Nicholas J. Cowan

Nicholas J. Cowan, PhD

Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
protein folding in the eukaryotic cytosol
Summary

The final stage in the flow of information from encoded DNA to expressed proteins is the folding of each protein into its correct three-dimensional structure. In principle, such folding reactions can occur spontaneously because all the necessary information required to determine proper folding is contained within the primary amino acid sequence. However, under physiological conditions, constraints of temperature and the tendency of unfolded proteins to aggregate are such that many proteins must undergo facilitated folding via interaction with one or more protein complexes termed chaperonins. We are concerned with the mechanism whereby proteins in the eukaryotic cytosol, such as actin and tubulin, are folded via interaction with the cytoplasmic chaperonin, a heteromeric double toroid that provides a sequestered environment in which the unscrambling of aberrantly folded target proteins can occur. We are studying the nature of target proteins that interact with the chaperonin, the function of various cofactors that modulate the folding reaction, and the role of ATP hydrolysis in chaperonin-mediated folding.

Phone

212-263-5809

Fax

212-263-8166

Academic office

550 First Avenue, Medical Science Bldg.

3, 315

New York, NY 10016

Is this your profile?
These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
Loading...

Professor, Department of Biochemistry and Molecular Pharmacology

PhD from University of Oxford

Breuss, Martin W; Nguyen, Thai; Srivatsan, Anjana; Leca, Ines; Tian, Guoling; Fritz, Tanja; Hansen, Andi H; Musaev, Damir; McEvoy-Venneri, Jennifer; James, Kiely N; Rosti, Rasim O; Scott, Eric; Tan, Uner; Kolodner, Richard D; Cowan, Nicholas J; Keays, David A; Gleeson, Joseph G

Human molecular genetics. 2017 Jan 15; 26(2):258-269

Edvardson, Shimon; Tian, Guoling; Cullen, Hayley; Vanyai, Hannah; Ngo, Linh; Bhat, Saiuj; Aran, Adi; Daana, Muhannad; Da'amseh, Naderah; Abu-Libdeh, Bassam; Cowan, Nicholas J; Heng, Julian Ik-Tsen; Elpeleg, Orly

Human molecular genetics. 2016 Nov 01; 25(21):4635-4648

Tian, Guoling; Cristancho, Ana G; Dubbs, Holly A; Liu, Grant T; Cowan, Nicholas J; Goldberg, Ethan M

Molecular genetics & genomic medicine. 2016 Nov; 4:599-603

Feng, Ruizhi; Yan, Zheng; Li, Bin; Yu, Min; Sang, Qing; Tian, Guoling; Xu, Yao; Chen, Biaobang; Qu, Ronggui; Sun, Zhaogui; Sun, Xiaoxi; Jin, Li; He, Lin; Kuang, Yanping; Cowan, Nicholas J; Wang, Lei

Journal of medical genetics. 2016 Oct; 53(10):662-671

Feng, Ruizhi; Sang, Qing; Kuang, Yanping; Sun, Xiaoxi; Yan, Zheng; Zhang, Shaozhen; Shi, Juanzi; Tian, Guoling; Luchniak, Anna; Fukuda, Yusuke; Li, Bin; Yu, Min; Chen, Junling; Xu, Yao; Guo, Luo; Qu, Ronggui; Wang, Xueqian; Sun, Zhaogui; Liu, Miao; Shi, Huijuan; Wang, Hongyan; Feng, Yi; Shao, Ruijin; Chai, Renjie; Li, Qiaoli; Xing, Qinghe; Zhang, Rui; Nogales, Eva; Jin, Li; He, Lin; Gupta, Mohan L Jr; Cowan, Nicholas J; Wang, Lei

New England journal of medicine. 2016 Jan 21; 374(3):223-232

Isrie, Mala; Breuss, Martin; Tian, Guoling; Hansen, Andi Harley; Cristofoli, Francesca; Morandell, Jasmin; Kupchinsky, Zachari A; Sifrim, Alejandro; Rodriguez-Rodriguez, Celia Maria; Dapena, Elena Porta; Doonanco, Kurston; Leonard, Norma; Tinsa, Faten; Moortgat, Stephanie; Ulucan, Hakan; Koparir, Erkan; Karaca, Ender; Katsanis, Nicholas; Marton, Valeria; Vermeesch, Joris Robert; Davis, Erica E; Cowan, Nicholas J; Keays, David Anthony; Van Esch, Hilde

American journal of human genetics. 2015 Dec 03; 97(6):790-800

Poirier, Karine; Lebrun, Nicolas; Broix, Loic; Tian, Guoling; Saillour, Yoann; Boscheron, Cecile; Parrini, Elena; Valence, Stephanie; Pierre, Benjamin Saint; Oger, Madison; Lacombe, Didier; Genevieve, David; Fontana, Elena; Darra, Franscesca; Cances, Claude; Barth, Magalie; Bonneau, Dominique; Bernadina, Bernardo Dalla; N'guyen, Sylvie; Gitiaux, Cyril; Parent, Philippe; des Portes, Vincent; Pedespan, Jean Michel; Legrez, Victoire; Castelnau-Ptakine, Laetitia; Nitschke, Patrick; Hieu, Thierry; Masson, Cecile; Zelenika, Diana; Andrieux, Annie; Francis, Fiona; Guerrini, Renzo; Cowan, Nicholas J; Bahi-Buisson, Nadia; Chelly, Jamel

Nature genetics. 2013 Jun; 45(6):639-647

Tian, Guoling; Cowan, Nicholas J

Methods in cell biology. 2013; 115:155-171