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Stefan Feske

Stefan Feske, MD

Jeffrey Bergstein Professor of Medicine, Department of Pathology

Keywords
Immunology, Immunity to Infection, Autoimmunity, Primary Immunodeficiency, Ion Channels and Transporters, Calcium Channels, Cell Physiology
Summary

The research in my lab focuses on signaling pathways in cells of the immune system, particularly store-operated calcium entry (SOCE), mediated by the calcium release–activated calcium (CRAC) channel, and other ion channels that control immune cell function.

We are investigating how CRAC channels are activated, how they affect cell physiology, and how calcium signals control immune function in the contexts of infection, autoimmunity, and cancer. To this end, we are studying animal models and patients with defects in CRAC channel function. Besides calcium channels, the lab is characterizing a variety of other ion channel pathways in immune cell function in health and disease.

Phone

212-263-9066

Academic office

550 First Avenue, Smilow Research Building

510

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Jeffrey Bergstein Professor of Medicine, Department of Pathology

Fellowship, Harvard University, Postdoctoral training, Immune Disease Institute

Residency, University of Freiburg (Germany), Rheumatology

Vaeth, Martin; Yang, Jun; Yamashita, Megumi; Zee, Isabelle; Eckstein, Miriam; Knosp, Camille; Kaufmann, Ulrike; Karoly Jani, Peter; Lacruz, Rodrigo S; Flockerzi, Veit; Kacskovics, Imre; Prakriya, Murali; Feske, Stefan

Nature communications. 2017 03 15; 8:14714

Maus, Mate; Cuk, Mario; Patel, Bindi; Lian, Jayson; Ouimet, Mireille; Kaufmann, Ulrike; Yang, Jun; Horvath, Rita; Hornig-Do, Hue-Tran; Chrzanowska-Lightowlers, Zofia M; Moore, Kathryn J; Cuervo, Ana Maria; Feske, Stefan

Cell metabolism. 2017 03 07; 25(3):698-712

Concepcion, Axel R; Vaeth, Martin; Wagner, Larry E 2nd; Eckstein, Miriam; Hecht, Lee; Yang, Jun; Crottes, David; Seidl, Maximilian; Shin, Hyosup P; Weidinger, Carl; Cameron, Scott; Turvey, Stuart E; Issekutz, Thomas; Meyts, Isabelle; Lacruz, Rodrigo S; Cuk, Mario; Yule, David I; Feske, Stefan

Journal of clinical investigation. 2016 11 01; 126(11):4303-4318

Vaeth, Martin; Eckstein, Miriam; Shaw, Patrick J; Kozhaya, Lina; Yang, Jun; Berberich-Siebelt, Friederike; Clancy, Robert; Unutmaz, Derya; Feske, Stefan

Immunity. 2016 06 21; 44(6):1350-64

Kaufmann, Ulrike; Shaw, Patrick J; Kozhaya, Lina; Subramanian, Raju; Gaida, Kevin; Unutmaz, Derya; McBride, Helen J; Feske, Stefan

Journal of immunology (1950). 2016 Jan 15; 196(2):573-85

Lacruz, Rodrigo S; Feske, Stefan

Annals of the New York Academy of Sciences. 2015 Nov; 1356:45-79

Desvignes, Ludovic; Weidinger, Carl; Shaw, Patrick; Vaeth, Martin; Ribierre, Theo; Liu, Menghan; Fergus, Tawania; Kozhaya, Lina; McVoy, Lauren; Unutmaz, Derya; Ernst, Joel D; Feske, Stefan

Journal of clinical investigation. 2015 Jun; 125(6):2347-62

Maus, Mate; Jairaman, Amit; Stathopulos, Peter B; Muik, Martin; Fahrner, Marc; Weidinger, Carl; Benson, Melina; Fuchs, Sebastian; Ehl, Stephan; Romanin, Christoph; Ikura, Mitsuhiko; Prakriya, Murali; Feske, Stefan

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 May 12; 112(19):6206-11