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Moses V. Chao

Moses V. Chao, PhD

Neuroscience Institute

Professor, Department of Cell Biology

Professor, Department of Neuroscience and Physiology

Professor, Department of Psychiatry

metabolism, molecular, cellular, & translational neuroscience, molecular mechanisms of trophic factor action

The generation and differentiation of neurons and glial cells are dependent upon cell-cell interactions mediated by a wide variety of growth factors and cytokines. The laboratory is interested in receptor-mediated mechanisms that direct cell differentiation versus cell proliferation in the nervous system. A major goal is to identify the biochemical steps that provide specificity in NGF signaling. Control of cell survival and death by neurotrophins is dictated by an unusual transduction system consisting of two transmembrane receptors, the TrkA tyrosine kinase and the p75 neurotrophin receptor, a member of the TNF receptor superfamily. Members of the NGF family are responsible for neuronal cell survival by activating Trk tyrosine kinases. However, NGF can have the opposite effect, promoting a cell death signal through the p75 receptor. NGF can induce apoptosis of mature oligodendrocytes cultured from rat cerebral cortex. NGF binding to oligodendrocytes expressing the p75 receptor, but not TrkA, resulted in an increase c-jun kinase and caspase activity. Therefore, NGF has the ability of promoting cell survival and cell death in specific cell types through novel signaling mechanisms involving TrkA and p75 receptors. The structural and biochemical features of these two receptors are being defined together with their intracellular signaling mechanisms.

In addition to receptor signal transduction, cell cycle regulation of CNS progenitor cells is being studied. For example, extensive changes in the levels of CDK2 kinase and the cell cycle inhibitor, p27Kip, accompany the differentiation of oligodendrocyte progenitor cells. CDK inhibitors such as p27 negatively regulate G1 phase progression by disrupting cyclin D-CDK4 complexes and cyclin E-CDK2 complexes. The signals necessary for glial cell growth arrest and differentiation are being studied. As a longterm goal, the axonal signals that trigger myelination by oligodendrocyte and Schwann cells will be approached by a combination of molecular and cellular approaches.



Academic office

435 East 30th Street, Science Building 11-05

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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PhD from University of California, Los Angeles

Thomasen, Pernille Bogetofte; Salasova, Alena; Kjaer-Sorensen, Kasper; Woloszczuková, Lucie; Lavický, Josef; Login, Hande; Tranberg-Jensen, Jeppe; Almeida, Sergio; Beel, Sander; Kavková, Michaela; Qvist, Per; Kjolby, Mads; Ovesen, Peter Lund; Nolte, Stella; Vestergaard, Benedicte; Udrea, Andreea-Cornelia; Nejsum, Lene Niemann; Chao, Moses V; Van Damme, Philip; Krivanek, Jan; Dasen, Jeremy; Oxvig, Claus; Nykjaer, Anders

Cell reports. 2023 Nov 28; 42(11):113333

Selles, Maria Clara; Fortuna, Juliana T S; de Faria, Yasmin P R; Siqueira, Luciana Domett; Lima-Filho, Ricardo; Longo, Beatriz M; Froemke, Robert C; Chao, Moses V; Ferreira, Sergio T

iScience. 2023 Apr 21; 26(4):106545

Hu, Hui-Lan; Khatri, Latika; Santacruz, Marilyn; Church, Emily; Moore, Christopher; Huang, Tony T; Chao, Moses V

Frontiers in molecular neuroscience. 2023 Jul; 16:1179209

Palumbo, Anna; Aluru, Viswanath; Battaglia, Jessica; Geller, Daniel; Turry, Alan; Ross, Marc; Cristian, Adrian; Balagula, Caitlin; Ogedegbe, Gbenga; Khatri, Latika; Chao, Moses V; Froemke, Robert C; Urbanek, Jacek K; Raghavan, Preeti

American journal of physical medicine & rehabilitation. 2022 Oct 01; 101(10):937-946

Bastioli, Guendalina; Arnold, Jennifer C; Mancini, Maria; Mar, Adam C; Gamallo-Lana, Begoña; Saadipour, Khalil; Chao, Moses V; Rice, Margaret E

Journal of neuroscience. 2022 06 08; 42(23):4725-4736

Hikima, Takuya; Witkovsky, Paul; Khatri, Latika; Chao, Moses V; Rice, Margaret E

Journal of neuroscience. 2022 May 11; 42(19):3919-3930

Mitre, Mariela; Saadipour, Khalil; Williams, Kevin; Khatri, Latika; Froemke, Robert C; Chao, Moses V

Frontiers in molecular neuroscience. 2022 Jun; 15:891537

Hu, Hui-Lan; Srinivas, Kalanghad P; Wang, Shuoshuo; Chao, Moses V; Lionnet, Timothee; Mohr, Ian; Wilson, Angus C; Depledge, Daniel P; Huang, Tony T

EMBO reports. 2021 Nov 29; e53543