Peng Lee, MD, PhD

Professor, Department of Pathology

Professor, Department of Urology

Keywords
cancer, Androgen receptor and its cofactors and target genes in prostate and breast cancer
Summary

The principal research focus of our group is to elucidate the molecular mechanism of hormonal (androgen and estrogen) receptors, their cofactors, and their target genes in the development of endocrine organs and malignancies, including breast and prostate cancers. In particular, we are interested in understanding the molecular mechanisms underlying the development of androgen-independent prostate cancer. A compelling element of our research is to understand how the expression and function of proteins in the stromal androgen receptor (AR) pathway influences the stromal-epithelial interactions, contributing to tumorigenesis. The long term goal of the lab is to apply these findings to clinically relevant issues; to identify prognostic or predictive biomarkers, and to discover novel therapeutic strategies for these cancers.

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Positions

Professor, Department of Pathology at NYU Grossman School of Medicine

Professor, Department of Urology at NYU Grossman School of Medicine

Graduate Education

PhD from State University of New York

MD from Peking University

Caregiver burden and its associated factors among family caregivers of persons with dementia in Shanghai, China: a cross-sectional study

Liu, Zhijian; Sun, Wenjing; Chen, Honglin; Zhuang, Jianhua; Wu, Bei; Xu, Hanzhang; Li, Peng; Chen, Xiaohan; Li, Juan; Yin, You

BMJ open. 2022 05 24; 12(5):e057817

Identification of novel biomarkers differentially expressed between African-American and Caucasian-American prostate cancer patients

Ye, Fei; Han, Xiaoxia; Shao, Yonzhao; Lo, Jingzhi; Zhang, Fengxia; Wang, Jinhua; Melamed, Jonathan; Deng, Fang-Ming; Sfanos, Karen S; De Marzo, Angelo; Ren, Guoping; Wang, Dongwen; Zhang, David; Lee, Peng

American journal of cancer research. 2022 Aug; 12(4):1660-1670

Effect of Serum Urate Lowering With Allopurinol on Blood Pressure in Young Adults: A Randomized, Controlled, Crossover Trial

Gaffo, Angelo L; Calhoun, David A; Rahn, Elizabeth J; Oparil, Suzanne; Li, Peng; Dudenbostel, Tanja; Feig, Daniel I; Redden, David T; Muntner, Paul; Foster, Phillip J; Biggers-Clark, Stephanie R; Mudano, Amy; Sattui, Sebastian E; Saddekni, Michael B; Bridges, S Louis; Saag, Kenneth G

Arthritis & rheumatology. 2021 08; 73(8):1514-1522

Metastasis and immune evasion from extracellular cGAMP hydrolysis

Li, Jun; Duran, Mercedes A; Dhanota, Ninjit; Chatila, Walid K; Bettigole, Sarah E; Kwon, John; Sriram, Roshan K; Humphries, Matthew Philip; Salto-Tellez, Manuel; James, Jacqueline A; Hanna, Matthew G; Melms, Johannes C; Vallabhaneni, Sreeram; Litchfield, Kevin; Usaite, Ieva; Biswas, Dhruva; Bareja, Rohan; Li, Hao Wei; Martin, Maria Laura; Dorsaint, Princesca; Cavallo, Julie-Ann; Li, Peng; Pauli, Chantal; Gottesdiener, Lee; DiPardo, Benjamin J; Hollmann, Travis J; Merghoub, Taha; Wen, Hannah Y; Reis-Filho, Jorge S; Riaz, Nadeem; Su, Shin-San Michael; Kalbasi, Anusha; Vasan, Neil; Powell, Simon N; Wolchok, Jedd D; Elemento, Olivier; Swanton, Charles; Shoushtari, Alexander N; Parkes, Eileen E; Izar, Benjamin; Bakhoum, Samuel F

Cancer discovery. 2021 May; 11(5):1212-1227

[Research progress on bone defect repair materials]

Cao, Guo-Ding; Pei, Yu-Qi; Liu, Jun; Li, Peng; Liu, Peng; Li, Xu-Sheng

Zhongguo gu shang = China journal of orthopaedics & traumatology. 2021 Apr 25; 34(4):382-8

