Assistant Professor, Department of Anesthesiology, Perioperative Care, and Pain Medicine
Assistant Professor, Department of Neuroscience and Physiology
Until recently, non-coding RNAs were considered transcriptional noise or even ‘junk.’ Advances in transcriptomic profiling revolutionized our appreciation of the abundance and prevalence of ncRNA transcripts in humans. Evidence suggests that the expression of ncRNA is enriched in the brain, yet our understanding of how these genes regulate normal and pathological brain functions is still in its infancy.
We discovered a critical role of ncRNAs in regulating mood linking both microRNAs and long non-coding RNAs to increased susceptibility or resilience to depression. While our knowledge is expanding, it is far from complete. Particularly, there is a great need for identifying novel diagnostic and therapeutic targets and delivery approaches for depression and chronic pain, leading causes of disability worldwide.
We utilize an integrated approach, spanning from mouse to human, to study the role of non-coding RNAs in neuroscience. Toward that end, our group will perform:
Science Building, 435 E 30th St,
New York, NY 10016
PhD from Weizmann Institute of Science
Icahn School of Medicine at Mount Sinai , Eric Nestler
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