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Ravichandran Ramasamy

Ravichandran Ramasamy, PhD

Professor, Department of Medicine

Professor, Department of Biochemistry and Molecular Pharmacology

cardiovascular biology, metabolism, myocardial ischemia reperfusion injury, diabetic atherosclerosis, diabetic cardiovascular complications

The main focus of our research efforts is to understand the metabolic and inflammatory mechanisms underlying diabetic cardiovascular complications. In this context, our work has led to several novel findings that (a) the glucose metabolizing enzyme, aldose reductase (AR) plays critical role in the pathogenesis of myocardial ischemic injury, (b) advanced glycation end products (AGEs) modulates cardiomyocyte injury during ischemia-reperfusion injury in diabetics and non-diabetics via RAGE pathway driven signaling mechanisms, and (c) AR-driven mechanisms, in part, mediate acceleration and progression of atherosclerosis in diabetics.  .

Specific areas of investigations are:

1)      Elucidating mechanisms by which flux via AR drives acetylation of metabolic, transcriptional, and antioxidant enzymes in ischemic, diabetic, and aging heart.

2)      Mechanisms by which RAGE tail binding partner Diaph1, in part, mediates cardiac aging and myocardial ischemic injury.  Specifically, studies will address how Diaph1-driven changes in actin cytoskeleton dynamics mediate cardiac aging and increased vulnerability of the heart to ischemic stress.  

3)      Dissection of the RAGE/Diaph1 driven mechanisms mediating macrophage recruitment, retention, and inflammatory actions in impaired regression of diabetic atherosclerosis.

Driven by the complexities of mechanisms that underlie myocardial ischemic injury and heart failure, the goal of my laboratory is to elucidate the importance of AR and AGE-RAGE pathways in mediating ischemic injury, metabolic imbalances, heart failure and diabetic atherosclerosis.  It is my hope and expectation that interventions that block AR and/ AGE-RAGE pathways will be employed in the near future to treat patients with evolving myocardial infarction and diabetic cardiovascular complications.

These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication

Professor, Department of Medicine

Professor, Department of Biochemistry and Molecular Pharmacology

PhD from Loyola University

MacLean, Michael; Derk, Julia; Ruiz, Henry H; Juranek, Judyta K; Ramasamy, Ravichandran; Schmidt, Ann Marie

Neurochemistry international. 2019 Mar 20; 126:154-164

Manigrasso, Michaele B; Friedman, Richard A; Ramasamy, Ravichandran; D'Agati, Vivette D; Schmidt, Ann Marie

American journal of physiology. Renal physiology. 2018 Dec 01; 315(6):F1601-F1612

Deletion of the formin Diaph1 protects from structural and functional abnormalities in the murine diabetic kidney

Manigrasso, M B; Friedman, R A; Ramasamy, R; D'agati, V; Schmidt, A M

American journal of physiology. Renal, fluid & electrolyte physiology. 2018 December; 315(6):F1601-F1612

Ramasamy, Ravichandran; Friedman, Richard A; Shekhtman, Alexander; Schmidt, Ann Marie

Expert review of proteomics. 2018 Oct 16;

Yuan, Chujun; Hu, Jiyuan; Parathath, Saj; Grauer, Lisa; Cassella, Courtney Blachford; Bagdasarov, Svetlana; Goldberg, Ira J; Ramasamy, Ravichandran; Fisher, Edward A

Diabetes. 2018 09; 67(9):1880-1891

Vallès, Yvonne; Inman, Claire K; Peters, Brandilyn A; Ali, Raghib; Wareth, Laila Abdel; Abdulle, Abdishakur; Alsafar, Habiba; Anouti, Fatme Al; Dhaheri, Ayesha Al; Galani, Divya; Haji, Muna; Hamiz, Aisha Al; Hosani, Ayesha Al; Houqani, Mohammed Al; Junaibi, Abdulla Al; Kazim, Marina; Kirchhoff, Tomas; Mahmeed, Wael Al; Maskari, Fatma Al; Alnaeemi, Abdullah; Oumeziane, Naima; Ramasamy, Ravichandran; Schmidt, Ann Marie; Weitzman, Michael; Zaabi, Eiman Al; Sherman, Scott; Hayes, Richard B; Ahn, Jiyoung

Scientific reports. 2018 Jul 27; 8(1):11327

Aldose reductase driven changes in genes linked to fatty acid metabolism and cellular senescence in high fat diet fed mice [Meeting Abstract]

Sekaran, K.; Thiagarajan, D.; Ramasamy, R.

Journal of the American Geriatrics Society. 2018 APR; 66:S295-S295

Small molecule antagonists of RAGE-DIAPH1: Novel therapeutic opportunities in metabolic and chronic disease [Meeting Abstract]

Manigrasso, M B; Quadri, N; Li, Q; DeVita, R J; Ramasamy, R; Shekhtman, A; Schmidt, A M

FASEB journal. 2018 April; Conference:(Experimental):