Ralf Duerr

Ralf Duerr, MD, PhD

Research Associate Professor, Department of Medicine

Keywords
Molecular virology, Host-virus interaction, HIV, SARS-CoV-2, MPOX, Influenza, Adaptive evolution and structure-function relationships, Antiviral adaptive and innate immune responses, Immune correlates of protection/disease progression, Mechanisms of antiretroviral drug resistance, Superinfection and epidemiologically-linked infection, Emerging viruses and recombinant forms, Viral diversity in West and Central Africa, Serological profiling, Viral entry
Summary

My laboratory focuses on the functional and genomic dimensions of viral infections, including but not limited to SARS-CoV-2, HIV-1, mpox, and Influenza. We delve into the intricate study of antiviral immune responses against these viruses. Our research encompasses profiling serological responses and characterizing emerging viral strains and recombinant forms. We also investigate the genomic and clinical attributes related to vaccine escape. Our work extends to understanding the immune correlates associated with protection and disease progression, as well as exploring the mechanisms behind drug resistance.

Phone

212-263-4159

Academic office

ACLS, West Tower, 430 East 29th Street

3rd Floor, Room 323

New York City, NY 10016

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Positions

Research Associate Professor, Department of Medicine at NYU Grossman School of Medicine

Selective adaptation of SARS-CoV-2 Omicron under booster vaccine pressure: a multicentre observational study

Duerr, Ralf; Dimartino, Dacia; Marier, Christian; Zappile, Paul; Wang, Guiqing; François, Fritz; Ortigoza, Mila B; Iturrate, Eduardo; Samanovic, Marie I; Mulligan, Mark J; Heguy, Adriana

EBioMedicine. 2023 Nov; 97:104843

Longitudinal humoral immunity against SARS-CoV-2 Spike following infection in individuals from Cameroon

Benlarbi, Mehdi; Kenfack, Dell-Dylan; Dionne, Katrina; Côté-Chenette, Maxime; Beaudoin-Bussières, Guillaume; Bélanger, Étienne; Ding, Shilei; Goni, Oumarou H; Ngoume, Yannick F; Tauzin, Alexandra; Medjahed, Halima; Ghedin, Elodie; Duerr, Ralf; Finzi, Andrés; Tongo, Marcel

Virology. 2025 Apr; 605:110467

The two-dose MVA-BN mpox vaccine induces a nondurable and low avidity MPXV-specific antibody response

Oom, Aaron L; Wilson, Kesi K; Yonatan, Miilani; Rettig, Stephanie; Youn, Heekoung Allison; Tuen, Michael; Shah, Yusra; DuMont, Ashley L; Belli, Hayley M; Zucker, Jane R; Rosen, Jennifer B; Herati, Ramin Sedaghat; Samanovic, Marie I; Duerr, Ralf; Kottkamp, Angelica C; Mulligan, Mark J; ,

Journal of virology. 2025 Mar 31; e0025325

Post-transfusion activation of coagulation pathways during severe COVID-19 correlates with COVID-19 convalescent plasma antibody profiles

Weiss, Svenja; Lin, Hung-Mo; Acosta, Eric; Komarova, Natalia L; Chen, Ping; Wodarz, Dominik; Baine, Ian; Duerr, Ralf; Wajnberg, Ania; Gervais, Adrian; Bastard, Paul; Casanova, Jean-Laurent; Arinsburg, Suzanne A; Swartz, Talia H; Aberg, Judith A; Bouvier, Nicole M; Liu, Sean Th; Alvarez, Raymond A; Chen, Benjamin K

The Journal of clinical investigation. 2025 Mar 17; 135(6):

Vaccine Equity: Lessons Learned Exploring Facilitators and Barriers to COVID-19 Vaccination in Urban Black Communities

Parameswaran, Lalitha; Jaysing, Anna; Ding, Helen; Wilkenfeld, Marc; Dean, Ranekka; Wilson, Kesi K; Frank, Olivia; Duerr, Ralf; Mulligan, Mark J

Journal of racial & ethnic health disparities. 2024 Aug; 11(4):2109-2119

Impaired immune responses in the airways are associated with poor outcome in critically ill COVID-19 patients

Barnett, Clea R; Krolikowski, Kelsey; Postelnicu, Radu; Mukherjee, Vikramjit; Sulaiman, Imran; Chung, Matthew; Angel, Luis; Tsay, Jun-Chieh J; Wu, Benjamin G; Yeung, Stephen T; Duerr, Ralf; Desvignes, Ludovic; Khanna, Kamal; Li, Yonghua; Schluger, Rosemary; Rafeq, Samaan; Collazo, Destiny; Kyeremateng, Yaa; Amoroso, Nancy; Pradhan, Deepak; Das, Sanchita; Evans, Laura; Uyeki, Timothy M; Ghedin, Elodie; Silverman, Gregg J; Segal, Leopoldo N; Brosnahan, Shari B

ERJ open research. 2024 Jul; 10(4):

Plasmatic HIV-1 soluble gp120 is associated with correlates of immune dysfunction and inflammation in ART-treated individuals with undetectable viremia

Benlarbi, Mehdi; Richard, Jonathan; Bourassa, Catherine; Tolbert, William D; Chartrand-Lefebvre, Carl; Gendron-Lepage, Gabrielle; Sylla, Mohamed; El-Far, Mohamed; Messier-Peet, Marc; Guertin, Camille; Turcotte, Isabelle; Fromentin, Rémi; Verly, Myriam Maude; Prévost, Jérémie; Clark, Andrew; Mothes, Walther; Kaufmann, Daniel E; Maldarelli, Frank; Chomont, Nicolas; Bégin, Philippe; Tremblay, Cécile; Baril, Jean-Guy; Trottier, Benoit; Trottier, Sylvie; Duerr, Ralf; Pazgier, Marzena; Durand, Madeleine; Finzi, Andrés

Journal of infectious diseases. 2024 Mar 14; 229(3):763-774

Phylogenetic evidence of extensive spatial mixing of diverse HIV-1 group M lineages within Cameroon but not between its neighbours

Godwe, Célestin; Goni, Oumarou H; San, James E; Sonela, Nelson; Tchakoute, Mérimé; Nanfack, Aubin; Koro, Francioli K; Butel, Christelle; Vidal, Nicole; Duerr, Ralf; Martin, Darren P; de Oliveira, Tulio; Peeters, Martine; Altfeld, Marcus; Ayouba, Ahidjo; Ndung'u, Thumbi; Tongo, Marcel

Virus evolution. 2024 Oct; 10(1):veae070

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