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Richard L. Possemato

Richard L. Possemato, PhD

Associate Professor, Department of Pathology

Keywords
tumor metabolism, iron-sulfur clusters, breast cancer, mitochondrial function, serine biosynthesis, cancer, metabolism, mTOR
Summary

Our laboratory focuses on identifying metabolic pathways that are altered in the transformed state, understanding how those pathways support transformation, and investigating the environmental, genetic and epigenetic contexts in which such pathways act. Of particular interest are investigating serine and glycine metabolism and iron-sulfur cluster metabolism as well as exploring the potential ways by which mutations in the mitochondrial genome support cellular transformation. We attack these problems with a combination of approaches that endeavor to push the boundaries of genetic screening, mammalian cell culture, and metabolomic methods. Visit our lab website at: http://possematolab.med.nyu.edu/

Academic office

550 First Avenue

Smilow 611

New York, NY 10016

Lab Website
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PhD from Harvard University

Whitehead Institute, MIT, Sabatini Lab

Alvarez, Samantha W; Sviderskiy, Vladislav O; Terzi, Erdem M; Papagiannakopoulos, Thales; Moreira, Andre L; Adams, Sylvia; Sabatini, David M; Birsoy, Kivanc; Possemato, Richard

Nature. 2017 11 30; 551(7682):639-643

Terzi, Erdem M; Sviderskiy, Vladislav O; Alvarez, Samantha W; Whiten, Gabrielle C; Possemato, Richard

Science advances. 2021 May; 7(22):

Sviderskiy, Vladislav O; Blumenberg, Lili; Gorodetsky, Elizabeth; Karakousi, Triantafyllia R; Hirsh, Nicole; Alvarez, Samantha W; Terzi, Erdem M; Kaparos, Efiyenia; Whiten, Gabrielle C; Ssebyala, Shakirah; Tonzi, Peter; Mir, Hannan; Neel, Benjamin G; Huang, Tony T; Adams, Sylvia; Ruggles, Kelly V; Possemato, Richard

Molecular cell. 2020 Nov 19; 80(4):682-698.e7

Minton, Denise R; Nam, Minwoo; McLaughlin, Daniel J; Shin, Jong; Bayraktar, Erol C; Alvarez, Samantha W; Sviderskiy, Vladislav O; Papagiannakopoulos, Thales; Sabatini, David M; Birsoy, Kıvanç; Possemato, Richard

Molecular cell. 2018 02 15; 69(4):610-621.e5

Possemato, Richard; Marks, Kevin M; Shaul, Yoav D; Pacold, Michael E; Kim, Dohoon; Birsoy, Kivanc; Sethumadhavan, Shalini; Woo, Hin-Koon; Jang, Hyun G; Jha, Abhishek K; Chen, Walter W; Barrett, Francesca G; Stransky, Nicolas; Tsun, Zhi-Yang; Cowley, Glenn S; Barretina, Jordi; Kalaany, Nada Y; Hsu, Peggy P; Ottina, Kathleen; Chan, Albert M; Yuan, Bingbing; Garraway, Levi A; Root, David E; Mino-Kenudson, Mari; Brachtel, Elena F; Driggers, Edward M; Sabatini, David M

Nature. 2011 Aug 18; 476(7360):346-50

Birsoy, Kivanc; Possemato, Richard; Lorbeer, Franziska K; Bayraktar, Erol C; Thiru, Prathapan; Yucel, Burcu; Wang, Tim; Chen, Walter W; Clish, Clary B; Sabatini, David M

Nature. 2014 Apr 03; 508(7494):108-12

Tsun, Zhi-Yang; Possemato, Richard

Seminars in cell & developmental biology. 2015 Jul; 43:22-32

Sviderskiy, Vladislav O.; Terzi, Erdem M.; Possemato, Richard

Ferroptosis in Health and Disease. [S.l.] : Springer International Publishing, 2019. p.215-237. (4508572)