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Pau Castel

Pau Castel, PhD

Assistant Professor, Department of Biochemistry and Molecular Pharmacology

Summary

The Castel laboratory is interested in understanding the molecular mechanisms underlying oncoprotein-mediated transformation. Our laboratory uses biochemical, cell signaling, mouse modeling, and pharmacological approaches to elucidate the functions and regulation of different oncoproteins in cancer and congenital disorders. We are particularly interested in the RAS family of GTPases, which are involved in mitogenic signaling and are notorious drivers of cancer and neurodevelopmental syndromes.

More specifically, the current projects in our laboratory include: 

1. Study of RAS protein effectors and their contribution to disease. 

2. Regulation of RAS signaling components by ubiquitination and proteasomal degradation. 

3. Development of cellular and mouse models that recapitulate RAS-driven diseases. 

Overall, our research program will provide novel mechanistic insights into the complex process of transformation and is aimed at identifying and developing novel therapeutic strategies for cancer and congenital disorders.      

Academic office

450 East 29th Street, ACLS - East Tower

8th floor, Room 828

New York, NY 10016

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PhD from University of Barcelona

University of California San Francisco , Frank McCormick Lab

Chen, Sisi; Vedula, Rahul S; Cuevas-Navarro, Antonio; Lu, Bin; Hogg, Simon J; Wang, Eric; Benbarche, Salima; Knorr, Katherine; Kim, Won Jun; Stanley, Robert F; Cho, Hana; Erickson, Caroline; Singer, Michael; Cui, Dan; Tittley, Steven; Durham, Benjamin H; Pavletich, Tatiana S; Fiala, Elise; Walsh, Michael F; Inoue, Daichi; Monette, Sebastien; Taylor, Justin; Rosen, Neal; McCormick, Frank; Lindsley, R Coleman; Castel, Pau; Abdel-Wahab, Omar

Cancer discovery. 2022 Oct 05; 12(10):2434-2453

Rodríguez-Muñoz, Laura; Lagares, Clàudia; González-Crespo, Sergio; Castel, Pau; Veraksa, Alexey; Jiménez, Gerardo

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2022 Aug 02; 119(31):e2123467119

Ladewig, Erik; Michelini, Flavia; Jhaveri, Komal; Castel, Pau; Carmona, Javier; Fairchild, Lauren; Zuniga, Adler G; Arruabarrena-Aristorena, Amaia; Cocco, Emiliano; Blawski, Ryan; Kittane, Srushti; Zhang, Yuhan; Sallaku, Mirna; Baldino, Laura; Hristidis, Vasilis; Chandarlapaty, Sarat; Abdel-Wahab, Omar; Leslie, Christina; Scaltriti, Maurizio; Toska, Eneda

Cancer research. 2022 Jun 15; 82(12):2269-2280

Kontaridis, Maria I; Roberts, Amy E; Schill, Lisa; Schoyer, Lisa; Stronach, Beth; Andelfinger, Gregor; Aoki, Yoko; Axelrad, Marni E; Bakker, Annette; Bennett, Anton M; Broniscer, Alberto; Castel, Pau; Chang, Caitlin A; Cyganek, Lukas; Das, Tirtha K; den Hertog, Jeroen; Galperin, Emilia; Garg, Shruti; Gelb, Bruce D; Gordon, Kristiana; Green, Tamar; Gripp, Karen W; Itkin, Maxim; Kiuru, Maija; Korf, Bruce R; Livingstone, Jeff R; López-Juárez, Alejandro; Magoulas, Pilar L; Mansour, Sahar; Milner, Theresa; Parker, Elisabeth; Pierpont, Elizabeth I; Plouffe, Kevin; Rauen, Katherine A; Shankar, Suma P; Smith, Shane B; Stevenson, David A; Tartaglia, Marco; Van, Richard; Wagner, Morgan E; Ware, Stephanie M; Zenker, Martin

American journal of medical genetics. Part A. 2022 Jun; 188(6):1915-1927

Cuevas-Navarro, Antonio; Rodriguez-Muñoz, Laura; Grego-Bessa, Joaquim; Cheng, Alice; Rauen, Katherine A; Urisman, Anatoly; McCormick, Frank; Jimenez, Gerardo; Castel, Pau

eLife. 2022 Apr 25; 11:

Monelli, Erika; Villacampa, Pilar; Zabala-Letona, Amaia; Martinez-Romero, Anabel; Llena, Judith; Beiroa, Daniel; Gouveia, Leonor; Chivite, Iñigo; Zagmutt, Sebastián; Gama-Perez, Pau; Osorio-Conles, Oscar; Muixi, Laia; Martinez-Gonzalez, Ainara; Castillo, Sandra D; Martín-Martín, Natalia; Castel, Pau; Valcarcel-Jimenez, Lorea; Garcia-Gonzalez, Irene; Villena, Josep A; Fernandez-Ruiz, Sonia; Serra, Dolors; Herrero, Laura; Benedito, Rui; Garcia-Roves, Pablo; Vidal, Josep; Cohen, Paul; Nogueiras, Rubén; Claret, Marc; Carracedo, Arkaitz; Graupera, Mariona

Nature metabolism. 2022 Mar; 4(3):327-343

Castel, Pau

Biochimica et biophysica acta. Molecular basis of disease. 2022 Feb 11; 1868(5):166366

Cuevas-Navarro, Antonio; Van, Richard; Cheng, Alice; Urisman, Anatoly; Castel, Pau; McCormick, Frank

Current biology. CB. 2021 Sep 13; 31(17):3915-3924.e9