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Stevan R. Hubbard

Stevan R. Hubbard, PhD

Adjunct Professor, Department of Biochemistry and Molecular Pharmacology

Protein tyrosine kinases, Insulin receptor, Janus kinases, Tyrosine phosphorylation, Histidine phosphorylation, X-ray crystallography, Biophysics

My laboratory is interested in the molecular mechanisms by which the insulin receptor and other receptor tyrosine kinases (RTKs) are activated upon ligand binding, and the structural basis for recruitment of downstream signaling proteins to activated receptors. The main experimental technique we employ for three-dimensional structure determination is x-ray crystallography. Members of the RTK family include, among others, the insulin and insulin-like growth factor-1 (IGF1) receptors, fibroblast growth factor receptor, platelet-derived growth factor receptor, and epidermal growth factor receptor. RTKs play critical roles in signal transduction pathways that mediate cell proliferation, differentiation, migration and metabolism, both in organismal development and in adult homeostasis. RTKs have also been implicated in the onset or progression of numerous cancers. We are also studying the molecular mechanisms by which JAK2, a member of the Janus kinase family of non-receptor tyrosine kinases, is regulated. Activating mutations in JAK2 are causative for myeloproliferative neoplasms in humans. Finally, in collaboration with Dr. Edward Skolnik at  NYU School of Medicine, we have been investigating the molecular mechanisms by which the potassium channel KCa3.1 is activating by calcium binding and histidine phosphorylation.



Academic office

540 First Avenue, Skirball Institute

3, 14

New York, NY 10016

Lab Website
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PhD from Stanford University

Srivastava, Shekhar; Panda, Saswati; Li, Zhai; Fuhs, Stephen R; Hunter, Tony; Thiele, Dennis J; Hubbard, Stevan R; Skolnik, Edward Y

eLife. 2016 Aug 19; 5:

Hammaren, Henrik M; Ungureanu, Daniela; Grisouard, Jean; Skoda, Radek C; Hubbard, Stevan R; Silvennoinen, Olli

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 Apr 14; 112(15):4642-7

Silvennoinen, Olli; Hubbard, Stevan R

Blood. 2015 May 28; 125(22):3388-92

Cabail, M Zulema; Li, Shiqing; Lemmon, Eric; Bowen, Mark E; Hubbard, Stevan R; Miller, W Todd

Nature communications. 2015 Mar 11; 6:6406

Shan, Yibing; Gnanasambandan, Kavitha; Ungureanu, Daniela; Kim, Eric T; Hammaren, Henrik; Yamashita, Kazuo; Silvennoinen, Olli; Shaw, David E; Hubbard, Stevan R

Nature structural & molecular biology. 2014 Jul; 21(7):579-84

Wynne, Joseph P; Wu, Jinhua; Su, Wenjuan; Mor, Adam; Patsoukis, Nikolaos; Boussiotis, Vassiliki A; Hubbard, Stevan R; Philips, Mark R

Journal of cell biology. 2012 Oct 15; 199(2):317-30

Bandaranayake, Rajintha M; Ungureanu, Daniela; Shan, Yibing; Shaw, David E; Silvennoinen, Olli; Hubbard, Stevan R

Nature structural & molecular biology. 2012 Aug; 19(8):754-9