Nigel W. Bunnett, PhD

Professor, Department of Neuroscience

Positions

Professor, Department of Neuroscience at NYU Grossman School of Medicine

Graduate Education

PhD from University of Cambridge

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Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia

Teng, Shavonne L; Latorre, Rocco; Bhansali, Divya; Lewis, Parker K; Pollard, Rachel E; Peach, Chloe J; Sokrat, Badr; Thanigai Arasu, Gokul Sriman; Chiu, Tracy; Duran, Paz; Jimenez-Vargas, Nestor N; Mocherniak, Abby; Bogyo, Matthew; Gaspari, Michael M; Vanner, Stephen J; Pinkerton, Nathalie M; W Leong, Kam; Schmidt, Brian L; Jensen, Dane D; Bunnett, Nigel W

Proceedings of the National Academy of Sciences of the United States of America. 2025 Oct 14; 122(41):e2412687122

Nanoparticle-mediated antagonism of sustained endosomal signaling of the calcitonin receptor-like receptor provides enhanced and persistent relief of oral cancer pain

Peach, Chloe J; Tu, Nguyen Huu; Lewis, Parker K; Pollard, Rachel E; Sokrat, Badr; Nicholson, Sam; Trevett, Kai; Barrett, Naomi; De Logu, Francesco; Zhu, Jiaqi; Latorre, Rocco; Teng, Shavonne; Therien, Michael J; Jensen, Dane D; Schmidt, Brian L; Bunnett, Nigel W; Pinkerton, Nathalie M

Biomaterials. 2025 Oct 01; 327:123757

Endophilin A1 and synaptojanin 1-dependent endocytosis of synaptic vesicles in nociceptive spinal circuits maintains postoperative and cancer pain

Pessano Fialho, Maria Fernanda; Thanigai Arasu, Gokul Sriman; Chen, Shen; Imlach, Wendy L; Bunnett, Nigel W; Tonello, Raquel

Pain. 2025 May 27;

Pain Signaling by GPCRs and RTKs

Schmidt, Brain L; De Logu, Francesco; Nassini, Romina; Geppetti, Pierangelo; Bunnett, Nigel W

Trends in pharmacological science. 2025 Apr; 46(4):372-385

A pH-sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation

Degro, Claudius E; Jiménez-Vargas, Nestor Nivardo; Guzman-Rodriguez, Mabel; Schincariol, Hailey; Tsang, Quentin; Reed, David E; Lomax, Alan E; Bunnett, Nigel W; Stein, Christoph; Vanner, Stephen J

British journal of pharmacology. 2025 Feb; 182(3):581-595

TRPV4 activation in Schwann cells mediates mechanically induced pain of oral cancer

Mulpuri, Yatendra; Tu, Nguyen H; Inoue, Kenji; Harden, Grace; Nicholson, Samuel J; Seenauth, Anisa; Huang, Yan; Escobar, Keylin G; Moayedi, Yalda; Bunnett, Nigel W; Albertson, Donna G; Schmidt, Brian L

Frontiers in pain research (Lausanne, Switzerland). 2025 Mar; 6:1532885

Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models

Peach, Chloe J; Tonello, Raquel; Damo, Elisa; Gomez, Kimberly; Calderon-Rivera, Aida; Bruni, Renato; Bansia, Harsh; Maile, Laura; Manu, Ana-Maria; Hahn, Hyunggu; Thomsen, Alex Rb; Schmidt, Brian L; Davidson, Steve; des Georges, Amedee; Khanna, Rajesh; Bunnett, Nigel W

Journal of clinical investigation. 2024 Nov 26; 135(4):

N-terminomics profiling of naïve and inflamed murine colon reveals proteolytic signatures of legumain

Ziegler, Alexander R; Anderson, Bethany M; Latorre, Rocco; McQuade, Rachel M; Dufour, Antoine; Schmidt, Brian L; Bunnett, Nigel W; Scott, Nichollas E; Edgington-Mitchell, Laura E

Journal of cellular physiology. 2024 Oct 11; e31466

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