Research Professor, Department of Neuroscience and Physiology
Professor Emeritus of Neuroscience and Physiology, Department of Neuroscience and Physiology
University Professor, Department of Neuroscience and Physiology
Our research pertains mostly to neuroscience from the molecular to the cognitive level. We focus on the intrinsic electrophysiological properties of mammalian neurons in vitro, where we correlate ionic conductances with the different molecular structures (channels) responsible for them. In particular, we study the ionic channels that generate some of the sodium and calcium currents responsible for the electrophysiological properties of neurons and their distribution in different cell types (Purkinje-cell and inferior-olivary neurons as well as thalamic and cortical neurons). We also investigate the role of calcium conductance in synaptic transmission in the squid giant synapse, where we demonstrated for the first time the concept of calcium microdomains. At the neuronal-circuit level, we examine cerebellar control of movement and thalamocortical connectivity, as observed in brain slices and isolated wholebrain preparation, using single- and multiple-recording microprobes and ionic-concentration-dependent imaging techniques. We place these studies at the light and ultrastructural levels and analyze them using computer-based mathematical models. At the cognitive level, we focus on thalamocortical interaction and functional mapping in the human brain, using noninvasive magnetoencephalography.
212-263-5415
550 First Avenue
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New York, NY 10016
Research Professor, Department of Neuroscience and Physiology at NYU Grossman School of Medicine
Professor Emeritus of Neuroscience and Physiology, Department of Neuroscience and Physiology at NYU Grossman School of Medicine
University Professor, Department of Neuroscience and Physiology at NYU Grossman School of Medicine
Frontiers in aging neuroscience. 2022 Mar; 14:813531
Plant signaling & behavior. 2021 Jun 12; 1927562
Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2020 Dec 29; 117(52):33578-33585
Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2020 Mar 03; 117(9):4942-4947
Science. 2017 10 27; 358(6362):482-485
Muscle & nerve. 2017 04; 55(4):555-563
Frontiers in human neuroscience. 2017 Dec; 11:24
Neuroscience. 2016 06 14; 325:30-8