Stan Colcombe, PhD

Research Associate Professor, Department of Psychiatry

Keywords
Neurocognitive Aging, Brain Plasticity, Cognitive Function, Autonomic Markers, Exercise and Brain Health
Summary

My primary research focus is on neurocognitive aging and brain plasticity. This line of work aims to understand why our brains become less adaptable as we age - and to identify mechanisms that can help offset or reverse these changes.

In my earlier work, my colleagues and I published the first studies demonstrating that cardiovascular exercise in older adults (65+ years) can lead to:

            •           Improved cognitive performance (measured via laboratory-based cognitive tasks)

            •           Increased brain volume (measured via structural MRI)

            •           Brain activity patterns resembling those of younger adults (measured via functional MRI)

These findings have since been widely replicated in various contexts, including:

            •           Normal aging and Mild Cognitive Impairment

            •           Neurodegenerative diseases

            •           Psychiatric conditions

            •           Childhood development

More recently, I have expanded this work to examine how brain and behavioral changes relate to individual differences in metabolic and physiological markers across the lifespan. One of the more exciting current approaches focuses on understanding how rapid, moment-by-moment physiological changes correspond to momentary changes in behavioral adaptation. To address this, we have developed novel methods and approaches that enable:

            •           Simultaneous measurement of physiology and behavior at high sampling rates (30+ times per second)

            •           Analysis of dynamic relationships between brain function, behavior, and immediate physiological fluctuations

Preliminary results from these studies suggest a complex and dynamic relationship between these systems, offering new insights into how the brain adapts (or fails to adapt) to changing cognitive demands.

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Positions

Research Associate Professor, Department of Psychiatry at NYU Grossman School of Medicine

Graduate Education

PhD from University of Illinois College of Medicine

Residency And Fellowship Training

Fellowship, The Beckman Institute, Neuroscience

Connectome-based symptom mapping and in silico related gene expression in children with autism and/or attention-deficit/hyperactivity disorder

Segura, Patricia; Pagani, Marco; Bishop, Somer L; Thomson, Phoebe; Colcombe, Stanley; Xu, Ting; Factor, Zekiel Z; Hector, Emily C; Kim, So Hyun; Lombardo, Michael V; Gozzi, Alessandro; Castellanos, Xavier F; Lord, Catherine; Milham, Michael P; Martino, Adriana Di

[Zhong ji yi kan] = [Medicine for intermediate groups]. 2024 Dec 11;

Age, Motion, Medical, and Psychiatric Associations With Incidental Findings in Brain MRI

Tobe, Russell H; Tu, Lucia; Roberts, Maya; Kiar, Gregory; Breland, Melissa M; Tian, Yiwen; Kang, Minji; Ross, Rachel; Ryan, Margaret M; Valenza, Emmanuel; Alexander, Lindsay; MacKay-Brandt, Anna; Colcombe, Stanley J; Franco, Alexandre R; Milham, Michael P

JAMA network open. 2024 Feb 05; 7(2):e2355901

An open-access dataset of naturalistic viewing using simultaneous EEG-fMRI

Telesford, Qawi K; Gonzalez-Moreira, Eduardo; Xu, Ting; Tian, Yiwen; Colcombe, Stanley J; Cloud, Jessica; Russ, Brian E; Falchier, Arnaud; Nentwich, Maximilian; Madsen, Jens; Parra, Lucas C; Schroeder, Charles E; Milham, Michael P; Franco, Alexandre R

Scientific data. 2023 Aug 23; 10(1):554

Specific and common functional connectivity deficits in drug-free generalized anxiety disorder and panic disorder: A data-driven analysis

Li, Wei; Cui, Huiru; Li, Hui; Colcombe, Stan; Smith, Robert C; Cao, Xinyi; Pang, Jiaoyan; Hu, Qiang; Zhang, Lanlan; Yang, Zhi; Wang, Jijun; Li, Chunbo

Psychiatry research. 2022 Nov 21; 319:114971

A longitudinal resource for studying connectome development and its psychiatric associations during childhood

Tobe, Russell H; MacKay-Brandt, Anna; Lim, Ryan; Kramer, Melissa; Breland, Melissa M; Tu, Lucia; Tian, Yiwen; Trautman, Kristin Dietz; Hu, Caixia; Sangoi, Raj; Alexander, Lindsay; Gabbay, Vilma; Castellanos, F Xavier; Leventhal, Bennett L; Craddock, R Cameron; Colcombe, Stanley J; Franco, Alexandre R; Milham, Michael P

Scientific data. 2022 06 14; 9(1):300

Toward next-generation primate neuroscience: A collaboration-based strategic plan for integrative neuroimaging

