Melvin G. Rosenfeld

Melvin G. Rosenfeld

Senior Associate Dean for Medical Education

Associate Professor, Department of Cell Biology

Keywords
sorting of ER and lysosomal membrane proteins
Summary

This laboratory studies the biosynthesis and sorting of two model proteins that are synthesized in membrane-bound ribosomes but have different subcellular destinations: 1) a rat liver microsomal esterase that is a permanent resident of the endoplasmic reticulum lumen and 2) a lysosomal membrane protein that is also in significant concentrations in the endosomal membranes. The goals of this research are to elucidate the nature of the signals and the sorting mechanisms that lead to the retention of some proteins in the endoplasmic reticulum and addresses other proteins to the lysosomal membrane. Using biochemical and immunocytochemical techniques, we work with cloning cDNAs for these proteins, constructing specific mutations, and analyzing the sorting of normal and mutated polypeptides expressed in transfected cells.

 

Phone

212-263-2195

Academic office

545 First Avenue

Sixth Floor

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Associate Professor, Department of Cell Biology

Senior Associate Dean for Medical Education

Brown, David R; Warren, Jamie B; Hyderi, Abbas; Drusin, Ronald E; Moeller, Jeremy; Rosenfeld, Melvin; Orlander, Philip R; Yingling, Sandra; Call, Stephanie; Terhune, Kyla; Bull, Janet; Englander, Robert; Wagner, Dianne P

Academic medicine. 2017 Jun; 92(6):774-779

Abramson, Steven B; Jacob, Dianna; Rosenfeld, Melvin; Buckvar-Keltz, Lynn; Harnik, Victoria; Francois, Fritz; Rivera, Rafael; Hopkins, Mary Ann; Triola, Marc; Grossman, Robert I

New England journal of medicine. 2013 Sep 19; 369(12):1085-1087

Abramson, Steven B; Rosenfeld, Mel

Academic medicine. 2010 Sep; 85(9 Suppl):S380-S386

Lopez, Gregory J; Rosenfeld, Melvin G

Virtual mentor : VM. 2003 Dec 1; 5(12):?-?

Levin, M C; Krichavsky, M; Berk, J; Foley, S; Rosenfeld, M; Dalmau, J; Chang, G; Posner, J B; Jacobson, S

Annals of neurology. 1998 Jul; 44(1):87-98

CHARACTERIZATION OF RAB BINDING-PROTEINS THAT MAY MEDIATE THE ACTIONS OF RAB11 AND RAB8 [Meeting Abstract]

REN, M; ZENG, J; GRAVOTTA, D; MORIMOTO, T; ROSENFELD, M; DELEMOSCHIARANDINI, C; TEMPST, P; ERDJUMENTBROMAGE, H; LUI, M; ADESNIK, M; SABATINI, DD

Molecular biology of the cell. 1995 Nov; 6(23):690-690

Brooks PC; Montgomery AM; Rosenfeld M; Reisfeld RA; Hu T; Klier G; Cheresh DA

Cell. 1994 Dec 30; 79(7):1157-1164

Philips MR; Pillinger MH; Staud R; Volker C; Rosenfeld MG; Weissmann G; Stock JB

Science. 1993 Feb 12; 259(5097):977-980