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Peng Lee, MD, PhD

Professor, Department of Pathology

Professor, Department of Urology

Keywords
cancer, Androgen receptor and its cofactors and target genes in prostate and breast cancer
Summary

The principal research focus of our group is to elucidate the molecular mechanism of hormonal (androgen and estrogen) receptors, their cofactors, and their target genes in the development of endocrine organs and malignancies, including breast and prostate cancers. In particular, we are interested in understanding the molecular mechanisms underlying the development of androgen-independent prostate cancer. A compelling element of our research is to understand how the expression and function of proteins in the stromal androgen receptor (AR) pathway influences the stromal-epithelial interactions, contributing to tumorigenesis. The long term goal of the lab is to apply these findings to clinically relevant issues; to identify prognostic or predictive biomarkers, and to discover novel therapeutic strategies for these cancers.

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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PhD from State University Of New York

MD from Peking University

Ye, Fei; Han, Xiaoxia; Shao, Yonzhao; Lo, Jingzhi; Zhang, Fengxia; Wang, Jinhua; Melamed, Jonathan; Deng, Fang-Ming; Sfanos, Karen S; De Marzo, Angelo; Ren, Guoping; Wang, Dongwen; Zhang, David; Lee, Peng

American journal of cancer research. 2022 Aug; 12(4):1660-1670

Gaffo, Angelo L; Calhoun, David A; Rahn, Elizabeth J; Oparil, Suzanne; Li, Peng; Dudenbostel, Tanja; Feig, Daniel I; Redden, David T; Muntner, Paul; Foster, Phillip J; Biggers-Clark, Stephanie R; Mudano, Amy; Sattui, Sebastian E; Saddekni, Michael B; Bridges, S Louis; Saag, Kenneth G

Arthritis & rheumatology. 2021 08; 73(8):1514-1522

Li, Jun; Duran, Mercedes A; Dhanota, Ninjit; Chatila, Walid K; Bettigole, Sarah E; Kwon, John; Sriram, Roshan K; Humphries, Matthew Philip; Salto-Tellez, Manuel; James, Jacqueline A; Hanna, Matthew G; Melms, Johannes C; Vallabhaneni, Sreeram; Litchfield, Kevin; Usaite, Ieva; Biswas, Dhruva; Bareja, Rohan; Li, Hao Wei; Martin, Maria Laura; Dorsaint, Princesca; Cavallo, Julie-Ann; Li, Peng; Pauli, Chantal; Gottesdiener, Lee; DiPardo, Benjamin J; Hollmann, Travis J; Merghoub, Taha; Wen, Hannah Y; Reis-Filho, Jorge S; Riaz, Nadeem; Su, Shin-San Michael; Kalbasi, Anusha; Vasan, Neil; Powell, Simon N; Wolchok, Jedd D; Elemento, Olivier; Swanton, Charles; Shoushtari, Alexander N; Parkes, Eileen E; Izar, Benjamin; Bakhoum, Samuel F

Cancer discovery. 2021 May; 11(5):1212-1227

Cao, Guo-Ding; Pei, Yu-Qi; Liu, Jun; Li, Peng; Liu, Peng; Li, Xu-Sheng

Zhongguo gu shang = China journal of orthopaedics & traumatology. 2021 Apr 25; 34(4):382-8

Laskar, Ruhina S; Muller, David C; Li, Peng; Machiela, Mitchell J; Ye, Yuanqing; Gaborieau, Valerie; Foll, Matthieu; Hofmann, Jonathan N; Colli, Leandro; Sampson, Joshua N; Wang, Zhaoming; Bacq-Daian, Delphine; Boland, Anne; Abedi-Ardekani, Behnoush; Durand, Geoffroy; Le Calvez-Kelm, Florence; Robinot, Nivonirina; Blanche, Helene; Prokhortchouk, Egor; Skryabin, Konstantin G; Burdett, Laurie; Yeager, Meredith; Radojevic-Skodric, Sanja; Savic, Slavisa; Foretova, Lenka; Holcatova, Ivana; Janout, Vladimir; Mates, Dana; Rascu, Stefan; Mukeria, Anush; Zaridze, David; Bencko, Vladimir; Cybulski, Cezary; Fabianova, Eleonora; Jinga, Viorel; Lissowska, Jolanta; Lubinski, Jan; Navratilova, Marie; Rudnai, Peter; Świątkowska, Beata; Benhamou, Simone; Cancel-Tassin, Geraldine; Cussenot, Olivier; Trichopoulou, Antonia; Riboli, Elio; Overvad, Kim; Panico, Salvatore; Ljungberg, Borje; Sitaram, Raviprakash T; Giles, Graham G; Milne, Roger L; Severi, Gianluca; Bruinsma, Fiona; Fletcher, Tony; Koppova, Kvetoslava; Larsson, Susanna C; Wolk, Alicja; Banks, Rosamonde E; Selby, Peter J; Easton, Douglas F; Pharoah, Paul; Andreotti, Gabriella; Beane Freeman, Laura E; Koutros, Stella; Albanes, Demetrius; Männistö, Satu; Weinstein, Stephanie; Clark, Peter E; Edwards, Todd L; Lipworth, Loren; Carol, Hallie; Freedman, Matthew L; Pomerantz, Mark M; Cho, Eunyoung; Kraft, Peter; Preston, Mark A; Wilson, Kathryn M; Michael Gaziano, J; Sesso, Howard D; Black, Amanda; Freedman, Neal D; Huang, Wen-Yi; Anema, John G; Kahnoski, Richard J; Lane, Brian R; Noyes, Sabrina L; Petillo, David; Teh, Bin Tean; Peters, Ulrike; White, Emily; Anderson, Garnet L; Johnson, Lisa; Luo, Juhua; Chow, Wong-Ho; Moore, Lee E; Choueiri, Toni K; Wood, Christopher; Johansson, Mattias; McKay, James D; Brown, Kevin M; Rothman, Nathaniel; Lathrop, Mark G; Deleuze, Jean-Francois; Wu, Xifeng; Brennan, Paul; Chanock, Stephen J; Purdue, Mark P; Scelo, Ghislaine

European journal of human genetics. 2019 Oct; 27(10):1589-1598

Guedes, Liana B; Morais, Carlos L; Fedor, Helen; Hicks, Jessica; Gurel, Bora; Melamed, Jonathan; Lee, Peng; Gopalan, Anuradha; Knudsen, Beatrice S; True, Lawrence D; Scher, Howard I; Fine, Samson W; Trock, Bruce J; De Marzo, Angelo M; Lotan, Tamara L

Archives of pathology & laboratory medicine. 2019 Mar; 143(3):338-348

Wang, Yu; Schafler, Eric D; Thomas, Phillip A; Ha, Susan; David, Gregory; Adney, Emily; Garabedian, Michael J; Lee, Peng; Logan, Susan K

Oncotarget. 2019 Jan 22; 10(7):707-716

Zhao, Yani; Deng, Fang-Ming; Huang, Hongying; Lee, Peng; Lepor, Hebert; Rosenkrantz, Andrew B; Taneja, Samir; Melamed, Jonathan; Zhou, Ming

Archives of pathology & laboratory medicine. 2019 Jan; 143(1):86-91