Takamitsu Hattori

Takamitsu Hattori

Perlmutter Cancer Center

Research Assistant Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
Antibody Design and Engineering, Drug Discovery, Affinity Reagents, Cancer, Immunotherapy, Structural Biology, Post-Translational Modifications, Protein-Protein Interaction
Summary

My research focuses on developing cancer therapeutic agents and novel molecular tools for biomedical research by designing and engineering antibodies. We employ synthetic design and a directed evolution approach to generate powerful antibodies. We engineer antibodies in various formats for developing anti-cancer drugs, including bispecific antibodies, antibody-drug conjugates (ADCs), and multivalent antibodies. We are also developing platform technology that effectively generates renewable, high-performance antibody reagents targeting challenging antigens, such as post-translational modifications, by exploiting our discovery of the unique antigen-binding mode of antibodies.

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Research Assistant Professor, Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine

Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain

Bang, Injin; Hattori, Takamitsu; Leloup, Nadia; Corrado, Alexis; Nyamaa, Atekana; Koide, Akiko; Geles, Ken; Buck, Elizabeth; Koide, Shohei

Nature chemical biology. 2024 Oct 22;

Molecular basis for antibody recognition of multiple drug-peptide/MHC complexes

Maso, Lorenzo; Rajak, Epsa; Bang, Injin; Koide, Akiko; Hattori, Takamitsu; Neel, Benjamin G; Koide, Shohei

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2024 May 28; 121(22):e2319029121

The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability

Ravn-Boess, Niklas; Roy, Nainita; Hattori, Takamitsu; Bready, Devin; Donaldson, Hayley; Lawson, Christopher; Lapierre, Cathryn; Korman, Aryeh; Rodrick, Tori; Liu, Enze; Frenster, Joshua D; Stephan, Gabriele; Wilcox, Jordan; Corrado, Alexis D; Cai, Julia; Ronnen, Rebecca; Wang, Shuai; Haddock, Sara; Sabio Ortiz, Jonathan; Mishkit, Orin; Khodadadi-Jamayran, Alireza; Tsirigos, Aris; Fenyö, David; Zagzag, David; Drube, Julia; Hoffmann, Carsten; Perna, Fabiana; Jones, Drew R; Possemato, Richard; Koide, Akiko; Koide, Shohei; Park, Christopher Y; Placantonakis, Dimitris G

Cell reports. 2023 Nov 28; 42(11):113374

Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors

Akkapeddi, Padma; Hattori, Takamitsu; Khan, Imran; Glasser, Eliezra; Koide, Akiko; Ketavarapu, Gayatri; Whaby, Michael; Zuberi, Mariyam; Teng, Kai Wen; Lefler, Julia; Maso, Lorenzo; Bang, Injin; Ostrowski, Michael C; O'Bryan, John P; Koide, Shohei

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2023 Jul 11; 120(28):e2302485120

In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1 -mutant lung cancer

Deng, Jiehui; Peng, David H; Fenyo, David; Yuan, Hao; Lopez, Alfonso; Levin, Daniel S; Meynardie, Mary; Quinteros, Mari; Ranieri, Michela; Sahu, Soumyadip; Lau, Sally C M; Shum, Elaine; Velcheti, Vamsidhar; Punekar, Salman R; Rekhtman, Natasha; Dowling, Catríona M; Weerasekara, Vajira; Xue, Yun; Ji, Hongbin; Siu, Yik; Jones, Drew; Hata, Aaron N; Shimamura, Takeshi; Poirier, John T; Rudin, Charles M; Hattori, Takamitsu; Koide, Shohei; Papagiannakopoulos, Thales; Neel, Benjamin G; Bardeesy, Nabeel; Wong, Kwok-Kin

bioRxiv.org : the preprint server for biology. 2023 Apr 20;

Creating MHC-restricted neoantigens with covalent inhibitors that can be targeted by immune therapy

Hattori, Takamitsu; Maso, Lorenzo; Araki, Kiyomi Y; Koide, Akiko; Hayman, James; Akkapeddi, Padma; Bang, Injin; Neel, Benjamin G; Koide, Shohei

Cancer discovery. 2023 Jan 09; 13(1):132-145

Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications

Albert, C; Bracaglia, L; Koide, A; DiRito, J; Lysyy, T; Harkins, L; Edwards, C; Richfield, O; Grundler, J; Zhou, K; Denbaum, E; Ketavarapu, G; Hattori, T; Perincheri, S; Langford, J; Feizi, A; Haakinson, D; Hosgood, S A; Nicholson, M L; Pober, J S; Saltzman, W M; Koide, S; Tietjen, G T

Nature communications. 2022 Oct 11; 13(1):5998

High-valency anti-CD99 antibodies toward the treatment of T cell acute lymphoblastic leukemia

Romero, Larizbeth A; Hattori, Takamitsu; A E Ali, Mohamed; Ketavarapu, Gayatri; Koide, Akiko; Park, Christopher Y; Koide, Shohei

Journal of molecular biology. 2021 Dec 24; 167402

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