Peng Lee, MD

Professor, Department of Pathology

Professor, Department of Urology

Keywords
cancer, Androgen receptor and its cofactors and target genes in prostate and breast cancer
Summary

The principal research focus of our group is to elucidate the molecular mechanism of hormonal (androgen and estrogen) receptors, their cofactors, and their target genes in the development of endocrine organs and malignancies, including breast and prostate cancers. In particular, we are interested in understanding the molecular mechanisms underlying the development of androgen-independent prostate cancer. A compelling element of our research is to understand how the expression and function of proteins in the stromal androgen receptor (AR) pathway influences the stromal-epithelial interactions, contributing to tumorigenesis. The long term goal of the lab is to apply these findings to clinically relevant issues; to identify prognostic or predictive biomarkers, and to discover novel therapeutic strategies for these cancers.

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Professor, Department of Pathology

Professor, Department of Urology

MD from University Peking

Gleason Score 7 and 8 Prostate Cancer with Cribriform Morphology Diagnosed in Prostate Biopsy Is More Likely to Have Seminal Vesicle Invasion and Pelvic Lymph Node Metastasis in Radical Prostatectomy [Meeting Abstract]

Wang, Ling; Deng, Fang-Ming; Huang, Hongying; Lee, Peng; Melamed, Jonathan; Zhou, Ming

Laboratory investigation. 2017 Feb; 97:264A-264A

Gleason Score 3+4=7 Prostate Carcinomas Detected by MRI-Targeted Biopsies Contain Higher Percentage of Pattern 4 and Are Less Likely to Be Upgraded in Radical Prostatectomies [Meeting Abstract]

Zhao, Yani; Deng, Fang-Ming; Huang, Hongying; Lee, Peng; Melamed, Jonathan; Zhou, Ming

Laboratory investigation. 2017 Feb; 97:270A-270A

Comparison of Standard and MRI Targeted Biopsy in Anterior Predominant Prostate Cancer [Meeting Abstract]

Peng, Yu-Ching; Wang, Ying; Huang, Hongying; Lee, Peng; Melamed, Jonathan; Zhou, Ming; Deng, Fang-Ming

Laboratory investigation. 2017 Feb; 97:248A-248A

Clinical Significance of Tertiary Pattern 4 in Gleason 3+3=6 Adenocarcinoma of the Prostate [Meeting Abstract]

Barna, Nicholas; Ettel, Mark; Chen, Fei; Lee, Peng; Huang, Hongying; Melamed, Jonathan; Zhou, Ming; Deng, Fang-Ming

Laboratory investigation. 2017 Feb; 97:213A-213A

Prostate Neuroendocrine Tumors: Clinicopathological Study of 15 Cases with Emphasis on the Neuroendocrine Tumors of the "Intermemdiate Grade" and Overlapping Features [Meeting Abstract]

Zhao, Yani; Deng, Fang-Ming; Huang, Hongying; Lee, Peng; Melamed, Jonathan; Zhou, Ming

Laboratory investigation. 2017 Feb; 97:270A-270A

MRI-Targeted Prostate Biopsy Detects More Cribriform Prostate Carcinoma Than Standard Sextant Prostate Biopsy [Meeting Abstract]

Wang, Ying; Deng, Fang-Ming; Huang, Hongying; Lee, Peng; Melamed, Jonathan; Zhou, Ming

Laboratory investigation. 2017 Feb; 97:264A-264A

Prostate Neuroendocrine Tumors: Clinicopathological Study of 15 Cases with Emphasis on the Neuroendocrine Tumors of the "Intermemdiate Grade" and Overlapping Features [Meeting Abstract]

Zhao, Yani; Deng, Fang-Ming; Huang, Hongying; Lee, Peng; Melamed, Jonathan; Zhou, Ming

Modern pathology. 2017 Feb; 30:270A-270A

Clinical Significance of Tertiary Pattern 4 in Gleason 3+3=6 Adenocarcinoma of the Prostate [Meeting Abstract]

Barna, Nicholas; Ettel, Mark; Chen, Fei; Lee, Peng; Huang, Hongying; Melamed, Jonathan; Zhou, Ming; Deng, Fang-Ming

Modern pathology. 2017 Feb; 30:213A-213A