Nigel W. Bunnett, PhD

Professor, Department of Neuroscience

Positions

Professor, Department of Neuroscience at NYU Grossman School of Medicine

Graduate Education

PhD from University of Cambridge

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EGFR activation sensitizes trigeminal NMDA receptors to promote pain and morphine analgesic tolerance in oral cancer

Liu, Naijiang; Shi, Xiaojie; Chen, Shao-Rui; Chen, Hong; Santi, Maria Daniela; Dong, Minh Phuong; Fialho, Maria Fernanda Pessano; Xie, Tongxin; Gleber-Netto, Frederico; Latorre, Rocco; Bunnett, Nigel W; Viet, Chi T; Amit, Moran; Pan, Hui-Lin; Ye, Yi

Science signaling. 2026 Jan 27; 19(922):eadt3026

Nanoparticle-mediated antagonism of sustained endosomal signaling of the calcitonin receptor-like receptor provides enhanced and persistent relief of oral cancer pain

Peach, Chloe J.; Tu, Nguyen Huu; Lewis, Parker K.; Pollard, Rachel E.; Sokrat, Badr; Nicholson, Sam; Trevett, Kai; Barrett, Naomi; De Logu, Francesco; Zhu, Jiaqi; Latorre, Rocco; Teng, Shavonne; Therien, Michael J.; Jensen, Dane D.; Schmidt, Brian L.; Bunnett, Nigel W.; Pinkerton, Nathalie M.

Biomaterials. 2026; 327:

Probing the activity of cysteine cathepsins in inflammatory bowel diseases

Anderson, Bethany M; Ziegler, Alexander R; Campden, Rhiannon I; Wu, Hongyi; Xu, Bangyan; McQuade, Rachel M; Carbone, Simona E; Poole, Daniel P; Lomax, Alan E; Reed, David E; Vanner, Stephen J; Yates, Robin M; Bunnett, Nigel W; Edgington-Mitchell, Laura E

Scientific reports. 2025 Dec 23; 16(1):2739

Endophilin A1 and synaptojanin 1-dependent endocytosis of synaptic vesicles in nociceptive spinal circuits maintains postoperative and cancer pain

Pessano Fialho, Maria Fernanda; Thanigai Arasu, Gokul Sriman; Chen, Shen; Imlach, Wendy L; Bunnett, Nigel W; Tonello, Raquel

Pain. 2025 Nov 01; 166(11):e563-e576

Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia

Teng, Shavonne L; Latorre, Rocco; Bhansali, Divya; Lewis, Parker K; Pollard, Rachel E; Peach, Chloe J; Sokrat, Badr; Thanigai Arasu, Gokul Sriman; Chiu, Tracy; Duran, Paz; Jimenez-Vargas, Nestor N; Mocherniak, Abby; Bogyo, Matthew; Gaspari, Michael M; Vanner, Stephen J; Pinkerton, Nathalie M; W Leong, Kam; Schmidt, Brian L; Jensen, Dane D; Bunnett, Nigel W

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2025 Oct 14; 122(41):e2412687122

A Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation

Lakemeyer, Markus; Latorre, Rocco; Blazkova, Kristyna; Wood, Hannah M; Jensen, Dane D; Shakil, Nayab; Thomas, Scott C; Saxena, Deepak; Mulpuri, Yatendra; Poolman, David; Duran, Paz; Keller, Laura J; Reed, David E; Schmidt, Brian L; Jiménez-Vargas, Néstor N; Xu, Fangxi; Lomax, Alan E; Bunnett, Nigel W; Bogyo, Matthew

Cell host & microbe. 2025 Oct 08; 33(10):1686-1702.e11

Nanoparticle-mediated antagonism of sustained endosomal signaling of the calcitonin receptor-like receptor provides enhanced and persistent relief of oral cancer pain

Peach, Chloe J; Tu, Nguyen Huu; Lewis, Parker K; Pollard, Rachel E; Sokrat, Badr; Nicholson, Sam; Trevett, Kai; Barrett, Naomi; De Logu, Francesco; Zhu, Jiaqi; Latorre, Rocco; Teng, Shavonne; Therien, Michael J; Jensen, Dane D; Schmidt, Brian L; Bunnett, Nigel W; Pinkerton, Nathalie M

Biomaterials. 2025 Oct 01; 327:123757

Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation

Nassini, Romina; Landini, Lorenzo; Marini, Matilde; Chieca, Martina; Souza Monteiro de Araújo, Daniel; Montini, Marco; Pensieri, Pasquale; Abruzzese, Vittorio Donato; De Siena, Gaetano; Zhang, Jin; Bellantoni, Elisa; De Giorgi, Vincenzo; Romitelli, Antonia; Brancolini, Giulia; Tonello, Raquel; Peach, Chloe J; Mastricci, Alessandra; Scuffi, Irene; Tesi, Martina; Jensen, Dane D; Schmidt, Brian L; Bunnett, Nigel W; De Logu, Francesco; Geppetti, Pierangelo

Nature communications. 2025 Sep 25; 16(1):8262

See All Publications (393)