The main focus of our research efforts is to understand the metabolic and inflammatory mechanisms underlying diabetic cardiovascular complications. In this context, our work has led to several novel findings that (a) the glucose metabolizing enzyme, aldose reductase (AR) plays critical role in the pathogenesis of myocardial ischemic injury, (b) advanced glycation end products (AGEs) modulates cardiomyocyte injury during ischemia-reperfusion injury in diabetics and non-diabetics via RAGE pathway driven signaling mechanisms, and (c) AR-driven mechanisms, in part, mediate acceleration and progression of atherosclerosis in diabetics. .
Specific areas of investigations are:
1) Elucidating mechanisms by which flux via AR drives acetylation of metabolic, transcriptional, and antioxidant enzymes in ischemic, diabetic, and aging heart.
2) Mechanisms by which RAGE tail binding partner Diaph1, in part, mediates cardiac aging and myocardial ischemic injury. Specifically, studies will address how Diaph1-driven changes in actin cytoskeleton dynamics mediate cardiac aging and increased vulnerability of the heart to ischemic stress.
3) Dissection of the RAGE/Diaph1 driven mechanisms mediating macrophage recruitment, retention, and inflammatory actions in impaired regression of diabetic atherosclerosis.
Driven by the complexities of mechanisms that underlie myocardial ischemic injury and heart failure, the goal of my laboratory is to elucidate the importance of AR and AGE-RAGE pathways in mediating ischemic injury, metabolic imbalances, heart failure and diabetic atherosclerosis. It is my hope and expectation that interventions that block AR and/ AGE-RAGE pathways will be employed in the near future to treat patients with evolving myocardial infarction and diabetic cardiovascular complications.
Professor, Department of Medicine
Professor, Department of Biochemistry and Molecular Pharmacology
PhD from Loyola University
Diabetes. 2018 Sep 13; 67(9):1880-1891
American journal of physiology. Renal physiology. 2018 Aug 22;
Scientific reports. 2018 Jul 27; 8(1):11327-11327
PLoS one. 2018 May 30; 13(5):e0198119-e0198119
Journal of translational science. 2018 Apr 16; 4(2):1-9
Aldose reductase driven changes in genes linked to fatty acid metabolism and cellular senescence in high fat diet fed mice [Meeting Abstract]
Journal of the American Geriatrics Society. 2018 APR; 66:S295-S295
Small molecule antagonists of RAGE-DIAPH1: Novel therapeutic opportunities in metabolic and chronic disease [Meeting Abstract]
FASEB journal. 2018 April; Conference:(Experimental):
Journal of translational science. 2018 Mar 14; 4(2):