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Orna Issler, PhD

Neuroscience Institute

Assistant Professor, Department of Anesthesiology, Perioperative Care, and Pain Medicine

Assistant Professor, Department of Neuroscience and Physiology

Stress, Depression, non-coding RNA, lncRNA, sex differeces , Chronic pain

Until recently, non-coding RNAs were considered transcriptional noise or even ‘junk.’ Advances in transcriptomic profiling revolutionized our appreciation of the abundance and prevalence of ncRNA transcripts in humans. Evidence suggests that the expression of ncRNA is enriched in the brain, yet our understanding of how these genes regulate normal and pathological brain functions is still in its infancy.

We discovered a critical role of ncRNAs in regulating mood linking both microRNAs and long non-coding RNAs to increased susceptibility or resilience to depression. While our knowledge is expanding, it is far from complete. Particularly, there is a great need for identifying novel diagnostic and therapeutic targets and delivery approaches for depression and chronic pain, leading causes of disability worldwide.

We utilize an integrated approach, spanning from mouse to human, to study the role of non-coding RNAs in neuroscience. Toward that end, our group will perform:

  • Basic Research to answer the question: How do non-coding RNAs contribute to the regulation of stress and pain?
  • Translational Research Developing novel ncRNA-based diagnostic and therapeutic tools for stress and pain disorders.
Academic office

Science Building, 435 E 30th St,

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

PhD from Weizmann Institute of Science

Icahn School of Medicine at Mount Sinai , Eric Nestler

Issler, Orna; van der Zee, Yentl Y; Ramakrishnan, Aarthi; Xia, Sunhui; Zinsmaier, Alexander K; Tan, Chunfeng; Li, Wei; Browne, Caleb J; Walker, Deena M; Salery, Marine; Torres-Berrío, Angélica; Futamura, Rita; Duffy, Julia E; Labonte, Benoit; Girgenti, Matthew J; Tamminga, Carol A; Dupree, Jeffrey L; Dong, Yan; Murrough, James W; Shen, Li; Nestler, Eric J

Science advances. 2022 Dec 02; 8(48):eabn9494

van der Zee, Yentl Y; Eijssen, Lars M T; Mews, Philipp; Ramakrishnan, Aarthi; Alvarez, Kelvin; Lardner, Casey K; Cates, Hannah M; Walker, Deena M; Torres-Berrío, Angélica; Browne, Caleb J; Cunningham, Ashley; Cathomas, Flurin; Kronman, Hope; Parise, Eric M; de Nijs, Laurence; Shen, Li; Murrough, James W; Rutten, Bart P F; Nestler, Eric J; Issler, Orna

Molecular psychiatry. 2022 Nov; 27(11):4536-4549

Issler, Orna; van der Zee, Yentl Y; Ramakrishnan, Aarthi; Wang, Junshi; Tan, Chunfeng; Loh, Yong-Hwee E; Purushothaman, Immanuel; Walker, Deena M; Lorsch, Zachary S; Hamilton, Peter J; Peña, Catherine J; Flaherty, Erin; Hartley, Brigham J; Torres-Berrío, Angélica; Parise, Eric M; Kronman, Hope; Duffy, Julia E; Estill, Molly S; Calipari, Erin S; Labonté, Benoit; Neve, Rachael L; Tamminga, Carol A; Brennand, Kristen J; Dong, Yan; Shen, Li; Nestler, Eric J

Neuron. 2020 Jun 17; 106(6):912-926.e5

Issler, Orna; Haramati, Sharon; Paul, Evan D; Maeno, Hiroshi; Navon, Inbal; Zwang, Rayya; Gil, Shosh; Mayberg, Helen S; Dunlop, Boadie W; Menke, Andreas; Awatramani, Rajeshwar; Binder, Elisabeth B; Deneris, Evan S; Lowry, Christopher A; Chen, Alon

Neuron. 2014 Jul 16; 83(2):344-360

Issler, Orna; Chen, Alon

Nature reviews. Neuroscience. 2015 Apr; 16(4):201-12

van der Zee, Yentl Y; Lardner, Casey K; Parise, Eric M; Mews, Philipp; Ramakrishnan, Aarthi; Patel, Vishwendra; Teague, Collin D; Salery, Marine; Walker, Deena M; Browne, Caleb J; Labonté, Benoit; Parise, Lyonna F; Kronman, Hope; Penã, Catherine J; Torres-Berrío, Angélica; Duffy, Julia E; de Nijs, Laurence; Eijssen, Lars M T; Shen, Li; Rutten, Bart; Issler, Orna; Nestler, Eric J

Biological psychiatry. 2022 Jan 01; 91(1):81-91

Issler, Orna; Lorsch, Zachary S.; Nestler, Eric J.


Torres-Berrío, Angélica; Estill, Molly; Ramakrishnan, Aarthi; Kronman, Hope; Patel, Vishwendra; Minier-Toribio, Angélica; Issler, Orna; Browne, Caleb J; Parise, Eric M; van der Zee, Yentl; Walker, Deena; Martínez-Rivera, Freddyson J; Lardner, Casey K; Cuttoli, Romain Durand-de; Russo, Scott J; Shen, Li; Sidoli, Simone; Nestler, Eric J : the preprint server for biology. 2023 May 08;