Rodolfo Llinas

Rodolfo Llinas

Neuroscience Institute

Thomas and Suzanne Murphy Professor of Neuroscience, Department of Neuroscience and Physiology

University Professor, Department of Neuroscience and Physiology

Keywords
intrinsic properties of neurons
Summary

Our research pertains mostly to neuroscience from the molecular to the cognitive level. We focus on the intrinsic electrophysiological properties of mammalian neurons in vitro, where we correlate ionic conductances with the different molecular structures (channels) responsible for them. In particular, we study the ionic channels that generate some of the sodium and calcium currents responsible for the electrophysiological properties of neurons and their distribution in different cell types (Purkinje-cell and inferior-olivary neurons as well as thalamic and cortical neurons). We also investigate the role of calcium conductance in synaptic transmission in the squid giant synapse, where we demonstrated for the first time the concept of calcium microdomains. At the neuronal-circuit level, we examine cerebellar control of movement and thalamocortical connectivity, as observed in brain slices and isolated wholebrain preparation, using single- and multiple-recording microprobes and ionic-concentration-dependent imaging techniques. We place these studies at the light and ultrastructural levels and analyze them using computer-based mathematical models. At the cognitive level, we focus on thalamocortical interaction and functional mapping in the human brain, using noninvasive magnetoencephalography.

Phone

212-263-5415

Academic office

550 First Avenue

Fourth Floor

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Thomas and Suzanne Murphy Professor of Neuroscience, Department of Neuroscience and Physiology

University Professor, Department of Neuroscience and Physiology

Llinas, Rodolfo; Moreno, Herman

Alzheimer's & dementia. 2017 Feb; 13(2):196-197

Ivannikov, Maxim V; Sugimori, Mutsuyuki; Llinas, Rodolfo R

Muscle & nerve. 2017 Jan 10; 55(4):555-563

Walton, Kerry D; Maillet, Emeline L; Garcia, John; Cardozo, Timothy; Galatzer-Levy, Isaac; Llinas, Rodolfo R

Frontiers in human neuroscience. 2017; 11:24-24

Moreno, H; Morfini, G; Buitrago, L; Ujlaki, G; Choi, S; Yu, E; Moreira, J E; Avila, J; Brady, S T; Pant, H; Sugimori, M; Llinas, R R

Neuroscience. 2016 Jun 14; 325:30-38

Choi, Soonwook; Yu, Eunah; Hwang, Eunjin; Llinas, Rodolfo R

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2016 Feb 23; 113(8):2270-2275

De Zeeuw, Chris I; Jaarsma, Dick; Voogd, Jan; Llinas, Rodolfo; Martina, Marco

Cerebellum. 2015 Oct; 14(5):487-490

Choi, Soonwook; Yu, Eunah; Lee, Seongwon; Llinas, Rodolfo R

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 Jun 23; 112(25):7839-7844e001683

Porras, Alex; Llinas, Rodolfo R

Neurocomputing. 2015 MAR 3; 151:11-33