In our lab we investigate how the human respiratory system battles viral infections. Lower respiratory tract infections are a leading cause of death in the United States and the leading infectious cause of death worldwide, claiming 3.1 million lives each year. Our hope is that a better understanding of the body’s own protection strategies will enable us to develop novel antiviral therapies.
Our main expertise lies in high-content imaging, which we use to monitor subcellular immune system events that occur in response to viral infection. We are particularly interested in events that are triggered by interferons—proteins that act as potent innate immune messengers.
In the first hours of infection, infected cells produce interferons, which alert neighboring cells to immediately activate specific cellular genes, known as interferon-stimulated genes (ISGs). There are several hundred different ISGs that together are a strong force against viruses. However, we know little about what the individual ISGs do.
We study the role of individual ISGs, their antiviral mechanisms, and their contribution to keeping respiratory viruses in check. We are currently working on three main projects:
- identify and characterize ISGs that inhibit respiratory viruses
- characterize the role of serpins during virus life cycles
- develop human model systems for studying respiratory viruses
Assistant Professor, Department of Microbiology
Fellowship, NIH/NIAID, K99/R00 Pathway to Independence
Fellowship, The Rockefeller University, Women & Science Postdoctoral Fellowship
Fellowship, The Rockefeller University, Pilot project grant - Center for Clinical and Translational Science and Helmsley Charitable Trust/Center on Disorders of the Digestive System
Fellowship, Deutsche Forschungsgemeinschaft (German Research Foundation), Postdoctoral Fellowship
Cell. 2015 Feb 12; 160(4):631-643
Molecular cell. 2015 May 07; 58(3):541-548
Hepatology. 2015 Feb; 61(2):460-470
Annual review of immunology. 2014; 32:513-545
Antiviral Therapy, Drug Resistance and Computed Resistance Profiling
Cytomegaloviruses : from molecular pathogenesis to intervention. [Wymondham] : Caister Academic Press, . p.402-423. (2502442)
Journal of virology. 2011 Apr; 85(8):3821-3832
Antimicrobial agents & chemotherapy. 2010 Dec; 54(12):5004-5011
Antiviral research. 2010 Feb; 85(2):318-327