Shohei Koide

Shohei Koide, PhD

Perlmutter Cancer Center

Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
cancer, immunology, Protein Engineering, Protein Desgin, Cell Signaling, Structural Biology, Protein-Protein Interaction, Biologics, Drug Discovery
Summary

The central goal of our research effort is to control biology at molecular levels using synthetic proteins. A particular focus is the design and engineering of novel binding proteins. Our research is multi-disciplinary, integrating rational design, directed evolution, structural and cellular biology.

By utilizing "synthetic binding proteins" as uniquely powerful tools, we achieve high-precision control of cellular regulatory machineries, particularly those governed by allostery and/or post-translational modification, e.g. phospho-signaling, epigenetics and membrane proteins.

As Director of Cancer Biologics at the Perlmutter Cancer Center, we are developing cancer therapeutics and novel tools for cancer biology investigation.

Phone

646-501-4601

Academic office

430 East 29th Street, ACLS West Tower

Room 625

New York, NY 10016

Lab Website
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Professor, Department of Biochemistry and Molecular Pharmacology

PhD from University of Tokyo

Spencer-Smith, Russell; Koide, Akiko; Zhou, Yong; Eguchi, Raphael R; Sha, Fern; Gajwani, Priyanka; Santana, Dianicha; Gupta, Ankit; Jacobs, Miranda; Herrero-Garcia, Erika; Cobbert, Jacqueline; Lavoie, Hugo; Smith, Matthew; Rajakulendran, Thanashan; Dowdell, Evan; Okur, Mustafa Nazir; Dementieva, Irina; Sicheri, Frank; Therrien, Marc; Hancock, John F; Ikura, Mitsuhiko; Koide, Shohei; O'Bryan, John P

Nature chemical biology. 2017 Jan; 13(1):62-68

Hattori, Takamitsu; Lai, Darson; Dementieva, Irina S; Montano, Sherwin P; Kurosawa, Kohei; Zheng, Yupeng; Akin, Louesa R; Swist-Rosowska, Kalina M; Grzybowski, Adrian T; Koide, Akiko; Krajewski, Krzysztof; Strahl, Brian D; Kelleher, Neil L; Ruthenburg, Alexander J; Koide, Shohei

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2016 Feb 23; 113(8):2092-2097

Sha, Fern; Salzman, Gabriel; Gupta, Ankit; Koide, Shohei

Protein science. 2017 Mar 24; 26(5):910-924

Tanaka, Shun-Ichi; Takahashi, Tetsuya; Koide, Akiko; Ishihara, Satoru; Koikeda, Satoshi; Koide, Shohei

Nature chemical biology. 2015 Oct; 11(10):762-764

Stockbridge, Randy B; Kolmakova-Partensky, Ludmila; Shane, Tania; Koide, Akiko; Koide, Shohei; Miller, Christopher; Newstead, Simon

Nature. 2015 Sep 24; 525(7570):548-551

Diver, Melinda M; Pedi, Leanne; Koide, Akiko; Koide, Shohei; Long, Stephen B

Nature. 2018 Jan 17; 553(7689):526-529

Yasui, Norihisa; Findlay, Greg M; Gish, Gerald D; Hsiung, Marilyn S; Huang, Jin; Tucholska, Monika; Taylor, Lorne; Smith, Louis; Boldridge, W Clifford; Koide, Akiko; Pawson, Tony; Koide, Shohei

Molecular cell. 2014 Jun 19; 54(6):1034-1041

Koide, Akiko; Wojcik, John; Gilbreth, Ryan N; Hoey, Robert J; Koide, Shohei

Journal of molecular biology. 2012 Jan 13; 415(2):393-405