Shunzhi Wang

Shunzhi Wang, PhD

Institute for Systems Genetics

Assistant Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
Biomolecular self-assembly, Protein design, Delivery, Programmable therapeutics, Generative biology
Summary

We study how biomacromolecules self-organize into complex architectures and functional materials by designing new ones from scratch. Our research brings together AI-enabled biomolecular engineering, delivery technologies, and system-level generative design. By developing and applying these tools, we uncover the principles that govern emergent biological behaviors in space and time. Our goal is to translate these insights into programmable medicines that advance human health.

Academic office

45-18 Ct Square W

5th floor, 615

Long Island City, NY 11101

Lab Website
Wang Lab
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Positions

Assistant Professor, Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine

Graduate Education

PhD from Northwestern University

Postdoctoral Training

University of Washington, Seattle, David Baker

Bond-centric modular design of protein assemblies

Wang, Shunzhi; Favor, Andrew; Kibler, Ryan D; Lubner, Joshua M; Borst, Andrew J; Coudray, Nicolas; Redler, Rachel L; Chiang, Huat Thart; Sheffler, William; Hsia, Yang; Bethel, Neville P; Li, Zhe; Ekiert, Damian C; Bhabha, Gira; Pozzo, Lilo D; Baker, David

Nature materials. 2025 Oct; 24(10):1644-1652

Accurate computational design of three-dimensional protein crystals

Li, Zhe; Wang, Shunzhi; Nattermann, Una; Bera, Asim K.; Borst, Andrew J.; Yaman, Muammer Y.; Bick, Matthew J.; Yang, Erin C.; Sheffler, William; Lee, Byeongdu; Seifert, Soenke; Hura, Greg L.; Nguyen, Hannah; Kang, Alex; Dalal, Radhika; Lubner, Joshua M.; Hsia, Yang; Haddox, Hugh; Courbet, Alexis; Dowling, Quinton; Miranda, Marcos; Favor, Andrew; Etemadi, Ali; Edman, Natasha I.; Yang, Wei; Weidle, Connor; Sankaran, Banumathi; Negahdari, Babak; Ross, Michael B.; Ginger, David S.; Baker, David

Nature materials. 2023; 22(12):1556-1563

Top-down design of protein architectures with reinforcement learning

Lutz, Isaac D; Wang, Shunzhi; Norn, Christoffer; Courbet, Alexis; Borst, Andrew J; Zhao, Yan Ting; Dosey, Annie; Cao, Longxing; Xu, Jinwei; Leaf, Elizabeth M; Treichel, Catherine; Litvicov, Patrisia; Li, Zhe; Goodson, Alexander D; Rivera-Sánchez, Paula; Bratovianu, Ana-Maria; Baek, Minkyung; King, Neil P; Ruohola-Baker, Hannele; Baker, David

Science. 2023 Apr 21; 380(6642):266-273

Exploration of Structured Symmetric Cyclic Peptides as Ligands for Metal-Organic Frameworks

Said, Meerit Y; Kang, Christine S; Wang, Shunzhi; Sheffler, William; Salveson, Patrick J; Bera, Asim K; Kang, Alex; Nguyen, Hannah; Ballard, Ryanne; Li, Xinting; Bai, Hua; Stewart, Lance; Levine, Paul; Baker, David

Chemistry of materials. 2022 Nov 08; 34(21):9736-9744

Precision materials: Computational design methods of accurate protein materials

Wang, Shunzhi; Ben-Sasson, Ariel J

Current opinion in structural biology. 2022 Jun; 74:102367

The emergence of valency in colloidal crystals through electron equivalents

Wang, Shunzhi; Lee, Sangmin; Du, Jingshan S; Partridge, Benjamin E; Cheng, Ho Fung; Zhou, Wenjie; Dravid, Vinayak P; Lee, Byeongdu; Glotzer, Sharon C; Mirkin, Chad A

Nature materials. 2022 May; 21(5):580-587

Electron-Equivalent Valency through Molecularly Well-Defined Multivalent DNA

Cheng, Ho Fung; Wang, Shunzhi; Mirkin, Chad A

Journal of the American Chemical Society. 2021 Feb 03; 143(4):1752-1757

Colloidal crystal engineering with metal-organic framework nanoparticles and DNA

Wang, Shunzhi; Park, Sarah S; Buru, Cassandra T; Lin, Haixin; Chen, Peng-Cheng; Roth, Eric W; Farha, Omar K; Mirkin, Chad A

Nature communications. 2020 May 19; 11(1):2495

See All Publications (21)