Michael J. Garabedian

Michael J. Garabedian

Professor, Department of Microbiology

Professor, Department of Urology

signal transduction and transcriptional regulation by nuclear receptors, molecular, cellular, & translational neuroscience, regulation of atherosclerosis by LXR, targeting therapy resistant prostate cancer

Nuclear receptors are ligand-regulated transcription factors that control diverse physiological and developmental processes. The focus of my laboratory is to understand the mechanism of signal transduction and transcriptional regulation by nuclear hormone receptors, including LXR alpha in cardiovascular disease, the glucocorticoid receptor (GR) in immune and neuronal function, and the androgen receptor (AR) in prostate cancer. We use state-of-the-art genetic (mouse knock-outs and knock-ins and CRISPR-Cas9 gene editing), biochemical (RNA-/ ChIP-seq and high-throughput siRNA and small molecules screens) as well as proteomic strategies to identify macromolecular complexes important in nuclear receptor activity to elucidate the mechanism of LXR, AR and GR function in vivo. Characterizing factors that control nuclear receptor activity can lead to potential new therapeutic strategies for prostate cancer, atherosclerosis as well as stress related anxiety, and depression.




Academic office

450 East 29th Street

Room 324

New York, NY 10016

Lab Website
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Professor, Department of Microbiology

Professor, Department of Urology

Course Director

Fellowship, University of California, San Francisco, Mechanism of Glucocotricoid Receptor

Weber, Hannah; Garabedian, Michael J

Steroids. 2017 Nov 21; ?-?

Garabedian, Michael J; Harris, Charles A; Jeanneteau, Freddy

F1000Research. 2017; 6:1208-1208

Mita, Paolo; Savas, Jeffrey N; Briggs, Erica M; Ha, Susan; Gnanakkan, Veena; Yates, John R 3rd; Robins, Diane M; David, Gregory; Boeke, Jef D; Garabedian, Michael J; Logan, Susan K

Journal of biological chemistry. 2016 Dec 02; 291(49):25516-25528

Basu-Roy, Upal; Han, Eugenia; Rattanakorn, Kirk; Gadi, Abhilash; Verma, Narendra; Maurizi, Giulia; Gunaratne, Preethi H; Coarfa, Cristian; Kennedy, Oran D; Garabedian, Michael J; Basilico, Claudio; Mansukhani, Alka

Oncotarget. 2016 Sep 20; 7(38):60954-60970

Wang, Yu; Dehigaspitiya, Dilani C; Levine, Paul M; Profit, Adam A; Haugbro, Michael; Imberg-Kazdan, Keren; Logan, Susan K; Kirshenbaum, Kent; Garabedian, Michael J

Cancer research. 2016 Sep 01; 76(17):5124-5132

Wang, Yu; Ledet, Russell J; Imberg-Kazdan, Keren; Logan, Susan K; Garabedian, Michael J

Oncotarget. 2016 Aug 2; 7(31):49268-49280

Shrestha, Elina; Hussein, Maryem A; Savas, Jeffery N; Ouimet, Mireille; Barrett, Tessa J; Leone, Sarah; Yates, John R 3rd; Moore, Kathryn J; Fisher, Edward A; Garabedian, Michael J

Journal of biological chemistry. 2016 May 20; 291(21):11172-11184

Ouimet, Mireille; Hennessy, Elizabeth J; van Solingen, Coen; Koelwyn, Graeme J; Hussein, Maryem A; Ramkhelawon, Bhama; Rayner, Katey J; Temel, Ryan E; Perisic, Ljubica; Hedin, Ulf; Maegdefessel, Lars; Garabedian, Michael J; Holdt, Lesca M; Teupser, Daniel; Moore, Kathryn J

Arteriosclerosis, thrombosis, & vascular biology. 2016 May; 36(5):942-951