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Nicholas J. Cowan

Nicholas J. Cowan, PhD

Professor, Department of Biochemistry and Molecular Pharmacology

protein folding in the eukaryotic cytosol

The final stage in the flow of information from encoded DNA to expressed proteins is the folding of each protein into its correct three-dimensional structure. In principle, such folding reactions can occur spontaneously because all the necessary information required to determine proper folding is contained within the primary amino acid sequence. However, under physiological conditions, constraints of temperature and the tendency of unfolded proteins to aggregate are such that many proteins must undergo facilitated folding via interaction with one or more protein complexes termed chaperonins. We are concerned with the mechanism whereby proteins in the eukaryotic cytosol, such as actin and tubulin, are folded via interaction with the cytoplasmic chaperonin, a heteromeric double toroid that provides a sequestered environment in which the unscrambling of aberrantly folded target proteins can occur. We are studying the nature of target proteins that interact with the chaperonin, the function of various cofactors that modulate the folding reaction, and the role of ATP hydrolysis in chaperonin-mediated folding.





Academic office

550 First Avenue, Medical Science Bldg.

3, 315

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication

Professor, Department of Biochemistry and Molecular Pharmacology

PhD from University of Oxford

Tripathy, Ratna; Leca, Ines; van Dijk, Tessa; Weiss, Janneke; van Bon, Bregje W; Sergaki, Maria Christina; Gstrein, Thomas; Breuss, Martin; Tian, Guoling; Bahi-Buisson, Nadia; Paciorkowski, Alexander R; Pagnamenta, Alistair T; Wenninger-Weinzierl, Andrea; Martinez-Reza, Maria Fernanda; Landler, Lukas; Lise, Stefano; Taylor, Jenny C; Terrone, Gaetano; Vitiello, Giuseppina; Del Giudice, Ennio; Brunetti-Pierri, Nicola; D'Amico, Alessandra; Reymond, Alexandre; Voisin, Norine; Bernstein, Jonathan A; Farrelly, Ellyn; Kini, Usha; Leonard, Thomas A; Valence, Stéphanie; Burglen, Lydie; Armstrong, Linlea; Hiatt, Susan M; Cooper, Gregory M; Aldinger, Kimberly A; Dobyns, William B; Mirzaa, Ghayda; Pierson, Tyler Mark; Baas, Frank; Chelly, Jamel; Cowan, Nicholas J; Keays, David Anthony

Neuron. 2018 Dec 19; 100(6):1354-1368.e5


Cullen, Hayley D.; Edvardson, Shimon; Tian, Guoling; Vanyai, Hannah; Ngo, Linh; Bhat, Saiuj; Aran, Adi; Daana, Muhannad; Da'amseh, Naderah; Abu-Libdeh, Bassam; Elpeleg, Orly; Cowan, Nicholas J.; Heng, Julian Ik-Tsen

Journal of gene medicine. 2018 JAN; 20:?-?

Lewis, Sally A.; Cowan, Nicholas J.

Microtubule Proteins. [S.l. : s.n.], 2018. p.37-66. (3856762)

Luscan, Romain; Mechaussier, Sabrina; Paul, Antoine; Tian, Guoling; Gérard, Xavier; Defoort-Dellhemmes, Sabine; Loundon, Natalie; Audo, Isabelle; Bonnin, Sophie; LeGargasson, Jean-François; Dumont, Julien; Goudin, Nicolas; Garfa-Traoré, Meriem; Bras, Marc; Pouliet, Aurore; Bessières, Bettina; Boddaert, Nathalie; Sahel, José-Alain; Lyonnet, Stanislas; Kaplan, Josseline; Cowan, Nicholas J; Rozet, Jean-Michel; Marlin, Sandrine; Perrault, Isabelle

American journal of human genetics. 2017 Dec 07; 101(6):1006-1012

Breuss, Martin W; Nguyen, Thai; Srivatsan, Anjana; Leca, Ines; Tian, Guoling; Fritz, Tanja; Hansen, Andi H; Musaev, Damir; McEvoy-Venneri, Jennifer; James, Kiely N; Rosti, Rasim O; Scott, Eric; Tan, Uner; Kolodner, Richard D; Cowan, Nicholas J; Keays, David A; Gleeson, Joseph G

Human molecular genetics. 2017 01 15; 26(2):258-269

Edvardson, Shimon; Tian, Guoling; Cullen, Hayley; Vanyai, Hannah; Ngo, Linh; Bhat, Saiuj; Aran, Adi; Daana, Muhannad; Da'amseh, Naderah; Abu-Libdeh, Bassam; Cowan, Nicholas J; Heng, Julian Ik-Tsen; Elpeleg, Orly

Human molecular genetics. 2016 11 01; 25(21):4635-4648

Tian, Guoling; Cristancho, Ana G; Dubbs, Holly A; Liu, Grant T; Cowan, Nicholas J; Goldberg, Ethan M

Molecular genetics & genomic medicine. 2016 Nov; 4(6):599-603

Feng, Ruizhi; Yan, Zheng; Li, Bin; Yu, Min; Sang, Qing; Tian, Guoling; Xu, Yao; Chen, Biaobang; Qu, Ronggui; Sun, Zhaogui; Sun, Xiaoxi; Jin, Li; He, Lin; Kuang, Yanping; Cowan, Nicholas J; Wang, Lei

Journal of medical genetics. 2016 10; 53(10):662-71