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Tamara Wexler

Tamara Wexler, MD, PhD

Clinical Associate Professor, Department of Rehabilitation Medicine


My research interests focus on the neuroendocrine and reproductive endocrine systems, particularly on changes that may occur after traumatic brain injury (TBI).

Although there is (at last) increasing attention paid to the health effects of brain injury, there is less awareness of the role that pituitary dysfunction may play in patients’ health after TBI. Pituitary deficiencies are seen at a higher rate in patients who have suffered TBI, with some studies reporting chronic dysfunction in more than 50 percent of TBI patients.

Examples of these pituitary deficiencies include growth hormone deficiency, reproductive hormone abnormalities, centrally mediated thyroid deficiency, and adrenal insufficiency. Hypopituitarism adversely affects health and quality of life, and is associated with increased morbidity and risk of death if untreated. Diagnosis and appropriate hormone replacement can improve health and quality of life.

I established the Endocrine Patient Registry to support clinical research, as well as multidisciplinary and interinstitute research collaborations, to further investigate the importance of pituitary dysfunction and its treatment. I serve as the principal investigator of the TBI/Pituitary Registry and the lead site investigator for a multisite neuroendocrine-tumor study.

I particularly enjoy teaching about pituitary hormones, their function in the body, and how too much or too little of any hormone can affect health.

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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MD from University of Pennsylvania

PhD from University of Pennsylvania

Fellowship, The Massachusetts General Hospital, Endocrinology, Diabetes, and Metabolism

Residency, The Massachusetts General Hospital, Internal Medicine

Wexler, Tamara L

Textbook of traumatic brain injury. Washington, DC : American Psychiatric Association Publishing, [2019]. 3rd ed. p.545-562. (4452772)

Wexler, Tamara L; Durst, Ronen; McCarty, David; Picard, Michael H; Gunnell, Lindsay; Omer, Zehra; Fazeli, Pouneh; Miller, Karen K; Klibanski, Anne

Growth hormone & IGF research. 2010 Oct; 20(5):333-7

Wexler, Tamara; Gunnell, Lindsay; Omer, Zehra; Kuhlthau, Karen; Beauregard, Catherine; Graham, Gwenda; Utz, Andrea L; Biller, Beverly; Nachtigall, Lisa; Loeffler, Jay; Swearingen, Brooke; Klibanski, Anne; Miller, Karen K

Journal of clinical endocrinology & metabolism. 2009 Jul; 94(7):2471-7

Miller, Karen K; Wexler, Tamara L; Zha, Alicia M; Lawson, Elizabeth A; Meenaghan, Erinne M; Misra, Madhusmita; Binstock, Anna B; Herzog, David B; Klibanski, Anne

Journal of clinical psychiatry. 2007 Jun; 68(6):959-65

Miller, K K; Lawson, E A; Mathur, V; Wexler, T L; Meenaghan, E; Misra, M; Herzog, D B; Klibanski, A

Journal of clinical endocrinology & metabolism. 2007 Apr; 92(4):1334-9

Deschenes, S M; Walcott, J L; Wexler, T L; Scherer, S S; Fischbeck, K H

Journal of neuroscience. 1997 Dec 01; 17(23):9077-84