act as potent innate immune messengers.

In the first hours of infection, infected cells produce interferons, which alert neighboring cells to immediately activate specific cellular genes, known as interferon-stimulated genes (ISGs). There are several hundred different ISGs that together are a strong force against viruses. However, we know little about what the individual ISGs do.

We study the role of individual ISGs, their antiviral mechanisms, and their contribution to keeping respiratory viruses in check. We are currently working on three main projects:

  • identify and characterize ISGs that inhibit respiratory viruses
  • characterize the role of serpins during virus life cycles
  • develop human model systems for studying respiratory viruses
 
Phone

646-501-4642

Academic office

430 East 29th Street

3rd floor, Room 313

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Assistant Professor, Department of Microbiology

Fellowship, NIH/NIAID, K99/R00 Pathway to Independence

Fellowship, The Rockefeller University, Women & Science Postdoctoral Fellowship

Fellowship, The Rockefeller University, Pilot project grant - Center for Clinical and Translational Science and Helmsley Charitable Trust/Center on Disorders of the Digestive System

Fellowship, Deutsche Forschungsgemeinschaft (German Research Foundation), Postdoctoral Fellowship

Dittmann, Meike; Hoffmann, Hans-Heinrich; Scull, Margaret A; Gilmore, Rachel H; Bell, Kierstin L; Ciancanelli, Michael; Wilson, Sam J; Crotta, Stefania; Yu, Yingpu; Flatley, Brenna; Xiao, Jing W; Casanova, Jean-Laurent; Wack, Andreas; Bieniasz, Paul D; Rice, Charles M

Cell. 2015 Feb 12; 160(4):631-643

Yao, Hui; Dittmann, Meike; Peisley, Alys; Hoffmann, Hans-Heinrich; Gilmore, Rachel H; Schmidt, Tobias; Schmid-Burgk, Jonathan L; Hornung, Veit; Rice, Charles M; Hur, Sun

Molecular cell. 2015 May 07; 58(3):541-548

Seifert, Leon Louis; Si, Clara; Saha, Debjani; Sadic, Mohammad; de Vries, Maren; Ballentine, Sarah; Briley, Aaron; Wang, Guojun; Valero-Jimenez, Ana M; Mohamed, Adil; Schaefer, Uwe; Moulton, Hong M; García-Sastre, Adolfo; Tripathi, Shashank; Rosenberg, Brad R; Dittmann, Meike

PLoS pathogens. 2019 Nov 04; 15(11):e1007634

Hoffmann, Franziska S; Schmidt, Andreas; Dittmann Chevillotte, Meike; Wisskirchen, Christian; Hellmuth, Johannes; Willms, Simone; Gilmore, Rachel H; Glas, Jurgen; Folwaczny, Matthias; Muller, Tobias; Berg, Thomas; Spengler, Ulrich; Fitzmaurice, Karen; Kelleher, Dermot; Reisch, Nicole; Rice, Charles M; Endres, Stefan; Rothenfusser, Simon

Hepatology. 2015 Feb; 61(2):460-70

Schneider, William M; Chevillotte, Meike Dittmann; Rice, Charles M

Annual review of immunology. 2014 Jul; 32:513-45

Antiviral Therapy, Drug Resistance and Computed Resistance Profiling

Michel, D; Chevillotte, Meike; Mertens, T

Cytomegaloviruses : from molecular pathogenesis to intervention. [Wymondham] : Caister Academic Press, [2013]. p.402-423. (2502442)

Schauflinger, Martin; Fischer, Daniela; Schreiber, Andreas; Chevillotte, Meike; Walther, Paul; Mertens, Thomas; von Einem, Jens

Journal of virology. 2011 Apr; 85(8):3821-32

Chevillotte, Meike; Ersing, Ina; Mertens, Thomas; von Einem, Jens

Antimicrobial agents & chemotherapy. 2010 Dec; 54(12):5004-11