Nathaniel R. Landau

Nathaniel R. Landau, PhD

Professor, Department of Microbiology

Keywords
HIV virion infectivity factor (VIF), HIV viral protein R (VPR), HIV accessory proteins, resistance to HIV infection, immunology, microbiology
Summary

Mammalian cells resist virus infections through the collection of mechanisms termed innate or intrinsic immunity. One such mechanism consists of a family of cytidine deaminases termed APOBEC3. These enzymes serve as mutators that destroy the genetic material of viruses such as HIV. HIV encodes a protein of its own, termed virion infectivity factor (Vif), that binds to APOBEC3 causing its degradation. We have focused on the mechanism by which APOBEC3 and Vif function and the species specificity of the interaction. We are also developing methods to identify small molecule inhibitors that disrupt the interaction. HIV encodes a second protein, viral protein R (VPR), that is involved in inducing the degradation of several host cell proteins and that may be a second means by which HIV counteracts intrinsic immunity. Vpr binds to a chromatin-associated E3 ubiquitin ligase consisting of DDB1/CUL4A/ROC1 through the DDB1 Cullin associated factor 1 (DCAF1). The complex degrades several host proteins. We are investigating the role of this complex in HIV replication and pathogenesis and how the Vpr controls affects its function.

Phone

212-263-9197

Academic office

522 First Avenue

New York, NY 10016

Lab Website
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Professor, Department of Microbiology

PhD from Massachusetts Institute of Technology

Fellowship, University of California, San Francisco, Cancer Research

Fellowship, Massachusetts Institute of Technology

Interferon epsilon protects primary macrophages against HIV infection [Meeting Abstract]

Chang, T L -Y; Tasker, C; Subbian, S; Gao, P; Couret, J; Levin, C; Ghanny, S; Soteropoulos, P; Zhao, X; Landau, N; Lu, W

Journal of immunology (1950). 2017 May; Conference:(104th):

Tam, Kayan; Schultz, Megan; Reyes-Robles, Tamara; Vanwalscappel, Benedicte; Horton, Joshua; Alonzo, Francis 3rd; Wu, Beili; Landau, Nathaniel R; Torres, Victor J

MBio. 2016 Dec 13; 7(6):?-?

Tasker, Carley; Subbian, Selvakumar; Gao, Pan; Couret, Jennifer; Levine, Carly; Ghanny, Saleena; Soteropoulos, Patricia; Zhao, Xilin; Landau, Nathaniel; Lu, Wuyuan; Chang, Theresa L

JCI insight. 2016 Dec 8; 1(20):e88255-e88255e88255

Bloch, Nicolin; Glasker, Sabine; Sitaram, Poojitha; Hofmann, Henning; Shepard, Caitlin N; Schultz, Megan L; Kim, Baek; Landau, Nathaniel R

Journal of biological chemistry. 2016 Dec 5; 292(3):1068-1080

Hofmann, Henning; Vanwalscappel, Benedicte; Bloch, Nicolin; Landau, Nathaniel R

Retrovirology. 2016 Dec 01; 13(1):83-83

Simon, Viviana; Bloch, Nicolin; Landau, Nathaniel R

Nature immunology. 2015 Jun; 16(6):546-553

Jauregui, Paula; Logue, Eric C; Schultz, Megan L; Fung, Stephanie; Landau, Nathaniel R

Journal of virology. 2015 May; 89(10):5701-5713

Norton, T D; Miller, E A; Bhardwaj, N; Landau, N R

Gene therapy. 2015 Mar; 22(3):227-236