The research in my lab focuses on signaling pathways in cells of the immune system, particularly store-operated calcium entry (SOCE), mediated by the calcium release–activated calcium (CRAC) channel, and other ion channels.
We are investigating how CRAC channels are activated, how they affect cell physiology, and how calcium signals control immune function in the contexts of infection, autoimmunity, and cancer.
We are also studying patients with inherited mutations in CRAC channel genes. We use mouse models with targeted deletions of CRAC channel genes and employ genetic screening to identify ion channels that control immune responses in health and disease.
Associate Professor, Department of Pathology
Fellowship, Harvard University, Postdoctoral training, Immune Disease Institute
Residency, University of Freiburg (Germany), Rheumatology
Nature communications. 2017 Mar 15; 8:14714-14714
Cell metabolism. 2017 Jan 26; 25(3):698-712
Journal of clinical investigation. 2016 Nov 01; 126(11):4303-4318
Immunity. 2016 Jun 21; 44(6):1350-1364
Journal of immunology (1950). 2016 Jan 15; 196(2):573-585
Annals of the New York Academy of Sciences. 2015 Nov; 1356:45-79
Journal of clinical investigation. 2015 Jun; 125(6):2347-2362
Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 May 12; 112(19):6206-6211