Shane A. Liddelow

Shane A. Liddelow, PhD

Associate Professor, Department of Neuroscience and Physiology

Associate Professor, Department of Ophthalmology

Keywords
glia, astrocyte, neuroinflammation, neurodegeneration, Alzheimer's disease, reactive astrocyte, neurotoxicity
Summary

My primary focus is on understanding the complex roles of astrocytes in the brain. Astrocytes are a type of glial cell that play crucial roles in maintaining brain homeostasis, supporting neuron function, and responding to injury. My work has particularly centered on a subtype of reactive astrocytes that we discovered, which release toxic factors capable of killing specific neurons.

This discovery has significant implications for neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Amyotrophic Lateral Sclerosis. By studying how these reactive astrocytes contribute to neuroinflammation and neurodegeneration, we aim to uncover the underlying mechanisms that drive these diseases. Our goal is to identify potential therapeutic strategies that can mitigate the harmful effects of these astrocytes, thereby slowing or even halting the progression of neurodegenerative conditions.

Through our research, we hope to pave the way for new treatments that can improve the quality of life for individuals affected by these debilitating diseases. Our ongoing studies continue to explore the intricate interactions between astrocytes and neurons, striving to unlock the mysteries of the brain and develop innovative approaches to combat neurological disorders.

Phone

212-263-8114

Fax

212-263-9170

Academic office

Science Building, 435 East 30th Street

11th Floor, Room 1116

New York, NY 10016

Lab Website
Liddelow Lab
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Positions

Associate Professor, Department of Neuroscience and Physiology at NYU Grossman School of Medicine

Associate Professor, Department of Ophthalmology at NYU Grossman School of Medicine

Graduate Education

PhD from University of Melbourne

Postdoctoral Training

Stanford University, Barres Lab

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, Shane A; Guttenplan, Kevin A; Clarke, Laura E; Bennett, Frederick C; Bohlen, Christopher J; Schirmer, Lucas; Bennett, Mariko L; Munch, Alexandra E; Chung, Won-Suk; Peterson, Todd C; Wilton, Daniel K; Frouin, Arnaud; Napier, Brooke A; Panicker, Nikhil; Kumar, Manoj; Buckwalter, Marion S; Rowitch, David H; Dawson, Valina L; Dawson, Ted M; Stevens, Beth; Barres, Ben A

Nature. 2017 01 26; 541(7638):481-487

Neurotoxic reactive astrocytes induce cell death via saturated lipids

Guttenplan, Kevin A; Weigel, Maya K; Prakash, Priya; Wijewardhane, Prageeth R; Hasel, Philip; Rufen-Blanchette, Uriel; Münch, Alexandra E; Blum, Jacob A; Fine, Jonathan; Neal, Mikaela C; Bruce, Kimberley D; Gitler, Aaron D; Chopra, Gaurav; Liddelow, Shane A; Barres, Ben A

Nature. 2021 Nov; 599(7883):102-107

Molecular and metabolic heterogeneity of astrocytes and microglia

Hasel, Philip; Aisenberg, William H; Bennett, F Chris; Liddelow, Shane A

Cell metabolism. 2023 Apr 04; 35(4):555-570

Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration

Patani, Rickie; Hardingham, Giles E; Liddelow, Shane A

Nature reviews. Neurology. 2023 Jul; 19(7):395-409

Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols

Frazel, Paul W; Labib, David; Fisher, Theodore; Brosh, Ran; Pirjanian, Nicolette; Marchildon, Anne; Boeke, Jef D; Fossati, Valentina; Liddelow, Shane A

