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Suresh Cuddapah

Suresh Cuddapah, PhD

Associate Professor, Department of Environmental Medicine

Keywords
epigenetic regulation of chromatin structure and gene expression
Summary

The eukaryotic genome is organized into higher order chromatin structures. The structure of chromatin and DNA accessibility is regulated, in part, by epigenetic features such as DNA methylation and histone modifications. The goal of our research is to understand the epigenetic regulation of chromatin structure and gene expression programs during differentiation and disease manifestation. We are particularly interested in understanding the causes for aberrant silencing of tumor suppressor genes, which contribute to malignancies. Understanding how and why certain genes are turned off will help unravel the disease mechanism. Aberration in the chromatin structure is one of the causes for mis-regulation of gene expression. Currently, we are investigating the role of transcription factors and epigenetic features of the genome that are involved in maintaining normal chromatin architecture and the anomalies that lead to aberrant gene silencing. In addition, we are also interested in understanding the alterations in epigenetic regulation due to pathogenesis, which in turn may favor disease progression.

Phone

646-754-9458

Academic office

341 East 25th Street

Second Floor, 216

New York, NY 10010

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PhD from Mysore University

Jose, Cynthia C; Wang, Zhenjia; Tanwar, Vinay Singh; Zhang, Xiaoru; Zang, Chongzhi; Cuddapah, Suresh

Epigenetics & chromatin. 2019 Dec 19; 12(1):75

Tanwar, Vinay Singh; Zhang, Xiaoru; Jagannathan, Lakshmanan; Jose, Cynthia C; Cuddapah, Suresh

Toxicology & applied pharmacology. 2019 Apr 16; 373:1-9

Tanwar, Vinay Singh; Jose, Cynthia C; Cuddapah, Suresh

Mutation research. 2019 Apr - Jun; 780:61-68

Jose, Cynthia C; Jagannathan, Lakshmanan; Tanwar, Vinay Singh; Zhang, Xiaoru; Zang, Chongzhi; Cuddapah, Suresh

Molecular carcinogenesis. 2018 Jun; 57(6):794-806

Jagannathan, Lakshmanan; Jose, Cynthia C; Tanwar, Vinay Singh; Bhattacharya, Sudin; Cuddapah, Suresh

Toxicology research. 2017 May 01; 6(3):312-323

Barski, Artem; Cuddapah, Suresh; Kartashov, Andrey V; Liu, Chong; Imamichi, Hiromi; Yang, Wenjing; Peng, Weiqun; Lane, H Clifford; Zhao, Keji

Scientific reports. 2017 01 05; 7:39785

Crompton, Joseph G; Narayanan, Manikandan; Cuddapah, Suresh; Roychoudhuri, Rahul; Ji, Yun; Yang, Wenjing; Patel, Shashank J; Sukumar, Madhusudhanan; Palmer, Douglas C; Peng, Weiqun; Wang, Ena; Marincola, Francesco M; Klebanoff, Christopher A; Zhao, Keji; Tsang, John S; Gattinoni, Luca; Restifo, Nicholas P

Cellular & molecular immunology. 2016 07; 13(4):502-13

Jagannathan, Lakshmanan; Jose, Cynthia C; Arita, Adriana; Kluz, Thomas; Sun, Hong; Zhang, Xiaoru; Yao, Yixin; Kartashov, Andrey V; Barski, Artem; Costa, Max; Cuddapah, Suresh

Journal of cellular physiology. 2016 Jul; 231(7):1611-20