Susan L. Smith

Susan L. Smith, PhD

Skirball Institute

Professor, Department of Pathology

Keywords
genome integrity, cancer, aging, telomeres, sister chromatid cohesion, Poly(ADP-ribosyl)ation
Summary

Faithful duplication and segregation of DNA are essential for the continuity of life. Errors in chromosome replication and segregation can lead to aneuploidy, which can have serious consequences for human growth and development, and drive cancer in somatic cells. Telomeres, the ends of eukaryotic chromosomes, require special mechanisms for their protection, replication, and cohesion. We study human telomeres and the mechanisms that control their function in normal cells, stem cells, aging, and in cancer. Human telomere function is regulated by the dedicated six-subunit telomere-binding complex shelterin and by a number of other shelterin-binding factors, such as the poly(ADP-ribose) polymerase tankyrase 1, that associate transiently with telomeres. The focus of our research is to understand how shelterin and its accessory factors regulate telomere structure and function, control access to telomerase, and mediate sister chromatid cohesion. Our long-term goal is to understand the mechanisms that ensure genome integrity and cell survival.

Phone

212-263-2540

Fax

212-263-5711

Academic office

540 First Avenue, Skirball Institute

Second Floor, Lab 9

New York, NY 10016

Lab Website
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Professor, Department of Pathology

PhD from State University of New York at Stony Brook

Lin, Jiangguo; Countryman, Preston; Chen, Haijiang; Pan, Hai; Fan, Yanlin; Jiang, Yunyun; Kaur, Parminder; Miao, Wang; Gurgel, Gisele; You, Changjiang; Piehler, Jacob; Kad, Neil M; Riehn, Robert; Opresko, Patricia L; Smith, Susan; Tao, Yizhi Jane; Wang, Hong

Nucleic acids research. 2016 Jul 27; 44(13):6363-6376

Zhong, Linlin; Ding, Yun; Bandyopadhyay, Gautam; Waaler, Jo; Borgeson, Emma; Smith, Susan; Zhang, Mingchen; Phillips, Susan A; Mahooti, Sepi; Mahata, Sushil K; Shao, Jianhua; Krauss, Stefan; Chi, Nai-Wen

Diabetologia. 2016 Mar; 59(3):582-591

Ramamoorthy, Mahesh; Smith, Susan

Cancer cell. 2015 Sep 14; 28(3):357-369

Kim, Mi Kyung; Smith, Susan

Molecular biology of the cell. 2014 Jan; 25(1):30-40

Bisht, Kamlesh K; Daniloski, Zharko; Smith, Susan

Journal of cell science. 2013 Aug 01; 126(Pt 15):3493-3503

Bisht, Kamlesh K; Dudognon, Charles; Chang, William G; Sokol, Ethan S; Ramirez, Alejandro; Smith, Susan

Molecular & cellular biology. 2012 Aug; 32(15):3044-3053

Kim, Mi Kyung; Dudognon, Charles; Smith, Susan

EMBO reports. 2012 Aug; 13(8):724-732