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Melvin G. Rosenfeld

Melvin G. Rosenfeld, PhD

Senior Associate Dean for Medical Education

Associate Professor, Department of Cell Biology

sorting of ER and lysosomal membrane proteins

This laboratory studies the biosynthesis and sorting of two model proteins that are synthesized in membrane-bound ribosomes but have different subcellular destinations: 1) a rat liver microsomal esterase that is a permanent resident of the endoplasmic reticulum lumen and 2) a lysosomal membrane protein that is also in significant concentrations in the endosomal membranes. The goals of this research are to elucidate the nature of the signals and the sorting mechanisms that lead to the retention of some proteins in the endoplasmic reticulum and addresses other proteins to the lysosomal membrane. Using biochemical and immunocytochemical techniques, we work with cloning cDNAs for these proteins, constructing specific mutations, and analyzing the sorting of normal and mutated polypeptides expressed in transfected cells.




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Senior Associate Dean for Medical Education

PhD from SUNY-Downstate

Oh, So-Young; Dorsainville, Gregory A; Harnik, Victoria; Rapkiewicz, Amy; Shearer, Brian; Ramirez, Kristen; Alfaro, Veronica; Rosenfeld, Mel

FASEB journal. 2020 Apr; 34(S1):1

Brown, David R; Warren, Jamie B; Hyderi, Abbas; Drusin, Ronald E; Moeller, Jeremy; Rosenfeld, Melvin; Orlander, Philip R; Yingling, Sandra; Call, Stephanie; Terhune, Kyla; Bull, Janet; Englander, Robert; Wagner, Dianne P

Academic medicine. 2017 06; 92(6):774-779

Leong, Shou Ling; Cangiarella, Joan; Fancher, Tonya; Dodson, Lisa; Grochowski, Colleen; Harnik, Vicky; Hustedde, Carol; Jones, Betsy; Kelly, Christina; Macerollo, Allison; Reboli, Annette C; Rosenfeld, Melvin; Rundell, Kristen; Thompson, Tina; Whyte, Robert; Pusic, Martin

Medical education online. 2017 Jun; 22(1):1396172

Abramson, Steven B; Jacob, Dianna; Rosenfeld, Melvin; Buckvar-Keltz, Lynn; Harnik, Victoria; Francois, Fritz; Rivera, Rafael; Hopkins, Mary Ann; Triola, Marc; Grossman, Robert I

New England journal of medicine. 2013 Sep 19; 369(12):1085-7

Abramson, Steven B; Rosenfeld, Mel

Academic medicine. 2010 Sep; 85(9 Suppl):S380-6

Lopez, Gregory J; Rosenfeld, Melvin G

Virtual mentor : VM. 2003 Dec 01; 5(12):

Levin, M C; Krichavsky, M; Berk, J; Foley, S; Rosenfeld, M; Dalmau, J; Chang, G; Posner, J B; Jacobson, S

Annals of neurology. 1998 Jul; 44(1):87-98

Brooks PC; Montgomery AM; Rosenfeld M; Reisfeld RA; Hu T; Klier G; Cheresh DA

Cell. 1994 Dec 30; 79(7):1157-64