Michelle Krogsgaard

Michelle Krogsgaard

Perlmutter Cancer Center

Associate Professor, Department of Pathology

Keywords
T-cell recognition and sensitivity, cancer immunology, autoimmunity, receptor signaling, biophysics, cancer
Summary

The goal of the Krogsgaard laboratory is to understand the molecular and cellular events that contribute to T-cell sensitivity to `self' (cancer) antigens. To accomplish this we employ advanced and highly innovative methods that combine state-of-the-art biophysical methods for characterizing protein-protein interactions e.g. surface plasmon resonance (SPR), biomembrane force probe X-ray crystallography, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy with imaging methods (single molecule imaging and FRET) and transgenic TCR technologies which makes our research highly interdisciplinary in its nature. Our research is important not only for understanding the activation of signaling pathways important for T cell function but also for the purpose of modulating signaling through the TCR pharmacologically in new and innovative approaches that can be applied to immunotherapy approaches. This is with the purpose of increasing the sensitivity of T-cells in patients with cancer or HIV or decreasing the sensitivity in patients with autoimmune diseases (multiple sclerosis or diabetes). Supported by the Pew Trust, Cancer Research Institute (CRI), The Arthritis Foundation; New York Chapter, American Cancer Society (ACS), PS-ON/NCI/NIH and NIGMS/NIH.

Phone

212-263-9266

Academic office

550 First Avenue, Smilow Research Building

13th floor, Room 1311

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Associate Professor, Department of Pathology

Fellowship, Stanford University, Postdoctoral Fellow

Moogk, Duane; Zhong, Shi; Yu, Zhiya; Liadi, Ivan; Rittase, William; Fang, Victoria; Dougherty, Janna; Perez-Garcia, Arianne; Osman, Iman; Zhu, Cheng; Varadarajan, Navin; Restifo, Nicholas P; Frey, Alan B; Krogsgaard, Michelle

Journal of immunology (1950). 2016 Jul 15; 197(2):644-654

Natarajan, Aswin; Nadarajah, Vidushan; Felsovalyi, Klara; Wang, Wenjuan; Jeyachandran, Vivian R; Wasson, Riley A; Cardozo, Timothy; Bracken, Clay; Krogsgaard, Michelle

Cell reports. 2016 Mar 29; 14(12):2833-2845

Zhong, Shi; Malecek, Karolina; Johnson, Laura A; Yu, Zhiya; Vega-Saenz de Miera, Eleazar; Darvishian, Farbod; McGary, Katelyn; Huang, Kevin; Boyer, Josh; Corse, Emily; Shao, Yongzhao; Rosenberg, Steven A; Restifo, Nicholas P; Osman, Iman; Krogsgaard, Michelle

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2013 Apr 23; 110(17):6973-6978

Liu, Baoyu; Zhong, Shi; Malecek, Karolina; Johnson, Laura A; Rosenberg, Steven A; Zhu, Cheng; Krogsgaard, Michelle

European journal of immunology. 2014 Jan; 44(1):239-250

Malecek, Karolina; Grigoryan, Arsen; Zhong, Shi; Gu, Wei Jun; Johnson, Laura A; Rosenberg, Steven A; Cardozo, Timothy; Krogsgaard, Michelle

Journal of immunology (1950). 2014 Sep 01; 193(5):2587-2599CD004345

Wang, Wenjuan; Li, Tianqi; Felsovalyi, Klara; Chen, Chunlai; Cardozo, Timothy; Krogsgaard, Michelle

ACS chemical biology. 2014 Sep 19; 9(9):2165-2172

Wei, Fang; Zhong, Shi; Ma, Zhengyu; Kong, Hong; Medvec, Andrew; Ahmed, Rafi; Freeman, Gordon J; Krogsgaard, Michelle; Riley, James L

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2013 Jul 02; 110(27):E2480-E2489e56302

Moogk, Duane; da Silva, Ines; Ma, Michelle W; Friedman, Erica B; de Miera, Eleazar; Darvishian, Farbod; Scanlon, Patrick; Perez-Garcia, Arianne; Pavlick, Anna C; Bhardwaj, Nina; Christos, Paul J; Osman, Iman; Krogsgaard, Michelle

Journal of translational medicine. 2014 Dec 10; 12:342-342