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Susan L. Smith

Susan L. Smith, PhD

Professor, Department of Cell Biology

Professor, Department of Pathology

genome integrity, cancer, aging, telomeres, sister chromatid cohesion, Poly(ADP-ribosyl)ation

Faithful duplication and segregation of DNA are essential for the continuity of life. Errors in chromosome replication and segregation can lead to aneuploidy, which can have serious consequences for human growth and development, and drive cancer in somatic cells. Telomeres, the ends of eukaryotic chromosomes, require special mechanisms for their protection, replication, and cohesion. We study human telomeres and the mechanisms that control their function in normal cells, stem cells, aging, and in cancer. Human telomere function is regulated by the dedicated six-subunit telomere-binding complex shelterin and by a number of other shelterin-binding factors, such as the poly(ADP-ribose) polymerase tankyrase 1, that associate transiently with telomeres. The focus of our research is to understand how shelterin and its accessory factors regulate telomere structure and function, control access to telomerase, and mediate sister chromatid cohesion. Our long-term goal is to understand the mechanisms that ensure genome integrity and cell survival.





Academic office

540 First Avenue, Skirball Institute

Second Floor, Lab 9

New York, NY 10016

Lab Website
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PhD from State University of New York at Stony Brook

Azarm, Kameron; Bhardwaj, Amit; Kim, Eugenie; Smith, Susan

Nature communications. 2020 Jul 03; 11(1):3321

Perrard, Jerome; Smith, Susan

Nature communications. 2023 Nov 08; 14(1):7208

Sze, Samantha; Bhardwaj, Amit; Fnu, Priyanka; Azarm, Kameron; Mund, Rachel; Ring, Katherine; Smith, Susan

Cell reports. 2023 Oct 31; 42(10):113235

Lüscher, Bernhard; Ahel, Ivan; Altmeyer, Matthias; Ashworth, Alan; Bai, Peter; Chang, Paul; Cohen, Michael; Corda, Daniela; Dantzer, Françoise; Daugherty, Matthew D; Dawson, Ted M; Dawson, Valina L; Deindl, Sebastian; Fehr, Anthony R; Feijs, Karla L H; Filippov, Dmitri V; Gagné, Jean-Philippe; Grimaldi, Giovanna; Guettler, Sebastian; Hoch, Nicolas C; Hottiger, Michael O; Korn, Patricia; Kraus, W Lee; Ladurner, Andreas; Lehtiö, Lari; Leung, Anthony K L; Lord, Christopher J; Mangerich, Aswin; Matic, Ivan; Matthews, Jason; Moldovan, George-Lucian; Moss, Joel; Natoli, Gioacchino; Nielsen, Michael L; Niepel, Mario; Nolte, Friedrich; Pascal, John; Paschal, Bryce M; PawÅ‚owski, Krzysztof; Poirier, Guy G; Smith, Susan; Timinszky, Gyula; Wang, Zhao-Qi; Yélamos, José; Yu, Xiaochun; Zaja, Roko; Ziegler, Mathias

FEBS journal. 2022 Dec; 289(23):7399-7410

Azarm, Kameron; Smith, Susan

Genes & development. 2020 Mar 01; 34(5-6):285-301

Bizarro, Jonathan; Bhardwaj, Amit; Smith, Susan; Meier, U Thomas

Molecular biology of the cell. 2019 Oct 30; mbcE19080429

Daniloski, Zharko; Bisht, Kamlesh K; McStay, Brian; Smith, Susan

Genes & development. 2019 Mar 01; 33(5-6):276-281

Smith, Susan

Genes & development. 2018 05 01; 32(9-10):597-599