Ran Brosh, PhD

My research at the Institute for Systems Genetics (ISG), focuses on leveraging genome engineering to model human diseases and to investigate fundamental biological processes, including development and evolution. I am particularly interested in exploring the genome’s "dark matter"—the extensive non-coding regions such as intergenic sequences, introns, and transposable elements—and understanding their roles in development, evolution, and disease. Additionally, I am dedicated to advancing genome engineering technologies.​

As Associate Director of the Rodent Genetic Engineering Laboratory (RGEL), I design and implement strategies to engineer mouse embryonic stem cells and develop complex mouse models, thereby contributing to progress in biomedical research.