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Sumantra Chatterjee

Sumantra Chatterjee

Research Assistant Professor, Department of Neuroscience and Physiology

Congenital Neuropathies, Single Cell Genomics, Enteric Nervous System,

My lab focuses on neurodevelopmental neurocristopathies in the central and autonomic nervous systems. We study Hirschsprung disease (HSCR), which affects the enteric nervous system, familial dysautonomia (FD) which affects the peripheral nervous system, and Mowat-Wilson syndrome (MWS), which affects tissues of the central nervous system. Many patients with FD and MWS also present with HSCR, suggesting that in certain cases the pathways affected in these diverse disorders converge. We aim to further the understanding of these disorders by focusing on three broad themes:

  • Genetic diversity of neurocristopathies: We use whole genome and whole exome sequencing.
  • Connecting cell type specific responses across neuronal neurocristopathies: To gain a more in-depth understanding of the effects of known disease variants during nervous system development, we are deriving enteric neurons from hESCs and patient iPSCs in order to catalog the cellular defects due to patient specific mutations. This will allow us to explain the phenotypic diversity seen in the ENS in these patients.
  • Cellular therapeutics: Due to their unique multipotency and developmental plasticity, there is a broad interest in capturing the regenerative capacity of neural crest cells via stem cell-based treatments. We use CRISPR-based approaches to repair patient specific mutations in iPSCs to improve phenotypic outcomes.
Academic office

435 E 30th Street

10, 1012

New York, NY 10010

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Johns Hopkins University School of Medicine, Aravinda Chakravarti Lab

Chatterjee, Sumantra; Fries, Lauren E; Yaacov, Or; Hu, Nan; Berk-Rauch, Hanna E; Chakravarti, Aravinda

PLoS genetics. 2023 Nov; 19(11):e1011030

Vincent, Elizabeth; Chatterjee, Sumantra; Cannon, Gabrielle H; Auer, Dallas; Ross, Holly; Chakravarti, Aravinda; Goff, Loyal A

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2023 Aug 22; 120(34):e2211986120

Chatterjee, Sumantra; Karasaki, Kameko M; Fries, Lauren E; Kapoor, Ashish; Chakravarti, Aravinda

Genome research. 2021 Nov 15; 31(12):2199-208

Padhi, Evin M; Hayeck, Tristan J; Cheng, Zhang; Chatterjee, Sumantra; Mannion, Brandon J; Byrska-Bishop, Marta; Willems, Marjolaine; Pinson, Lucile; Redon, Sylvia; Benech, Caroline; Uguen, Kevin; Audebert-Bellanger, Séverine; Le Marechal, Cédric; Férec, Claude; Efthymiou, Stephanie; Rahman, Fatima; Maqbool, Shazia; Maroofian, Reza; Houlden, Henry; Musunuri, Rajeeva; Narzisi, Giuseppe; Abhyankar, Avinash; Hunter, Riana D; Akiyama, Jennifer; Fries, Lauren E; Ng, Jeffrey K; Mehinovic, Elvisa; Stong, Nick; Allen, Andrew S; Dickel, Diane E; Bernier, Raphael A; Gorkin, David U; Pennacchio, Len A; Zody, Michael C; Turner, Tychele N

Human genomics. 2021 Jul 13; 15(1):44

Chatterjee, Sumantra; Nandakumar, Priyanka; Auer, Dallas R; Gabriel, Stacey B; Chakravarti, Aravinda

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2019 Dec 09; 116(52):26697-708

Chatterjee, Sumantra; Chakravarti, Aravinda

Human molecular genetics. 2019 Sep 15; 28(18):3137-3147

Tilghman, Joseph M; Ling, Albee Y; Turner, Tychele N; Sosa, Maria X; Krumm, Niklas; Chatterjee, Sumantra; Kapoor, Ashish; Coe, Bradley P; Nguyen, Khanh-Dung H; Gupta, Namrata; Gabriel, Stacey; Eichler, Evan E; Berrios, Courtney; Chakravarti, Aravinda

New England journal of medicine. 2019 Apr 11; 380(15):1421-1432

Fadista, João; Lund, Marie; Skotte, Line; Geller, Frank; Nandakumar, Priyanka; Chatterjee, Sumantra; Matsson, Hans; Granström, Anna Löf; Wester, Tomas; Salo, Perttu; Virtanen, Valtter; Carstensen, Lisbeth; Bybjerg-Grauholm, Jonas; Hougaard, David Michael; Pakarinen, Mikko; Perola, Markus; Nordenskjöld, Agneta; Chakravarti, Aravinda; Melbye, Mads; Feenstra, Bjarke

European journal of human genetics. 2018 04; 26(4):561-569