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Ravichandran Ramasamy

Ravichandran Ramasamy, PhD

Professor, Department of Medicine

Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
cardiovascular biology, metabolism, myocardial ischemia reperfusion injury, diabetic atherosclerosis, diabetic cardiovascular complications
Summary

The main focus of our research efforts is to understand the metabolic and inflammatory mechanisms underlying diabetic cardiovascular complications. In this context, our work has led to several novel findings that (a) the glucose metabolizing enzyme, aldose reductase (AR) plays critical role in the pathogenesis of myocardial ischemic injury, (b) advanced glycation end products (AGEs) modulates cardiomyocyte injury during ischemia-reperfusion injury in diabetics and non-diabetics via RAGE pathway driven signaling mechanisms, and (c) AR-driven mechanisms, in part, mediate acceleration and progression of atherosclerosis in diabetics.  .

Specific areas of investigations are:

1)      Elucidating mechanisms by which flux via AR drives acetylation of metabolic, transcriptional, and antioxidant enzymes in ischemic, diabetic, and aging heart.

2)      Mechanisms by which RAGE tail binding partner Diaph1, in part, mediates cardiac aging and myocardial ischemic injury.  Specifically, studies will address how Diaph1-driven changes in actin cytoskeleton dynamics mediate cardiac aging and increased vulnerability of the heart to ischemic stress.  

3)      Dissection of the RAGE/Diaph1 driven mechanisms mediating macrophage recruitment, retention, and inflammatory actions in impaired regression of diabetic atherosclerosis.

Driven by the complexities of mechanisms that underlie myocardial ischemic injury and heart failure, the goal of my laboratory is to elucidate the importance of AR and AGE-RAGE pathways in mediating ischemic injury, metabolic imbalances, heart failure and diabetic atherosclerosis.  It is my hope and expectation that interventions that block AR and/ AGE-RAGE pathways will be employed in the near future to treat patients with evolving myocardial infarction and diabetic cardiovascular complications.

These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.
Ramasamy, Ravichandran; Shekhtman, Alexander; Schmidt, Ann Marie

International journal of molecular sciences. 2022 Apr 21; 23(9):

Manigrasso, Michaele B; Rabbani, Piul; Egaña-Gorroño, Lander; Quadri, Nosirudeen; Frye, Laura; Zhou, Boyan; Reverdatto, Sergey; Ramirez, Lisa S; Dansereau, Stephen; Pan, Jinhong; Li, Huilin; D'Agati, Vivette D; Ramasamy, Ravichandran; DeVita, Robert J; Shekhtman, Alexander; Schmidt, Ann Marie

Science translational medicine. 2021 Nov 24; 13(621):eabf7084

Gaztanaga, Juan; Ramasamy, Ravichandran; Schmidt, Ann Marie; Fishman, Glenn; Schendelman, Shoshana; Thangavelu, Karthinathan; Perfetti, Riccardo; Katz, Stuart D

Diabetes & metabolic syndrome. 2021 Oct 30; 15(6):102328

López-Díez, Raquel; Egaña-Gorroño, Lander; Senatus, Laura; Shekhtman, Alexander; Ramasamy, Ravichandran; Schmidt, Ann Marie

Current cardiology reports. 2021 06 03; 23(7):74

Senatus, Laura; MacLean, Michael; Arivazhagan, Lakshmi; Egaña-Gorroño, Lander; López-Díez, Raquel; Manigrasso, Michaele B; Ruiz, Henry H; Vasquez, Carolina; Wilson, Robin; Shekhtman, Alexander; Gugger, Paul F; Ramasamy, Ravichandran; Schmidt, Ann Marie

Immunometabolism. 2021 Jun; 3(3):

Jannapureddy, Sravya; Sharma, Mira; Yepuri, Gautham; Schmidt, Ann Marie; Ramasamy, Ravichandran

Frontiers in endocrinology. 2021 Oct; 12:636267

Kadosh, Bernard S; Garshick, Michael S; Gaztanaga, Juan; Moore, Kathryn J; Newman, Jonathan D; Pillinger, Michael; Ramasamy, Ravichandran; Reynolds, Harmony R; Shah, Binita; Hochman, Judith; Fishman, Glenn I; Katz, Stuart D

Arteriosclerosis, thrombosis, & vascular biology. 2020 Jul 20; ATVBAHA120314513