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Michael J. Garabedian

Michael J. Garabedian

Professor, Department of Microbiology

Professor, Department of Urology

Keywords
signal transduction and transcriptional regulation by nuclear receptors, molecular, cellular, & translational neuroscience, regulation of atherosclerosis by LXR, targeting therapy resistant prostate cancer
Summary

Nuclear receptors are ligand-regulated transcription factors that control diverse physiological and developmental processes. The focus of my laboratory is to understand the mechanism of signal transduction and transcriptional regulation by nuclear hormone receptors, including LXR alpha in cardiovascular disease, the glucocorticoid receptor (GR) in immune and neuronal function, and the androgen receptor (AR) in prostate cancer. We use state-of-the-art genetic (mouse knock-outs and knock-ins and CRISPR-Cas9 gene editing), biochemical (RNA-/ ChIP-seq and high-throughput siRNA and small molecules screens) as well as proteomic strategies to identify macromolecular complexes important in nuclear receptor activity to elucidate the mechanism of LXR, AR and GR function in vivo. Characterizing factors that control nuclear receptor activity can lead to potential new therapeutic strategies for prostate cancer, atherosclerosis as well as stress related anxiety, and depression.

 

Phone

212-263-7662

Academic office

450 East 29th Street

Room 324

New York, NY 10016

Lab Website
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Fellowship, University of California, San Francisco, Mechanism of Glucocotricoid Receptor

Vurusaner, Beyza; Thevkar-Nages, Prashanth; Kaur, Ravneet; Giannarelli, Chiara; Garabedian, Michael J; Fisher, Edward A

Scientific reports. 2022 Jul 14; 12(1):12031

Dromard, Yann; Arango-Lievano, Margarita; Borie, Amelie; Dedin, Maheva; Fontanaud, Pierre; Torrent, Joan; Garabedian, Michael J; Ginsberg, Stephen D; Jeanneteau, Freddy

Acta neuropathologica communications. 2022 06 22; 10(1):91

Ruff, Sophie E; Vasilyev, Nikita; Nudler, Evgeny; Logan, Susan K; Garabedian, Michael J

Communications biology. 2021 Oct 25; 4(1):1221

Nakamura, Ryosuke; Bing, Renjie; Doyle, Carina P; Garabedian, Michael J; Branski, Ryan C

Experimental cell research. 2021 Jun 01; 112681

Voisin, Maud; Shrestha, Elina; Rollet, Claire; Nikain, Cyrus A; Josefs, Tatjana; Mahé, Mélanie; Barrett, Tessa J; Chang, Hye Rim; Ruoff, Rachel; Schneider, Jeffrey A; Garabedian, Michela L; Zoumadakis, Chris; Yun, Chi; Badwan, Bara; Brown, Emily J; Mar, Adam C; Schneider, Robert J; Goldberg, Ira J; Pineda-Torra, Inés; Fisher, Edward A; Garabedian, Michael J

Communications biology. 2021 Mar 26; 4:420

Ledet, Russell J; Ruff, Sophie E; Wang, Yu; Nayak, Shruti; Schneider, Jeffrey A; Ueberheide, Beatrix; Logan, Susan K; Garabedian, Michael J

Communications biology. 2021 Jan 04; 4(1):36

Nakamura, Ryosuke; Mukudai, Shigeyuki; Bing, Renjie; Garabedian, Michael J; Branski, Ryan C

Scientific reports. 2020 Nov 24; 10(1):20458