Richard L. Possemato

Richard L. Possemato, PhD

Assistant Professor, Department of Pathology

Keywords
tumor metabolism, genetic screening, breast cancer, mitochondrialfFunction, serine biosynthesis, cancer, metabolism, pharmacology
Summary

Our laboratory focuses on identifying metabolic pathways that are altered in the transformed state, understanding how those pathways support transformation, and investigating the environmental, genetic and epigenetic contexts in which such pathways act. Of particular interest are investigating serine and glycine metabolism and iron-sulfur cluster metabolism as well as exploring the potential ways by which mutations in the mitochondrial genome support cellular transformation. We attack these problems with a combination of approaches that endeavor to push the boundaries of genetic screening, mammalian cell culture, and metabolomic methods. Visit our lab website at: http://possematolab.com

Academic office

550 First Avenue

MSB 504

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Assistant Professor, Department of Pathology

PhD from Harvard University

Whitehead Institute, MIT, Sabatini Lab

Birsoy, Kivanc; Possemato, Richard; Lorbeer, Franziska K; Bayraktar, Erol C; Thiru, Prathapan; Yucel, Burcu; Wang, Tim; Chen, Walter W; Clish, Clary B; Sabatini, David M

Nature. 2014 Apr 03; 508(7494):108-112

Possemato, Richard; Marks, Kevin M; Shaul, Yoav D; Pacold, Michael E; Kim, Dohoon; Birsoy, Kivanc; Sethumadhavan, Shalini; Woo, Hin-Koon; Jang, Hyun G; Jha, Abhishek K; Chen, Walter W; Barrett, Francesca G; Stransky, Nicolas; Tsun, Zhi-Yang; Cowley, Glenn S; Barretina, Jordi; Kalaany, Nada Y; Hsu, Peggy P; Ottina, Kathleen; Chan, Albert M; Yuan, Bingbing; Garraway, Levi A; Root, David E; Mino-Kenudson, Mari; Brachtel, Elena F; Driggers, Edward M; Sabatini, David M

Nature. 2011 Aug 18; 476(7360):346-350

Tsun, Zhi-Yang; Possemato, Richard

Seminars in cell & developmental biology. 2015 Jul; 43:22-32

Kim, Dohoon; Fiske, Brian P; Birsoy, Kivanc; Freinkman, Elizaveta; Kami, Kenjiro; Possemato, Richard L; Chudnovsky, Yakov; Pacold, Michael E; Chen, Walter W; Cantor, Jason R; Shelton, Laura M; Gui, Dan Y; Kwon, Manjae; Ramkissoon, Shakti H; Ligon, Keith L; Kang, Seong Woo; Snuderl, Matija; Vander Heiden, Matthew G; Sabatini, David M

Nature. 2015 Apr 16; 520(7547):363-367

Grabiner, Brian C; Nardi, Valentina; Birsoy, Kivanc; Possemato, Richard; Shen, Kuang; Sinha, Sumi; Jordan, Alexander; Beck, Andrew H; Sabatini, David M

Cancer discovery. 2014 May; 4(5):554-563

Pacold, Michael E; Brimacombe, Kyle R; Chan, Sze Ham; Rohde, Jason M; Lewis, Caroline A; Swier, Lotteke J Y M; Possemato, Richard; Chen, Walter W; Sullivan, Lucas B; Fiske, Brian P; Cho, Steve; Freinkman, Elizaveta; Birsoy, Kivanc; Abu-Remaileh, Monther; Shaul, Yoav D; Liu, Chieh Min; Zhou, Minerva; Koh, Min Jung; Chung, Haeyoon; Davidson, Shawn M; Luengo, Alba; Wang, Amy Q; Xu, Xin; Yasgar, Adam; Liu, Li; Rai, Ganesha; Westover, Kenneth D; Vander Heiden, Matthew G; Shen, Min; Gray, Nathanael S; Boxer, Matthew B; Sabatini, David M

Nature chemical biology. 2016 Jun; 12(6):452-458

Strohecker, A M; Joshi, S; Possemato, R; Abraham, R T; Sabatini, D M; White, E

Oncogene. 2015 Nov 05; 34(45):5662-5676

Vaeth, Martin; Maus, Mate; Klein-Hessling, Stefan; Freinkman, Elizaveta; Yang, Jun; Eckstein, Miriam; Cameron, Scott; Turvey, Stuart E; Serfling, Edgar; Berberich-Siebelt, Friederike; Possemato, Richard; Feske, Stefan

Immunity. 2017 Oct 17; 47(4):664-679.e6