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Sergei B. Koralov

Sergei B. Koralov

Associate Professor, Department of Pathology

Keywords
cancer, immunology, autoimmunity, inflammation, microbiota
Summary
Currently my laboratory is focused on the following questions: 1. How do Th17 cells promote chronic inflammation? We are using several animal model of chronic inflammation that we developed in the lab (COPD and Psoriatic Arthritis) to understand the genesis of tissue specific inflammation. In particular, we are examining the role of antigen stimulation and environmental triggers (namely microbiota and microbial metabolites) in potentiating Th17 mediated chronic inflammation. 2. What is the role of antigen stimulation and microbiota in malignant T cell transformation? We are using a newly established animal model of CTCL and our state of the art gnotobiotic facility to complement our studies of patient biospecimens to address the role of T cell Ag receptor and microbial antigens in the malignant transformation of T lymphocytes. Our focus is on Cutaneous T Cell Lymphoma (CTCL), an enigmatic malignancy of T lymphocytes, characterized by the striking dermal tropism of the malignant cells. 3. What is the role of tumor intrinsic metabolic changes in the suppression of the cancer-specific immune responses? We are taking advantage of our unique access to patient biospecimens and our cutting-edge mouse genetics to dissect how tumors subvert immune surveillance by changing their metabolic profile. Our focus is currently on lung cancer. 4. What is the role of non-coding RNAs in lymphocyte development and function? The emphasis of this project is to both explore the role of individual miRNAs in maintaining lymphoid identity, survival and proliferation; and to understand the contribution of RNAi to Ig locus accessibility during V(D)J recombination, somatic hypermutation and class switch recombination.
Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Associate Professor, Department of Pathology

Wong, Jason B; Hewitt, Susannah L; Heltemes-Harris, Lynn M; Mandal, Malay; Johnson, Kristen; Rajewsky, Klaus; Koralov, Sergei B; Clark, Marcus R; Farrar, Michael A; Skok, Jane A

Nature communications. 2019 Oct 18; 10(1):4768

Herrera, Alberto; Fredholm, Simon; Cheng, Anthony; Mimitou, Eleni P; Seffens, Angelina; Bar-Natan, Michal; Sun, Amy; Latkowski, Joan; Willerslew-Olsen, Andreas; Buus, Terkild B; Gluud, Maria; Krejsgaard, Thorbjørn; Torres-Rusillo, Sara; Bonefeld, Charlotte Menné; Woetmann, Anders; Geisler, Carsten; Geskin, Larisa J; Ouyang, Zhengqing; Smibert, Peter; Ødum, Niels; Koralov, Sergei B

Journal of investigative dermatology. 2019 Aug 26;

Kaufmann, Ulrike; Kahlfuss, Sascha; Yang, Jun; Ivanova, Elitza; Koralov, Sergei B; Feske, Stefan

Cell metabolism. 2019 May 07; 29(5):1104-1118.e6

Mimitou, Eleni P; Cheng, Anthony; Montalbano, Antonino; Hao, Stephanie; Stoeckius, Marlon; Legut, Mateusz; Roush, Timothy; Herrera, Alberto; Papalexi, Efthymia; Ouyang, Zhengqing; Satija, Rahul; Sanjana, Neville E; Koralov, Sergei B; Smibert, Peter

Nature methods. 2019 May; 16(5):409-412

Yen, Wei-Feng; Sharma, Rahul; Cols, Montserrat; Lau, Colleen M; Chaudhry, Ashutosh; Chowdhury, Priyanka; Yewdell, William T; Vaidyanathan, Bharat; Sun, Amy; Coffre, Maryaline; Pucella, Joseph N; Chen, Chun-Chin; Jasin, Maria; Sun, Joseph C; Rudensky, Alexander Y; Koralov, Sergei B; Chaudhuri, Jayanta

Cell reports. 2019 Apr 30; 27(5):1472-1486.e5

Lubkin, Ashira; Lee, Warren L; Alonzo, Francis; Wang, Changsen; Aligo, Jason; Keller, Matthew; Girgis, Natasha M; Reyes-Robles, Tamara; Chan, Rita; O'Malley, Aidan; Buckley, Peter; Vozhilla, Nikollaq; Vasquez, Marilyn T; Su, Johnny; Sugiyama, Michael; Yeung, Stephen T; Coffre, Maryaline; Bajwa, Sofia; Chen, Eric; Martin, Patricia; Kim, Sang Y; Loomis, Cynthia; Worthen, G Scott; Shopsin, Bo; Khanna, Kamal M; Weinstock, Daniel; Lynch, Anthony Simon; Koralov, Sergei B; Loke, P'ng; Cadwell, Ken; Torres, Victor J

Cell host & microbe. 2019 Mar 13; 25(3):463-470.e9

Cantor, David J; King, Bryan; Blumenberg, Lili; DiMauro, Teresa; Aifantis, Iannis; Koralov, Sergei B; Skok, Jane A; David, Gregory

Cell reports. 2019 Jan 02; 26(1):108-118.e4

Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4(+) T cells in cutaneous T-cell lymphoma

Blumel, Edda; Willerslev-Olsen, Andreas; Gluud, Maria; Lindahl, Lise M.; Fredholm, Simon; Nastasi, Claudia; Krejsgaard, Thorbjorn; Surewaard, Bas G. J.; Koralov, Sergei B.; Hu, Tengpeng; Persson, Jenny L.; Bonefeld, Charlotte Menne; Geisler, Carsten; Iversen, Lars; Becker, Juergen C.; Andersen, Mads Hald; Woetmann, Anders; Buus, Terkild Brink; Odum, Niels

Oncoimmunology. 2019;