Takamitsu Hattori

Takamitsu Hattori, PhD

Perlmutter Cancer Center

Research Assistant Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
Antibody Design and Engineering, Drug Discovery, Affinity Reagents, Cancer, Immunotherapy, Structural Biology, Post-Translational Modifications, Protein-Protein Interaction
Summary

My research focuses on developing cancer therapeutic agents and novel molecular tools for biomedical research by designing and engineering antibodies. We employ synthetic design and a directed evolution approach to generate powerful antibodies. We engineer antibodies in various formats for developing anti-cancer drugs, including bispecific antibodies, antibody-drug conjugates (ADCs), and multivalent antibodies. We are also developing platform technology that effectively generates renewable, high-performance antibody reagents targeting challenging antigens, such as post-translational modifications, by exploiting our discovery of the unique antigen-binding mode of antibodies.

Is this your profile?
Edit profile

Positions

Research Assistant Professor, Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine

Graduate Education

PhD from Tohoku University

Binding mode-guided development of high-performance antibodies targeting site-specific posttranslational modifications

Riso, Mariapia; Shah, Rohan N; Koide, Akiko; Ruthenburg, Alexander J; Koide, Shohei; Hattori, Takamitsu

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2025 Jan 07; 122(1):e2411720121

Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain

Bang, Injin; Hattori, Takamitsu; Leloup, Nadia; Corrado, Alexis; Nyamaa, Atekana; Koide, Akiko; Geles, Ken; Buck, Elizabeth; Koide, Shohei

Nature chemical biology. 2024 Oct 22;

Molecular basis for antibody recognition of multiple drug-peptide/MHC complexes

Maso, Lorenzo; Rajak, Epsa; Bang, Injin; Koide, Akiko; Hattori, Takamitsu; Neel, Benjamin G; Koide, Shohei

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2024 May 28; 121(22):e2319029121

The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability

Ravn-Boess, Niklas; Roy, Nainita; Hattori, Takamitsu; Bready, Devin; Donaldson, Hayley; Lawson, Christopher; Lapierre, Cathryn; Korman, Aryeh; Rodrick, Tori; Liu, Enze; Frenster, Joshua D; Stephan, Gabriele; Wilcox, Jordan; Corrado, Alexis D; Cai, Julia; Ronnen, Rebecca; Wang, Shuai; Haddock, Sara; Sabio Ortiz, Jonathan; Mishkit, Orin; Khodadadi-Jamayran, Alireza; Tsirigos, Aris; Fenyö, David; Zagzag, David; Drube, Julia; Hoffmann, Carsten; Perna, Fabiana; Jones, Drew R; Possemato, Richard; Koide, Akiko; Koide, Shohei; Park, Christopher Y; Placantonakis, Dimitris G

Cell reports. 2023 Nov 28; 42(11):113374

Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors

Akkapeddi, Padma; Hattori, Takamitsu; Khan, Imran; Glasser, Eliezra; Koide, Akiko; Ketavarapu, Gayatri; Whaby, Michael; Zuberi, Mariyam; Teng, Kai Wen; Lefler, Julia; Maso, Lorenzo; Bang, Injin; Ostrowski, Michael C; O'Bryan, John P; Koide, Shohei

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2023 Jul 11; 120(28):e2302485120

In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1 -mutant lung cancer

Deng, Jiehui; Peng, David H; Fenyo, David; Yuan, Hao; Lopez, Alfonso; Levin, Daniel S; Meynardie, Mary; Quinteros, Mari; Ranieri, Michela; Sahu, Soumyadip; Lau, Sally C M; Shum, Elaine; Velcheti, Vamsidhar; Punekar, Salman R; Rekhtman, Natasha; Dowling, Catríona M; Weerasekara, Vajira; Xue, Yun; Ji, Hongbin; Siu, Yik; Jones, Drew; Hata, Aaron N; Shimamura, Takeshi; Poirier, John T; Rudin, Charles M; Hattori, Takamitsu; Koide, Shohei; Papagiannakopoulos, Thales; Neel, Benjamin G; Bardeesy, Nabeel; Wong, Kwok-Kin

bioRxiv.org : the preprint server for biology. 2023 Apr 20;

Creating MHC-restricted neoantigens with covalent inhibitors that can be targeted by immune therapy

Hattori, Takamitsu; Maso, Lorenzo; Araki, Kiyomi Y; Koide, Akiko; Hayman, James; Akkapeddi, Padma; Bang, Injin; Neel, Benjamin G; Koide, Shohei

Cancer discovery. 2023 Jan 09; 13(1):132-145

Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications

Albert, C; Bracaglia, L; Koide, A; DiRito, J; Lysyy, T; Harkins, L; Edwards, C; Richfield, O; Grundler, J; Zhou, K; Denbaum, E; Ketavarapu, G; Hattori, T; Perincheri, S; Langford, J; Feizi, A; Haakinson, D; Hosgood, S A; Nicholson, M L; Pober, J S; Saltzman, W M; Koide, S; Tietjen, G T

Nature communications. 2022 Oct 11; 13(1):5998

See All Publications (43)

Read Story