Professor, Department of Environmental Medicine
Our research program employs both human and animal models to study susceptibility factors—including genetics, age, and gender—underlying the adverse pulmonary and cardiac effects of environmental and occupational air pollutants. Our collaborators include several investigators at NYU Grossman School of Medicine and other academic centers.
One primary aim is to examine the cellular, molecular, and humoral interactions that lead to pollutant-induced pulmonary injury, with a focus on the contribution of genetic factors. We study the role of genetic host factors in murine models of disease, using both classic mouse genetics and computational genomics approaches.
Ambient particulate matter, which produces significant adverse cardiopulmonary effects, is another focus of the lab. Our recent research has examined the toxicity of particulate matter according to particle size, season, composition, and location (urban versus rural). We have collected ambient particulate matter in several cities in the United States, Germany, and China. Our lab also examines the role of coarse, fine, and ultrafine particulate matter in both in vitro and in vivo models.
We are currently conducting: 1) longitudinal studies on the cardiopulmonary effects of e-cigarettes in private residences in New York City; and 2) health effect studies in underground transit systems.
Fellowship, UC San Francisco, Cardiovascular Research Institute
Annual review of pharmacology & toxicology. 2022 Jan 06; 62:301-322
Environmental health perspectives. 2021 Feb; 129(2):27001
International journal of environmental research & public health. 2021 10 02; 18(19):
Particle & fibre toxicology. 2020 Jul 02; 17(1):28
Journal of travel medicine. 2019 Jun 11; 26(5):
Environmental science & technology. 2014 Dec 16; 48(24):14738-45
Environmental pollution. 2020 Dec; 267:115435