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Michael J. Garabedian

Michael J. Garabedian

Professor, Department of Microbiology

Professor, Department of Urology

signal transduction and transcriptional regulation by nuclear receptors, molecular, cellular, & translational neuroscience, regulation of atherosclerosis by LXR, targeting therapy resistant prostate cancer

Nuclear receptors are ligand-regulated transcription factors that control diverse physiological and developmental processes. The focus of my laboratory is to understand the mechanism of signal transduction and transcriptional regulation by nuclear hormone receptors, including LXR alpha in cardiovascular disease, the glucocorticoid receptor (GR) in immune and neuronal function, and the androgen receptor (AR) in prostate cancer. We use state-of-the-art genetic (mouse knock-outs and knock-ins and CRISPR-Cas9 gene editing), biochemical (RNA-/ ChIP-seq and high-throughput siRNA and small molecules screens) as well as proteomic strategies to identify macromolecular complexes important in nuclear receptor activity to elucidate the mechanism of LXR, AR and GR function in vivo. Characterizing factors that control nuclear receptor activity can lead to potential new therapeutic strategies for prostate cancer, atherosclerosis as well as stress related anxiety, and depression.




Academic office

450 East 29th Street

Room 324

New York, NY 10016

Lab Website
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Professor, Department of Microbiology

Professor, Department of Urology

Course Director

Fellowship, University of California, San Francisco, Mechanism of Glucocotricoid Receptor

Mukudai, Shigeyuki; Hiwatashi, Nao; Bing, Renjie; Garabedian, Michael; Branski, Ryan C

Laryngoscope. 2019 May; 129(5):E187-E193

Becares, Natalia; Gage, Matthew C; Voisin, Maud; Shrestha, Elina; Martin-Gutierrez, Lucia; Liang, Ning; Louie, Rikah; Pourcet, Benoit; Pello, Oscar M; Luong, Tu Vinh; Goñi, Saioa; Pichardo-Almarza, Cesar; Røberg-Larsen, Hanne; Diaz-Zuccarini, Vanessa; Steffensen, Knut R; O'Brien, Alastair; Garabedian, Michael J; Rombouts, Krista; Treuter, Eckardt; Pineda-Torra, Inés

Cell reports. 2019 Jan 22; 26(4):984-995.e6

Wang, Yu; Schafler, Eric D; Thomas, Phillip A; Ha, Susan; David, Gregory; Adney, Emily; Garabedian, Michael J; Lee, Peng; Logan, Susan K

Oncotarget. 2019 Jan 22; 10(7):707-716

Jeanneteau, Freddy; Borie, Amélie; Chao, Moses V; Garabedian, Michael J

Neuroendocrinology. 2018 Dec 20;

Schneider, Jeffrey A; Craven, Timothy W; Kasper, Amanda C; Yun, Chi; Haugbro, Michael; Briggs, Erica M; Svetlov, Vladimir; Nudler, Evgeny; Knaut, Holger; Bonneau, Richard; Garabedian, Michael J; Kirshenbaum, Kent; Logan, Susan K

Nature communications. 2018 10 23; 9(1):4396

Shrestha, Elina; Voisin, Maud; Barrett, Tessa J; Nishi, Hitoo; Cantor, David J; Hussein, Maryem A; David, Gregory; Pineda-Torra, Ines; Fisher, Edward A; Garabedian, Michael J : the preprint server for biology. 2018 Jul 06;

Weber, Hannah; Garabedian, Michael J

Steroids. 2018 05; 133:8-14

Evaluating the effects of HIPK2 inhibition on castration-resistant prostate cancer cells [Meeting Abstract]

Camacho-Hernandez, E M; Thomas, P; Ledet, R; Garabedian, M J; Logan, S K

FASEB journal. 2018 April; Conference:(Experimental):