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Shukti Chakravarti

Shukti Chakravarti, PhD

Professor, Department of Ophthalmology

Professor, Department of Pathology

Keywords
inflammation, innate immunity, cornea, corneal disease, keratoconus genetics, extracellular matrix
Summary

SUMMARY

We are interested in understanding how the extracellular matrix (ECM) regulates cellular functions and tissue homeostasis. The ECM is a network of collagens, proteoglycans, and glycoproteins that facilitates cell communication and function in multicellular organisms. The macromolecular composition and the structure of the ECM change with the needs of the particular tissue. Importantly, in an ECM that is remodeling, the components are more readily available to interact with cells to provide instructive signals during repair and regeneration. We strive to understand dysregulations in these cell-ECM interactions that form the basis of many pathological conditions. Our work on lumican and other members of the small leucine-rich repeat proteoglycan (SLRP) family of the ECM show that in addition to regulating collagen fibril assembly, SLRPs interact with immune cells to regulate chemotaxis, phagocytosis, and toll-like receptor mediated innate immune responses in a remodeling ECM. Our ongoing work on SLRPs uses mouse models to elucidate the role of SLRPs in neutrophil, macrophage and dendritic cell functions in bacterial and viral infections.

 

A second research area in our laboratory focuses on the ECM changes and the underlying genetic causes in a corneal disease called keratoconus where there is a gradual loss in corneal cells and ECM. With progressive loss of vision and a poorly understood etiology, keratoconus is the second most common cause for corneal transplants worldwide. We are sequencing keratoconus patient DNA to identify causal genetic variants, and use cell culture and cornea organoid culture models for functional characterizations of these novel genetic variants.

Lab members

Masters Student

Nidhi Patel, BS

Postdoctoral Fellows

George Maiti, PhD 2016-

Vishal Shinde, PhD 2016-

Asim Biswas, PhD, 2020-

Research Technicians

Nan Hu, MS, 2017-

Mackenzie Charter, MS,, 2020-

Phone

646-501-8464

Academic office

430 E29th street

Alexandria Life Sciences West , 507

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Director, Basic Science Research, Department of Ophthalmology

PhD from University of Pittsburgh

Case Western Reserve University, Genetics

Shinde, Vishal; Hu, Nan; Mahale, Alka; Maiti, George; Daoud, Yassine; Eberhart, Charles G; Maktabi, Azza; Jun, Albert S; Al-Swailem, Samar A; Chakravarti, Shukti

Scientific reports. 2020 Jun 18; 10(1):9907

Mohammadzadeh, Naiyereh; Melleby, Arne Olav; Palmero, Sheryl; Sjaastad, Ivar; Chakravarti, Shukti; Engebretsen, Kristin V T; Christensen, Geir; Lunde, Ida G; Tønnessen, Theis

Cardiology. 2020 Jan 22; 1-12

Foster, James W; Wahlin, Karl J; Chakravarti, Shukti

Methods in molecular biology. 2020 Jun; 2145:51-58

Shinde, Vishal; Hu, Nan; Renuse, Santosh; Mahale, Alka; Pandey, Akhilesh; Eberhart, Charles; Stone, Donald; Al-Swailem, Samar A; Maktabi, Azza; Chakravarti, Shukti

Omics : a journal of integrative biology. 2019 Nov; 23(11):583-597

Soiberman, Uri Simcha; Shehata, Ahmed Elsayed Mahmoud; Lu, Michelle Xiaoyi; Young, Tempest; Daoud, Yassine J; Chakravarti, Shukti; Jun, Albert S; Foster, James William

Investigative ophthalmology & visual science. IOVS. 2019 Aug 01; 60(10):3422-3431

Mohammadzadeh, Naiyereh; Lunde, Ida G; Andenæs, Kine; Strand, Mari E; Aronsen, Jan Magnus; Skrbic, Biljana; Marstein, Henriette S; Bandlien, Caroline; Nygård, Ståle; Gorham, Joshua; Sjaastad, Ivar; Chakravarti, Shukti; Christensen, Geir; Engebretsen, Kristin V T; Tønnessen, Theis

Scientific reports. 2019 Jun 24; 9(1):9206

Jaiswal, Anil Kumar; Sadasivam, Mohanraj; Archer, Nathan K; Miller, Robert J; Dillen, Carly A; Ravipati, Advaitaa; Park, Pyong Woo; Chakravarti, Shukti; Miller, Lloyd S; Hamad, Abdel Rahim A

Journal of immunology (1950). 2018 Sep 15; 201(6):1651-1661

Foster, James W; Shinde, Vishal; Soiberman, Uri S; Sathe, Gajanan; Liu, Sheng; Wan, Julius; Qian, Jiang; Dauoud, Yassine; Pandey, Akhilesh; Jun, Albert S; Chakravarti, Shukti

Investigative ophthalmology & visual science. IOVS. 2018 Jun 01; 59(7):2977-2986