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Tessa J. Barrett

Tessa J. Barrett, PhD

Research Assistant Professor, Department of Medicine

Keywords
platelet, macrophage, monocyte, atherosclerosis, thrombosis, inflammation
Summary

My research focuses on the myeloid-platelet axis during inflammation and cardiovascular diseases.

Our laboratory studies the interaction between myeloid cells and platelets and how this axis contributes to different stages of cardiovascular disease. Our strategy is to use a complementary approach of in vivo atherosclerotic models coupled with myeloid cell and platelet phenotyping (transcriptomics, activity, immunometabolism) to elucidate the mechanisms by which the myeloid-platelet axis alters cardiovascular disease.

Platelets are critical mediators of plaque rupture and atherothrombosis. Activated platelets locally release a host of inflammatory mediators that support the chemotaxis, adhesion, and transmigration of leukocytes to sites of inflammation. Platelet activation results in an increase in circulating platelet-leukocyte aggregates, protagonists of inflammatory reactions in the vessel wall. Data from our group demonstrates an increase in monocyte-platelet aggregates (MPA) across the spectrum of cardiovascular diseases. Furthermore, in patients with lower extremity atherosclerosis, we find platelet activation to promote a proinflammatory monocyte phenotype, establishing a direct immunomodulatory role of platelets to myeloid cells in the context of vascular disease. The mechanisms which drive these interactions and their proinflammatory and functional outcomes are incompletely understood. However, both preclinically and clinically, we have found myeloid cell skewing to a proinflammatory phenotype is increased, in part, by platelet-induced IL6 signaling.

Elucidations of these mechanisms will provide novel insight into the role of the myeloid-platelet axis during health and atherosclerotic cardiovascular disease, potentially aiding in the identification a therapeutic target to modulate this interaction.

Academic office

435 East 30th St, Science Building

Seventh Floor

New York, NY 10016

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PhD from University of Sydney

New York University School of Medicine, Atherosclerosis

Barrett, Tessa J; Schlegel, Martin; Zhou, Felix; Gorenchtein, Mike; Bolstorff, Jennifer; Moore, Kathryn J; Fisher, Edward A; Berger, Jeffrey S

Science translational medicine. 2019 11 06; 11(517):

Allen, Nicole; Barrett, Tessa J; Guo, Yu; Nardi, Michael; Ramkhelawon, Bhama; Rockman, Caron B; Hochman, Judith S; Berger, Jeffrey S

Atherosclerosis. 2019 Jan 02; 282:11-18

Barrett, Tessa J; Wu, Benjamin G; Revenko, Alexey S; MacLeod, A Robert; Segal, Leopoldo N; Berger, Jeffrey S

Journal of thrombosis & haemostasis : JTH. 2020 Jul; 18(7):1773-1782

Josefs, Tatjana; Barrett, Tessa J; Brown, Emily J; Quezada, Alexandra; Wu, Xiaoyun; Voisin, Maud; Amengual, Jaume; Fisher, Edward A

JCI insight. 2020 Apr 09; 5(7):

Flynn, Michelle C; Kraakman, Michael J; Tikellis, Christos; Lee, Man Ks; Hanssen, Nordin Mj; Kammoun, Helene L; Pickering, Raelene; Dragoljevic, Dragana; Al-Sharea, Annas; Barrett, Tessa J; Hortle, Fiona; Byrne, Frances L; Olzomer, Ellen; McCarthy, Domenica A; Schalkwijk, Casper G; Forbes, Josephine M; Hoehn, Kyle; Makowski, Liza; Lancaster, Graeme I; El-Osta, Assam; Fisher, Edward A; Goldberg, Ira J; Cooper, Mark E; Nagareddy, Prabhakara R; Thomas, Merlin C; Murphy, Andrew J

Circulation research. 2020 Sep 11; 127(7):877-892

Koelwyn, Graeme J; Newman, Alexandra A C; Afonso, Milessa S; van Solingen, Coen; Corr, Emma M; Brown, Emily J; Albers, Kathleen B; Yamaguchi, Naoko; Narke, Deven; Schlegel, Martin; Sharma, Monika; Shanley, Lianne C; Barrett, Tessa J; Rahman, Karishma; Mezzano, Valeria; Fisher, Edward A; Park, David S; Newman, Jonathan D; Quail, Daniela F; Nelson, Erik R; Caan, Bette J; Jones, Lee W; Moore, Kathryn J

Nature medicine. 2020 Sep; 26(9):1452-1458

Senatus, Laura; López-Díez, Raquel; Egaña-Gorroño, Lander; Liu, Jianhua; Hu, Jiyuan; Daffu, Gurdip; Li, Qing; Rahman, Karishma; Vengrenyuk, Yuliya; Barrett, Tessa J; Dewan, M Zahidunnabi; Guo, Liang; Fuller, Daniela; Finn, Aloke V; Virmani, Renu; Li, Huilin; Friedman, Richard A; Fisher, Edward A; Ramasamy, Ravichandran; Schmidt, Ann Marie

JCI insight. 2020 Jul 09; 5(13):

Garshick, Michael S; Baumer, Yvonne; Dey, Amit K; Grattan, Ryan; Ng, Qimin; Teague, Heather L; Yu, Zu-Xi; Chen, Marcus Y; Tawil, Michael; Barrett, Tessa J; Underberg, James; Fisher, Edward A; Krueger, James; Powell-Wiley, Tiffany M; Playford, Martin P; Berger, Jeffrey S; Mehta, Nehal N

Journal of investigative dermatology. 2020 Jun 29;