Suresh Cuddapah

Suresh Cuddapah, PhD

Assistant Professor, Department of Environmental Medicine

Assistant Professor, Department of Biochemistry and Molecular Pharmacology

epigenetic regulation of chromatin structure and gene expression

The eukaryotic genome is organized into higher order chromatin structures. The structure of chromatin and DNA accessibility is regulated, in part, by epigenetic features such as DNA methylation and histone modifications. The goal of our research is to understand the epigenetic regulation of chromatin structure and gene expression programs during differentiation and disease manifestation. We are particularly interested in understanding the causes for aberrant silencing of tumor suppressor genes, which contribute to malignancies. Understanding how and why certain genes are turned off will help unravel the disease mechanism. Aberration in the chromatin structure is one of the causes for mis-regulation of gene expression. Currently, we are investigating the role of transcription factors and epigenetic features of the genome that are involved in maintaining normal chromatin architecture and the anomalies that lead to aberrant gene silencing. In addition, we are also interested in understanding the alterations in epigenetic regulation due to pathogenesis, which in turn may favor disease progression.



Academic office

57 Old Forge Rd.

Second Floor

Tuxedo, NY 10987

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Assistant Professor, Department of Environmental Medicine

Assistant Professor, Department of Biochemistry and Molecular Pharmacology

PhD from Mysore University

Barski, Artem; Cuddapah, Suresh; Kartashov, Andrey V; Liu, Chong; Imamichi, Hiromi; Yang, Wenjing; Peng, Weiqun; Lane, H Clifford; Zhao, Keji

Scientific reports. 2017 Jan 05; 7:39785-39785

Crompton, Joseph G; Narayanan, Manikandan; Cuddapah, Suresh; Roychoudhuri, Rahul; Ji, Yun; Yang, Wenjing; Patel, Shashank J; Sukumar, Madhusudhanan; Palmer, Douglas C; Peng, Weiqun; Wang, Ena; Marincola, Francesco M; Klebanoff, Christopher A; Zhao, Keji; Tsang, John S; Gattinoni, Luca; Restifo, Nicholas P

Cellular & molecular immunology. 2016 Jul; 13(4):502-513

Jagannathan, Lakshmanan; Jose, Cynthia C; Arita, Adriana; Kluz, Thomas; Sun, Hong; Zhang, Xiaoru; Yao, Yixin; Kartashov, Andrey V; Barski, Artem; Costa, Max; Cuddapah, Suresh

Journal of cellular physiology. 2016 Jul; 231(7):1611-1620

Jagannathan, Lakshmanan; Cuddapah, Suresh; Costa, Max

Current pharmacology reports. 2016 Apr; 2(2):64-72

Jose, Cynthia C; Xu, Beisi; Jagannathan, Lakshmanan; Trac, Candi; Mallela, Ramya K; Hattori, Takamitsu; Lai, Darson; Koide, Shohei; Schones, Dustin E; Cuddapah, Suresh

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2014 Oct 07; 111(40):14631-14636

Lhoumaud, Priscillia; Hennion, Magali; Gamot, Adrien; Cuddapah, Suresh; Queille, Sophie; Liang, Jun; Micas, Gael; Morillon, Pauline; Urbach, Serge; Bouchez, Olivier; Severac, Dany; Emberly, Eldon; Zhao, Keji; Cuvier, Olivier

EMBO journal. 2014 Jul 17; 33(14):1599-1613

Liang, Jun; Lacroix, Laurent; Gamot, Adrien; Cuddapah, Suresh; Queille, Sophie; Lhoumaud, Priscillia; Lepetit, Pierre; Martin, Pascal G P; Vogelmann, Jutta; Court, Franck; Hennion, Magali; Micas, Gael; Urbach, Serge; Bouchez, Olivier; Nollmann, Marcelo; Zhao, Keji; Emberly, Eldon; Cuvier, Olivier

Molecular cell. 2014 Feb 20; 53(4):672-681

Freudenberg, Johannes M; Ghosh, Swati; Lackford, Brad L; Yellaboina, Sailu; Zheng, Xiaofeng; Li, Ruifang; Cuddapah, Suresh; Wade, Paul A; Hu, Guang; Jothi, Raja

Nucleic acids research. 2012 Apr; 40(8):3364-3377