Stefan Feske

Stefan Feske, MD

Associate Professor, Department of Pathology

Immunology, Immunity to infection, Autoimmunity, Primary Immundeficiency, Ion channels and transporters, Calcium channels, Cell Physiology

My lab's research is focused on signaling pathways in cells of the immune system, particularly store-operated calcium entry (SOCE) and CRAC calcium channel function. We are investigating the mechanisms of CRAC channel activation, how CRAC channels affect cell physiology and how calcium signals control immune function in the context of infection, autoimmunity and cancer. We are studying patients with inherited mutations in CRAC channel genes, use mice with targeted deletion of CRAC channel genes and employ genetic screens to identify ion channels that control immune responses in health and disease. 

For more information on research in the Feske lab, please refer to:



Academic office

550 First Avenue, Smilow Research Building


New York, NY 10016

Lab Website
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Associate Professor, Department of Pathology

Fellowship, Harvard University, Postdoctoral training, Immune Disease Institute

Residency, University of Freiburg (Germany), Rheumatology

Vaeth, Martin; Yang, Jun; Yamashita, Megumi; Zee, Isabelle; Eckstein, Miriam; Knosp, Camille; Kaufmann, Ulrike; Karoly Jani, Peter; Lacruz, Rodrigo S; Flockerzi, Veit; Kacskovics, Imre; Prakriya, Murali; Feske, Stefan

Nature communications. 2017 Mar 15; 8:14714-14714

Maus, Mate; Cuk, Mario; Patel, Bindi; Lian, Jayson; Ouimet, Mireille; Kaufmann, Ulrike; Yang, Jun; Horvath, Rita; Hornig-Do, Hue-Tran; Chrzanowska-Lightowlers, Zofia M; Moore, Kathryn J; Cuervo, Ana Maria; Feske, Stefan

Cell metabolism. 2017 Jan 26; 25(3):698-712

Concepcion, Axel R; Vaeth, Martin; Wagner, Larry E 2nd; Eckstein, Miriam; Hecht, Lee; Yang, Jun; Crottes, David; Seidl, Maximilian; Shin, Hyosup P; Weidinger, Carl; Cameron, Scott; Turvey, Stuart E; Issekutz, Thomas; Meyts, Isabelle; Lacruz, Rodrigo S; Cuk, Mario; Yule, David I; Feske, Stefan

Journal of clinical investigation. 2016 Nov 01; 126(11):4303-4318

Vaeth, Martin; Eckstein, Miriam; Shaw, Patrick J; Kozhaya, Lina; Yang, Jun; Berberich-Siebelt, Friederike; Clancy, Robert; Unutmaz, Derya; Feske, Stefan

Immunity. 2016 Jun 21; 44(6):1350-1364

Kaufmann, Ulrike; Shaw, Patrick J; Kozhaya, Lina; Subramanian, Raju; Gaida, Kevin; Unutmaz, Derya; McBride, Helen J; Feske, Stefan

Journal of immunology (1950). 2016 Jan 15; 196(2):573-585

Lacruz, Rodrigo S; Feske, Stefan

Annals of the New York Academy of Sciences. 2015 Nov; 1356:45-79

Desvignes, Ludovic; Weidinger, Carl; Shaw, Patrick; Vaeth, Martin; Ribierre, Theo; Liu, Menghan; Fergus, Tawania; Kozhaya, Lina; McVoy, Lauren; Unutmaz, Derya; Ernst, Joel D; Feske, Stefan

Journal of clinical investigation. 2015 Jun; 125(6):2347-2362

Maus, Mate; Jairaman, Amit; Stathopulos, Peter B; Muik, Martin; Fahrner, Marc; Weidinger, Carl; Benson, Melina; Fuchs, Sebastian; Ehl, Stephan; Romanin, Christoph; Ikura, Mitsuhiko; Prakriya, Murali; Feske, Stefan

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 May 12; 112(19):6206-6211