Nigel W. Bunnett, PhD

Professor, Department of Neuroscience and Physiology

Positions

Professor, Department of Neuroscience and Physiology at NYU Grossman School of Medicine

Graduate Education

PhD from Cambridge University

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Pain Signaling by GPCRs and RTKs

Schmidt, Brain L; De Logu, Francesco; Nassini, Romina; Geppetti, Pierangelo; Bunnett, Nigel W

Trends in pharmacological sciences. 2025 Mar 07;

A pH-sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation

Degro, Claudius E; Jiménez-Vargas, Nestor Nivardo; Guzman-Rodriguez, Mabel; Schincariol, Hailey; Tsang, Quentin; Reed, David E; Lomax, Alan E; Bunnett, Nigel W; Stein, Christoph; Vanner, Stephen J

British journal of pharmacology. 2025 Feb; 182(3):581-595

TRPV4 activation in Schwann cells mediates mechanically induced pain of oral cancer

Mulpuri, Yatendra; Tu, Nguyen H; Inoue, Kenji; Harden, Grace; Nicholson, Samuel J; Seenauth, Anisa; Huang, Yan; Escobar, Keylin G; Moayedi, Yalda; Bunnett, Nigel W; Albertson, Donna G; Schmidt, Brian L

Frontiers in pain research (Lausanne, Switzerland). 2025 Mar; 6:1532885

Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models

Peach, Chloe J; Tonello, Raquel; Damo, Elisa; Gomez, Kimberly; Calderon-Rivera, Aida; Bruni, Renato; Bansia, Harsh; Maile, Laura; Manu, Ana-Maria; Hahn, Hyunggu; Thomsen, Alex Rb; Schmidt, Brian L; Davidson, Steve; des Georges, Amedee; Khanna, Rajesh; Bunnett, Nigel W

Journal of clinical investigation. 2024 Nov 26; 135(4):

N-terminomics profiling of naïve and inflamed murine colon reveals proteolytic signatures of legumain

Ziegler, Alexander R; Anderson, Bethany M; Latorre, Rocco; McQuade, Rachel M; Dufour, Antoine; Schmidt, Brian L; Bunnett, Nigel W; Scott, Nichollas E; Edgington-Mitchell, Laura E

Journal of cellular physiology. 2024 Oct 11; e31466

PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451

Bhansali, Divya; Tu, Nguyen H; Inoue, Kenji; Teng, Shavonne; Li, Tianyu; Tran, Hung D; Kim, Dong H; Dong, Jessy; Peach, Chloe J; Sokrat, Badr; Jensen, Dane D; Dolan, John C; Yamano, Seiichi; Robinson, Valeria Mezzano; Bunnett, Nigel W; Albertson, Donna G; Leong, Kam W; Schmidt, Brian L

Biomaterials. 2024 Oct 02; 314:122874

Protease-Induced Excitation of Dorsal Root Ganglion Neurons in Response to Acute Perturbation of the Gut Microbiota Is Associated With Visceral and Somatic Hypersensitivity

Baker, Corey C; Sessenwein, Jessica L; Wood, Hannah M; Yu, Yang; Tsang, Quentin; Alward, Taylor A; Jimenez Vargas, Nestor N; Omar, Amal Abu; McDonnel, Abby; Segal, Julia P; Sjaarda, Calvin P; Bunnett, Nigel W; Schmidt, Brian L; Caminero, Alberto; Boev, Nadejda; Bannerman, Courtney A; Ghasemlou, Nader; Sheth, Prameet M; Vanner, Stephen J; Reed, David E; Lomax, Alan E

Cellular & molecular gastroenterology & hepatology. 2024 Mar 16; 18(4):101334

Neuropilin-1 is essential for vascular endothelial growth factor A-mediated increase of sensory neuron activity and development of pain-like behaviors

Gomez, Kimberly; Duran, Paz; Tonello, Raquel; Allen, Heather N; Boinon, Lisa; Calderon-Rivera, Aida; Loya-López, Santiago; Nelson, Tyler S; Ran, Dongzhi; Moutal, Aubin; Bunnett, Nigel W; Khanna, Rajesh

Pain. 2023 Dec 01; 164(12):2696-2710

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