Nature neuroscience. 2023 Oct; 26(10):1726-1738

Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference

Kloske, Courtney M; Mahinrad, Simin; Barnum, Christopher J; Batista, Andre F; Bradshaw, Elizabeth M; Butts, Brittany; Carrillo, Maria C; Chakrabarty, Paramita; Chen, Xiaoying; Craft, Suzanne; Da Mesquita, Sandro; Dabin, Luke C; Devanand, Davangere; Duran-Laforet, Violeta; Elyaman, Wassim; Evans, Elizabeth E; Fitzgerald-Bocarsly, Patricia; Foley, Kate E; Harms, Ashley S; Heneka, Michael T; Hong, Soyon; Huang, Yu-Wen A; Jackvony, Stephanie; Lai, Laijun; Guen, Yann Le; Lemere, Cynthia A; Liddelow, Shane A; Martin-Peña, Alfonso; Orr, Anna G; Quintana, Francisco J; Ramey, Grace D; Rexach, Jessica E; Rizzo, Stacey J S; Sexton, Claire; Tang, Alice S; Torrellas, Jose G; Tsai, Andy P; van Olst, Lynn; Walker, Keenan A; Wharton, Whitney; Tansey, Malú Gámez; Wilcock, Donna M

Alzheimer's & dementia. 2024 Dec 18;

Author Correction: Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery

Bonev, Boyan; Castelo-Branco, Gonçalo; Chen, Fei; Codeluppi, Simone; Corces, M Ryan; Fan, Jean; Heiman, Myriam; Harris, Kenneth; Inoue, Fumitaka; Kellis, Manolis; Levine, Ariel; Lotfollahi, Mo; Luo, Chongyuan; Maynard, Kristen R; Nitzan, Mor; Ramani, Vijay; Satijia, Rahul; Schirmer, Lucas; Shen, Yin; Sun, Na; Green, Gilad S; Theis, Fabian; Wang, Xiao; Welch, Joshua D; Gokce, Ozgun; Konopka, Genevieve; Liddelow, Shane; Macosko, Evan; Ali Bayraktar, Omer; Habib, Naomi; Nowakowski, Tomasz J

Nature neuroscience. 2024 Dec 16;

Neuroinflammation in Alzheimer disease

Heneka, Michael T; van der Flier, Wiesje M; Jessen, Frank; Hoozemanns, Jeroen; Thal, Dietmar Rudolf; Boche, Delphine; Brosseron, Frederic; Teunissen, Charlotte; Zetterberg, Henrik; Jacobs, Andreas H; Edison, Paul; Ramirez, Alfredo; Cruchaga, Carlos; Lambert, Jean-Charles; Laza, Agustin Ruiz; Sanchez-Mut, Jose Vicente; Fischer, Andre; Castro-Gomez, Sergio; Stein, Thor D; Kleineidam, Luca; Wagner, Michael; Neher, Jonas J; Cunningham, Colm; Singhrao, Sim K; Prinz, Marco; Glass, Christopher K; Schlachetzki, Johannes C M; Butovsky, Oleg; Kleemann, Kilian; De Jaeger, Philip L; Scheiblich, Hannah; Brown, Guy C; Landreth, Gary; Moutinho, Miguel; Grutzendler, Jaime; Gomez-Nicola, Diego; McManus, Róisín M; Andreasson, Katrin; Ising, Christina; Karabag, Deniz; Baker, Darren J; Liddelow, Shane A; Verkhratsky, Alexei; Tansey, Malu; Monsonego, Alon; Aigner, Ludwig; Dorothée, Guillaume; Nave, Klaus-Armin; Simons, Mikael; Constantin, Gabriela; Rosenzweig, Neta; Pascual, Alberto; Petzold, Gabor C; Kipnis, Jonathan; Venegas, Carmen; Colonna, Marco; Walter, Jochen; Tenner, Andrea J; O'Banion, M Kerry; Steinert, Joern R; Feinstein, Douglas L; Sastre, Magdalena; Bhaskar, Kiran; Hong, Soyon; Schafer, Dorothy P; Golde, Todd; Ransohoff, Richard M; Morgan, David; Breitner, John; Mancuso, Renzo; Riechers, Sean-Patrick

Nature reviews. Immunology. 2024 Dec 09;

See All Publications (92)

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