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Nathaniel R. Landau

Nathaniel R. Landau, PhD

Professor, Department of Microbiology

HIV virion infectivity factor (VIF), HIV viral protein R (VPR), HIV accessory proteins, resistance to HIV infection, immunology, microbiology

Mammalian cells resist virus infections through the collection of mechanisms termed innate or intrinsic immunity. One such mechanism consists of a family of cytidine deaminases termed APOBEC3. These enzymes serve as mutators that destroy the genetic material of viruses such as HIV. HIV encodes a protein of its own, termed virion infectivity factor (Vif), that binds to APOBEC3 causing its degradation. We have focused on the mechanism by which APOBEC3 and Vif function and the species specificity of the interaction. We are also developing methods to identify small molecule inhibitors that disrupt the interaction. HIV encodes a second protein, viral protein R (VPR), that is involved in inducing the degradation of several host cell proteins and that may be a second means by which HIV counteracts intrinsic immunity. Vpr binds to a chromatin-associated E3 ubiquitin ligase consisting of DDB1/CUL4A/ROC1 through the DDB1 Cullin associated factor 1 (DCAF1). The complex degrades several host proteins. We are investigating the role of this complex in HIV replication and pathogenesis and how the Vpr controls affects its function.



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New York, NY 10016

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Professor, Department of Microbiology

PhD from Massachusetts Institute of Technology

Fellowship, University of California, San Francisco, Cancer Research

Fellowship, Massachusetts Institute of Technology

Vanwalscappel, Bénédicte; Tada, Takuya; Landau, Nathaniel R

Virology. 2018 09; 522:199-208

Jáuregui, Paula; Landau, Nathaniel R

Scientific reports. 2018 Mar 07; 8(1):4153

Interferon epsilon protects primary macrophages against HIV infection [Meeting Abstract]

chang, Theresa Li-Yun; Tasker, Carley; Subbian, Selvakumar; Gao, Pan; Couret, Jennifer; Levin, Carly; Ghanny, Saleena; Soteropoulos, Patricia; Zhao, Xilin; Landau, Nathaniel; Lu, Wuyuan

Journal of immunology (1950). 2017 MAY 1; 198:?-?

Bloch, Nicolin; Glasker, Sabine; Sitaram, Poojitha; Hofmann, Henning; Shepard, Caitlin N; Schultz, Megan L; Kim, Baek; Landau, Nathaniel R

Journal of biological chemistry. 2017 01 20; 292(3):1068-1080

Tam, Kayan; Schultz, Megan; Reyes-Robles, Tamara; Vanwalscappel, Benedicte; Horton, Joshua; Alonzo, Francis 3rd; Wu, Beili; Landau, Nathaniel R; Torres, Victor J

MBio. 2016 12 13; 7(6):

Tasker, Carley; Subbian, Selvakumar; Gao, Pan; Couret, Jennifer; Levine, Carly; Ghanny, Saleena; Soteropoulos, Patricia; Zhao, Xilin; Landau, Nathaniel; Lu, Wuyuan; Chang, Theresa L

JCI insight. 2016 12 08; 1(20):e88255

Hofmann, Henning; Vanwalscappel, Benedicte; Bloch, Nicolin; Landau, Nathaniel R

Retrovirology. 2016 Dec 01; 13(1):83

Simon, Viviana; Bloch, Nicolin; Landau, Nathaniel R

Nature immunology. 2015 Jun; 16(6):546-53