Jeffrey Bergstein Professor of Medicine, Department of Pathology
The research in my lab focuses on signaling pathways in cells of the immune system, particularly store-operated calcium entry (SOCE), mediated by the calcium release–activated calcium (CRAC) channel, and other ion channels that control immune cell function.
We are investigating how CRAC channels are activated, how they affect cell physiology, and how calcium signals control immune function in the contexts of infection, autoimmunity, and cancer. To this end, we are studying animal models and patients with defects in CRAC channel function. Besides calcium channels, the lab is characterizing a variety of other ion channel pathways in immune cell function in health and disease.
Fellowship, Harvard University, Postdoctoral training, Immune Disease Institute
Residency, University of Freiburg (Germany), Rheumatology
Nature communications. 2017 03 15; 8:14714
Cell metabolism. 2017 03 07; 25(3):698-712
Journal of clinical investigation. 2016 11 01; 126(11):4303-4318
Immunity. 2016 06 21; 44(6):1350-64
Journal of immunology (1950). 2016 Jan 15; 196(2):573-85
Annals of the New York Academy of Sciences. 2015 Nov; 1356:45-79
Journal of clinical investigation. 2015 Jun; 125(6):2347-62
Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 May 12; 112(19):6206-11