Michael J. Garabedian

Michael J. Garabedian, PhD

Professor, Department of Microbiology

Professor, Department of Urology

Keywords
signal transduction and transcriptional regulation by steroid receptors, molecular, cellular, & translational neuroscience
Summary

Steroid hormone receptors are ligand-regulated transcription factors that control diverse physiological and developmental processes. In addition, estrogen and androgen receptors (ER and AR) are implicated in the etiology of breast and prostate cancer, respectively, whereas the glucocorticoid receptor (GR) is an important therapeutic target for cancer and inflammatory diseases. The goal of my laboratory is to elucidate the mechanism of signal transduction and transcriptional regulation by these receptors. Specifically, the lab is interested: 1) How molecular chaperones regulate steroid receptor action; 2) how transcriptional regulatory molecules (coactivators and corepressors) modulate ER, GR and AR transcriptional activity and the role of steroid receptor phosphorylation in the recruitment of coactivators and corepressors, 3) how Rho GTPases and the actin cytoskeleton regulate steroid receptor transcriptional response, and 4) the mechanism of GR-induced cell growth arrest and apoptosis. We are using genetic (mouse knock-outs and knock-ins), biochemical (microarrays and high-throughput screening of small molecules that disrupt receptor:coactivator interaction) as well as cell biological strategies (studying macromolecular complexes using color variants of GFP) to elucidate the mechanism of ER, AR and GR function in vivo. Understanding the mechanism of steroid receptor-regulated gene expression may reveal novel points of intervention to be exploited in the development of new therapies for steroid-dependent malignancies, such as breast and prostate cancer.

 

Phone

212-263-7662

Academic office

450 East 29th Street

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Professor, Department of Microbiology

Professor, Department of Urology

Course Director

Fellowship, University of California, San Francisco, Mechanism of Glucocotricoid Receptor

PhD from Brandeis University

Mita, Paolo; Savas, Jeffrey N; Briggs, Erica M; Ha, Susan; Gnanakkan, Veena; Yates, John R 3rd; Robins, Diane M; David, Gregory; Boeke, Jef D; Garabedian, Michael J; Logan, Susan K

Journal of biological chemistry. 2016 Dec 02; 291(49):25516-25528

Basu-Roy, Upal; Han, Eugenia; Rattanakorn, Kirk; Gadi, Abhilash; Verma, Narendra; Maurizi, Giulia; Gunaratne, Preethi H; Coarfa, Cristian; Kennedy, Oran D; Garabedian, Michael J; Basilico, Claudio; Mansukhani, Alka

Oncotarget. 2016 Sep 20; 7(38):60954-60970

Wang, Yu; Dehigaspitiya, Dilani C; Levine, Paul M; Profit, Adam A; Haugbro, Michael; Imberg-Kazdan, Keren; Logan, Susan K; Kirshenbaum, Kent; Garabedian, Michael J

Cancer research. 2016 Sep 01; 76(17):5124-5132

Wang, Yu; Ledet, Russell J; Imberg-Kazdan, Keren; Logan, Susan K; Garabedian, Michael J

Oncotarget. 2016 Aug 2; 7(31):49268-49280

Shrestha, Elina; Hussein, Maryem A; Savas, Jeffery N; Ouimet, Mireille; Barrett, Tessa J; Leone, Sarah; Yates, John R 3rd; Moore, Kathryn J; Fisher, Edward A; Garabedian, Michael J

Journal of biological chemistry. 2016 May 20; 291(21):11172-11184

Ouimet, Mireille; Hennessy, Elizabeth J; van Solingen, Coen; Koelwyn, Graeme J; Hussein, Maryem A; Ramkhelawon, Bhama; Rayner, Katey J; Temel, Ryan E; Perisic, Ljubica; Hedin, Ulf; Maegdefessel, Lars; Garabedian, Michael J; Holdt, Lesca M; Teupser, Daniel; Moore, Kathryn J

Arteriosclerosis, thrombosis, & vascular biology. 2016 May; 36(5):942-951

Arango-Lievano, Margarita; Lambert, W Marcus; Bath, Kevin G; Garabedian, Michael J; Chao, Moses V; Jeanneteau, Freddy

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 Dec 22; 112(51):15737-15742

Jones, Courtney L; Gearheart, Christy M; Fosmire, Susan; Delgado-Martin, Cristina; Evensen, Nikki A; Bride, Karen; Waanders, Angela J; Pais, Faye; Wang, Jinhua; Bhatla, Teena; Bitterman, Danielle S; de Rijk, Simone R; Bourgeois, Wallace; Dandekar, Smita; Park, Eugene; Burleson, Tamara M; Madhusoodhan, Pillai Pallavi; Teachey, David T; Raetz, Elizabeth A; Hermiston, Michelle L; Muschen, Markus; Loh, Mignon L; Hunger, Stephen P; Zhang, Jinghui; Garabedian, Michael J; Porter, Christopher C; Carroll, William L

Blood. 2015 Nov 05; 126(19):2202-2212