Saran Jonas, M.D. and a multidisciplinary team of investigators are engaged in studies to prevent and treat stroke. At NYUMC/BHC the Clopidogrel vs. Aspirin in Patients at Risk of Ischemic Events (CAPRIE) is comparing a new antiplatelet agent, clopidogrel, to conventional therapy with aspirin in the prevention of recurrent stroke. Eligible patients are randomized within six months of ischemic stroke onset. The NASCET (North American Symptomatic Carotid Endartetectomy Trial) study at NYUMC/BH is random for endarterectomy or medical management within 3 months of event. TIA-minor stroke patients with 30-69% relevant carotid stenosis. The WARSS trial (Warfarin Aspirin Recurrent Stroke Study) at the New York Department of Veterans Affairs Medical Center compares the efficacy of aspirin and warfarin in stroke prevention. Eligible veterans must be enrolled within 30 days of ischemic stroke onset. Also at the New York VAMC, investigators are carrying out a study to refine the recognition of the effects (neuropsychological and other) of cerebral microemboli during cardiac surgery, in order to enhance the ability to use this situation to test neuroprotective drugs.
At Tisch Hospital the use of intra-arterial thrombolytic agents for the treatment of acute stroke is being evaluated in conjunction with the Department of Radiology. Eligible patients are assessed and treated as soon as possible within the first few hours of ischemic stroke symptoms. Two potential neuroprotective agents, lubelozole and eloprodil are also being tested and administered to patients within the first 6 hours of stroke onset.
Clinical Professor, Department of Neurology
Professor Emeritus of Neurology, Department of Neurology
MD from Columbia University
PLoS one. 2016; 11(2):e0149348-e0149348e0149348
Ethnicity & inequalities in health & social care. 2014; 7(3):137-145
Brain research. 2013 Apr 24; 1507:134-145
Neurological research. 2007 Jul; 29(5):469-475
Reply to the letter by Derendorf: Clinical trials and dipyridamole formulation selection [Letter]
Cerebrovascular diseases. 2007 Feb; 23(1):73-74
Cerebrovascular diseases. 2006; 22(1):1-3
Stroke. 2004 Feb; 35(2):537-538