Milham, Michael; Petkov, Chris; Belin, Pascal; Ben Hamed, Suliann; Evrard, Henry; Fair, Damien; Fox, Andrew; Froudist-Walsh, Sean; Hayashi, Takuya; Kastner, Sabine; Klink, Chris; Majka, Piotr; Mars, Rogier; Messinger, Adam; Poirier, Colline; Schroeder, Charles; Shmuel, Amir; Silva, Afonso C; Vanduffel, Wim; Van Essen, David C; Wang, Zheng; Roe, Anna Wang; Wilke, Melanie; Xu, Ting; Aarabi, Mohammad Hadi; Adolphs, Ralph; Ahuja, Aarit; Alvand, Ashkan; Amiez, Celine; Autio, Joonas; Azadi, Reza; Baeg, Eunha; Bai, Ruiliang; Bao, Pinglei; Basso, Michele; Behel, Austin K; Bennett, Yvonne; Bernhardt, Boris; Biswal, Bharat; Boopathy, Sethu; Boretius, Susann; Borra, Elena; Boshra, Rober; Buffalo, Elizabeth; Cao, Long; Cavanaugh, James; Celine, Amiez; Chavez, Gianfranco; Chen, Li Min; Chen, Xiaodong; Cheng, Luqi; Chouinard-Decorte, Francois; Clavagnier, Simon; Cléry, Justine; Colcombe, Stan J; Conway, Bevil; Cordeau, Melina; Coulon, Olivier; Cui, Yue; Dadarwal, Rakshit; Dahnke, Robert; Desrochers, Theresa; Deying, Li; Dougherty, Kacie; Doyle, Hannah; Drzewiecki, Carly M; Duyck, Marianne; Arachchi, Wasana Ediri; Elorette, Catherine; Essamlali, Abdelhadi; Evans, Alan; Fajardo, Alfonso; Figueroa, Hector; Franco, Alexandre; Freches, Guilherme; Frey, Steve; Friedrich, Patrick; Fujimoto, Atsushi; Fukunaga, Masaki; Gacoin, Maeva; Gallardo, Guillermo; Gao, Lixia; Gao, Yang; Garside, Danny; Garza-Villarreal, Eduardo A; Gaudet-Trafit, Maxime; Gerbella, Marzio; Giavasis, Steven; Glen, Daniel; Ribeiro Gomes, Ana Rita; Torrecilla, Sandra Gonzalez; Gozzi, Alessandro; Gulli, Roberto; Haber, Suzanne; Hadj-Bouziane, Fadila; Fujimoto, Satoka Hashimoto; Hawrylycz, Michael; He, Quansheng; He, Ye; Heuer, Katja; Hiba, Bassem; Hoffstaedter, Felix; Hong, Seok-Jun; Hori, Yuki; Hou, Yujie; Howard, Amy; de la Iglesia-Vaya, Maria; Ikeda, Takuro; Jankovic-Rapan, Lucija; Jaramillo, Jorge; Jedema, Hank P; Jin, Hecheng; Jiang, Minqing; Jung, Benjamin; Kagan, Igor; Kahn, Itamar; Kiar, Gregory; Kikuchi, Yuki; Kilavik, Bjørg; Kimura, Nobuyuki; Klatzmann, Ulysse; Kwok, Sze Chai; Lai, Hsin-Yi; Lamberton, Franck; Lehman, Julia; Li, Pengcheng; Li, Xinhui; Li, Xinjian; Liang, Zhifeng; Liston, Conor; Little, Roger; Liu, Cirong; Liu, Ning; Liu, Xiaojin; Liu, Xinyu; Lu, Haidong; Loh, Kep Kee; Madan, Christopher; Magrou, Loïc; Margulies, Daniel; Mathilda, Froesel; Mejia, Sheyla; Meng, Yao; Menon, Ravi; Meunier, David; Mitchell, A J; Mitchell, Anna; Murphy, Aidan; Mvula, Towela; Ortiz-Rios, Michael; Ortuzar Martinez, Diego Emanuel; Pagani, Marco; Palomero-Gallagher, Nicola; Pareek, Vikas; Perkins, Pierce; Ponce, Fernanda; Postans, Mark; Pouget, Pierre; Qian, Meizhen; Ramirez, Julian Bene; Raven, Erika; Restrepo, Isabel; Rima, Samy; Rockland, Kathleen; Rodriguez, Nadira Yusif; Roger, Elise; Hortelano, Eduardo Rojas; Rosa, Marcello; Rossi, Andrew; Rudebeck, Peter; Russ, Brian; Sakai, Tomoko; Saleem, Kadharbatcha S; Sallet, Jerome; Sawiak, Stephen; Schaeffer, David; Schwiedrzik, Caspar M; Seidlitz, Jakob; Sein, Julien; Sharma, Jitendra; Shen, Kelly; Sheng, Wei-An; Shi, Neo Sunhang; Shim, Won Mok; Simone, Luciano; Sirmpilatze, Nikoloz; Sivan, Virginie; Song, Xiaowei; Tanenbaum, Aaron; Tasserie, Jordy; Taylor, Paul; Tian, Xiaoguang; Toro, Roberto; Trambaiolli, Lucas; Upright, Nick; Vezoli, Julien; Vickery, Sam; Villalon, Julio; Wang, Xiaojie; Wang, Yufan; Weiss, Alison R; Wilson, Charlie; Wong, Ting-Yat; Woo, Choong-Wan; Wu, Bichan; Xiao, Du; Xu, Augix Guohua; Xu, Dongrong; Xufeng, Zhou; Yacoub, Essa; Ye, Ningrong; Ying, Zhang; Yokoyama, Chihiro; Yu, Xiongjie; Yue, Shasha; Yuheng, Lu; Yumeng, Xin; Zaldivar, Daniel; Zhang, Shaomin; Zhao, Yuguang; Zuo, Zhanguang

Neuron. 2022 Jan 05; 110(1):16-20

Predicting multiscan MRI outcomes in children with neurodevelopmental conditions following MRI simulator training

Simhal, Anish K; Filho, José O A; Segura, Patricia; Cloud, Jessica; Petkova, Eva; Gallagher, Richard; Castellanos, F Xavier; Colcombe, Stan; Milham, Michael P; Di Martino, Adriana

Developmental cognitive neuroscience. 2021 Sep 16; 52:101009

Is it time to switch your T1W sequence? Assessing the impact of prospective motion correction on the reliability and quality of structural imaging

Ai, Lei; Craddock, R Cameron; Tottenham, Nim; Dyke, Jonathan P; Lim, Ryan; Colcombe, Stanley; Milham, Michael; Franco, Alexandre R

Neuroimage. 2020 Nov 26; 226:117585

See All Publications (99)