Sex specific associations in genome wide association analysis of renal cell carcinoma

Laskar, Ruhina S; Muller, David C; Li, Peng; Machiela, Mitchell J; Ye, Yuanqing; Gaborieau, Valerie; Foll, Matthieu; Hofmann, Jonathan N; Colli, Leandro; Sampson, Joshua N; Wang, Zhaoming; Bacq-Daian, Delphine; Boland, Anne; Abedi-Ardekani, Behnoush; Durand, Geoffroy; Le Calvez-Kelm, Florence; Robinot, Nivonirina; Blanche, Helene; Prokhortchouk, Egor; Skryabin, Konstantin G; Burdett, Laurie; Yeager, Meredith; Radojevic-Skodric, Sanja; Savic, Slavisa; Foretova, Lenka; Holcatova, Ivana; Janout, Vladimir; Mates, Dana; Rascu, Stefan; Mukeria, Anush; Zaridze, David; Bencko, Vladimir; Cybulski, Cezary; Fabianova, Eleonora; Jinga, Viorel; Lissowska, Jolanta; Lubinski, Jan; Navratilova, Marie; Rudnai, Peter; ÅšwiÄ…tkowska, Beata; Benhamou, Simone; Cancel-Tassin, Geraldine; Cussenot, Olivier; Trichopoulou, Antonia; Riboli, Elio; Overvad, Kim; Panico, Salvatore; Ljungberg, Borje; Sitaram, Raviprakash T; Giles, Graham G; Milne, Roger L; Severi, Gianluca; Bruinsma, Fiona; Fletcher, Tony; Koppova, Kvetoslava; Larsson, Susanna C; Wolk, Alicja; Banks, Rosamonde E; Selby, Peter J; Easton, Douglas F; Pharoah, Paul; Andreotti, Gabriella; Beane Freeman, Laura E; Koutros, Stella; Albanes, Demetrius; Männistö, Satu; Weinstein, Stephanie; Clark, Peter E; Edwards, Todd L; Lipworth, Loren; Carol, Hallie; Freedman, Matthew L; Pomerantz, Mark M; Cho, Eunyoung; Kraft, Peter; Preston, Mark A; Wilson, Kathryn M; Michael Gaziano, J; Sesso, Howard D; Black, Amanda; Freedman, Neal D; Huang, Wen-Yi; Anema, John G; Kahnoski, Richard J; Lane, Brian R; Noyes, Sabrina L; Petillo, David; Teh, Bin Tean; Peters, Ulrike; White, Emily; Anderson, Garnet L; Johnson, Lisa; Luo, Juhua; Chow, Wong-Ho; Moore, Lee E; Choueiri, Toni K; Wood, Christopher; Johansson, Mattias; McKay, James D; Brown, Kevin M; Rothman, Nathaniel; Lathrop, Mark G; Deleuze, Jean-Francois; Wu, Xifeng; Brennan, Paul; Chanock, Stephen J; Purdue, Mark P; Scelo, Ghislaine

European journal of human genetics. 2019 Oct; 27(10):1589-1598

Effect of Preanalytic Variables on an Automated PTEN Immunohistochemistry Assay for Prostate Cancer

Guedes, Liana B; Morais, Carlos L; Fedor, Helen; Hicks, Jessica; Gurel, Bora; Melamed, Jonathan; Lee, Peng; Gopalan, Anuradha; Knudsen, Beatrice S; True, Lawrence D; Scher, Howard I; Fine, Samson W; Trock, Bruce J; De Marzo, Angelo M; Lotan, Tamara L

Archives of pathology & laboratory medicine. 2019 Mar; 143(3):338-348

Prostate-specific loss of UXT promotes cancer progression

Wang, Yu; Schafler, Eric D; Thomas, Phillip A; Ha, Susan; David, Gregory; Adney, Emily; Garabedian, Michael J; Lee, Peng; Logan, Susan K

Oncotarget. 2019 Jan 22; 10(7):707-716

See All Publications (215)