Michele Pagano

Michele Pagano, MD

Chair, Department of Biochemistry and Molecular Pharmacology

May Ellen and Gerald Jay Ritter Professor of Oncology, Department of Biochemistry and Molecular Pharmacology

Keywords
cell cycle control and ubiquitin-mediated degradation, cancer, genome integrity
Summary

Our laboratory explores the roles that the ubiquitin system plays in fundamental cellular processes, such as cell growth, proliferation, and the DNA damage response. Our group is also committed to understanding how the deregulation of this regulatory network contributes to malignant transformation. 

Phone

212-263-5322

Fax

212-263-5107

Academic office

The Alexandria Center of Life, 450 East 29th Street

East Tower, 802

New York, NY 10016

Lab Website
Pagano Lab
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Positions

May Ellen and Gerald Jay Ritter Professor of Oncology, Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine

Chair, Department of Biochemistry and Molecular Pharmacology

Graduate Education

MD from University of Naples Federico II

Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells

Tsunematsu, Takaaki; Mouri, Yasuhiro; Shao, Wenhua; Arakaki, Rieko; Ruppert, Jan G; Murano, Kensaku; Ishimaru, Naozumi; Guardavaccaro, Daniele; Pagano, Michele; Kudo, Yasusei

Science signaling. 2025 Feb 18; 18(874):eadg4626

Stabilization of GTSE1 by cyclin D1-CDK4/6 promotes cell proliferation: relevance in cancer prognosis

García-Vázquez, Nelson; González-Robles, Tania J; Lane, Ethan; Spasskaya, Daria; Zhang, Qingyue; Kerzhnerman, Marc; Jeong, YeonTae; Collu, Marta; Simoneschi, Daniele; Ruggles, Kelly V; Rona, Gergely; Pagano, Michele; Kaisari, Sharon

bioRxiv.org : the preprint server for biology. 2025 Jan 23;

The FBXO45-GEF-H1 axis controls germinal center formation and B-cell lymphomagenesis

Sahasrabuddhe, Anagh A; Chen, Xiaofei; Ma, Kaiyu; Wu, Rui; Liang, Huan-Chang; Kapoor, Richa; Chhipa, Rishi R; Onder, Ozlem; McFetridge, Courtney; Van Arnam, John S; Zhang, Xiao; Morrissette, Jennifer J D; Pillai, Vinodh; Li, Marilyn M; Szankasi, Philippe; Basrur, Venkatesha; Conlon, Kevin P; Raabe, Tobias D; Bailey, Nathanael G; Hogaboam, Cory M; Rottapel, Robert; Kim, Junhyong; López, Cristina; Schlesner, Matthias; Siebert, Reiner; Dreval, Kostiantyn; Morin, Ryan D; Moro, Loredana; Pagano, Michele; Staudt, Louis M; Lim, Megan S; Elenitoba-Johnson, Kojo S J

Cancer discovery. 2025 Jan 17;

Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress

Cao, Shiyun; Garcia, Sheena Faye; Shi, Huigang; James, Ellie I; Kito, Yuki; Shi, Hui; Mao, Haibin; Kaisari, Sharon; Rona, Gergely; Deng, Sophia; Goldberg, Hailey V; Ponce, Jackeline; Ueberheide, Beatrix; Lignitto, Luca; Guttman, Miklos; Pagano, Michele; Zheng, Ning

Cell. 2024 Dec 26; 187(26):7568-7584.e22

FBXO38 is dispensable for PD-1 regulation

Dibus, Nikol; Salyova, Eva; Kolarova, Karolina; Abdirov, Alikhan; Pagano, Michele; Stepanek, Ondrej; Cermak, Lukas

EMBO reports. 2024 Oct; 25(10):4206-4225

Identification of a novel alternative splicing isoform of the Hippo kinase STK3/MST2 with impaired kinase and cell growth suppressing activities

Rodrigues, Ana Maria; Paula Zen Petisco Fiore, Ana; Guardia, Gabriela D A; Tomasin, Rebeka; Azevedo Reis Teixeira, André; Giordano, Ricardo Jose; Schechtman, Deborah; Pagano, Michele; Galante, Pedro A F; Bruni-Cardoso, Alexandre

Oncogene. 2024 Sep; 43(39):2938-2950

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

Nguyen-Dien, Giang Thanh; Townsend, Brendan; Kulkarni, Prajakta Gosavi; Kozul, Keri-Lyn; Ooi, Soo Siang; Eldershaw, Denaye N; Weeratunga, Saroja; Liu, Meihan; Jones, Mathew Jk; Millard, S Sean; Ng, Dominic Ch; Pagano, Michele; Bonfim-Melo, Alexis; Schneider, Tobias; Komander, David; Lazarou, Michael; Collins, Brett M; Pagan, Julia K

EMBO reports. 2024 Aug; 25(8):3324-3347

CDK-independent role of D-type cyclins in regulating DNA mismatch repair

Rona, Gergely; Miwatani-Minter, Bearach; Zhang, Qingyue; Goldberg, Hailey V; Kerzhnerman, Marc A; Howard, Jesse B; Simoneschi, Daniele; Lane, Ethan; Hobbs, John W; Sassani, Elizabeth; Wang, Andrew A; Keegan, Sarah; Laverty, Daniel J; Piett, Cortt G; Pongor, Lorinc S; Xu, Miranda Li; Andrade, Joshua; Thomas, Anish; Sicinski, Piotr; Askenazi, Manor; Ueberheide, Beatrix; Fenyö, David; Nagel, Zachary D; Pagano, Michele

Molecular cell. 2024 Apr 04; 84(7):1224-1242.e13

See All Publications (256)

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