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Tomas Kirchhoff, PhD

Perlmutter Cancer Center

Associate Professor, Department of Population Health

Associate Professor, Department of Environmental Medicine

Keywords
cancer, computational biology, epidemiology, genomics
Summary

The primary interest of my laboratory is focused on the identification of the genetic basis of cancer susceptibility. A key question in these efforts is how the germline genetic events contributing to predisposition of human cancers interact mutually in particular molecular pathways or in concert with the environmental exposures. Specifically, our ongoing studies aim at identification of the genetic variants conferring an increased risk to common cancers, such as breast, colon, prostate cancers or lymphoma, focusing on the relevant molecular pathways. These studies combine the genome-wide association analysis (GWAS), high-throughput genotyping and most recently the next-generation sequencing in large case/control populations. The significant aspect of my current and future research is an integration of the information from somatic genetics in tumors to complement the germline findings. We believe that such integration of biological data will be beneficial not only for improved prevention strategies but most importantly for the future development of the targeted personalized therapies.

Phone

212-263-9418

Academic office

522 First Avenue

Twelfth Floor

New York, NY 10016

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Associate Professor, Department of Population Health

Associate Professor, Department of Environmental Medicine

Memorial Sloan-Kettering Cancer Center, Clinical Cancer Genetics

Kirchhoff, Tomas; Ferguson, Robert

Methods in molecular biology. 2020 Sep; 2055:93-117

Floristán, Alfredo; Morales, Leah; Hanniford, Douglas; Martinez, Carlos; Castellano-Sanz, Elena; Dolgalev, Igor; Ulloa-Morales, Alejandro; Vega-Saenz de Miera, Eleazar; Moran, Una; Darvishian, Farbod; Osman, Iman; Kirchhoff, Tomas; Hernando, Eva

Pigment cell & melanoma research. 2019 Oct 30;

Ferguson, Robert; Archambault, Alexi; Simpson, Danny; Morales, Leah; Chat, Vylyny; Kazlow, Esther; Lax, Rebecca; Yoon, Garrett; Moran, Una; Shapiro, Richard; Pavlick, Anna; Polsky, David; Osman, Iman; Kirchhoff, Tomas

Scientific reports. 2019 Jul 15; 9(1):10173

Vallès, Yvonne; Inman, Claire K; Peters, Brandilyn A; Wareth, Laila Abdel; Abdulle, Abdishakur; Alsafar, Habiba; Anouti, Fatme Al; Dhaheri, Ayesha Al; Galani, Divya; Haji, Muna; Hamiz, Aisha Al; Hosani, Ayesha Al; Houqani, Mohammed Al; Aljunaibi, Abdulla; Kazim, Marina; Kirchhoff, Tomas; Mahmeed, Wael Al; Maskari, Fatma Al; Alnaeemi, Abdullah; Oumeziane, Naima; Ramasamy, Ravichandran; Schmidt, Ann Marie; Vallès, Henri; Zaabi, Eiman Al; Sherman, Scott; Ali, Raghib; Ahn, Jiyoung; Hayes, Richard B

Scientific reports. 2019 Jul 11; 9(1):10039

Bedognetti, Davide; Ceccarelli, Michele; Galluzzi, Lorenzo; Lu, Rongze; Palucka, Karolina; Samayoa, Josue; Spranger, Stefani; Warren, Sarah; Wong, Kwok-Kin; Ziv, Elad; Chowell, Diego; Coussens, Lisa M; De Carvalho, Daniel D; DeNardo, David G; Galon, Jérôme; Kaufman, Howard L; Kirchhoff, Tomas; Lotze, Michael T; Luke, Jason J; Minn, Andy J; Politi, Katerina; Shultz, Leonard D; Simon, Richard; Thórsson, Vésteinn; Weidhaas, Joanne B; Ascierto, Maria Libera; Ascierto, Paolo Antonio; Barnes, James M; Barsan, Valentin; Bommareddy, Praveen K; Bot, Adrian; Church, Sarah E; Ciliberto, Gennaro; De Maria, Andrea; Draganov, Dobrin; Ho, Winson S; McGee, Heather M; Monette, Anne; Murphy, Joseph F; Nisticò, Paola; Park, Wungki; Patel, Maulik; Quigley, Michael; Radvanyi, Laszlo; Raftopoulos, Harry; Rudqvist, Nils-Petter; Snyder, Alexandra; Sweis, Randy F; Valpione, Sara; Zappasodi, Roberta; Butterfield, Lisa H; Disis, Mary L; Fox, Bernard A; Cesano, Alessandra; Marincola, Francesco M

Journal for immunotherapy of cancer. 2019 Jul 04; 7(1):167

Chat, Vylyny; Ferguson, Robert; Simpson, Danny; Kazlow, Esther; Lax, Rebecca; Moran, Una; Pavlick, Anna; Frederick, Dennie; Boland, Genevieve; Sullivan, Ryan; Ribas, Antoni; Flaherty, Keith; Osman, Iman; Weber, Jeffrey; Kirchhoff, Tomas

Cancer immunology immunotherapy. 2019 Jun; 68(6):897-905

Bedognetti, Davide; Ceccarelli, Michele; Galluzzi, Lorenzo; Lu, Rongze; Palucka, Karolina; Samayoa, Josue; Spranger, Stefani; Warren, Sarah; Wong, Kwok-Kin; Ziv, Elad; Chowell, Diego; Coussens, Lisa M; De Carvalho, Daniel D; DeNardo, David G; Galon, Jérôme; Kaufman, Howard L; Kirchhoff, Tomas; Lotze, Michael T; Luke, Jason J; Minn, Andy J; Politi, Katerina; Shultz, Leonard D; Simon, Richard; Thórsson, Vésteinn; Weidhaas, Joanne B; Ascierto, Maria Libera; Ascierto, Paolo Antonio; Barnes, James M; Barsan, Valentin; Bommareddy, Praveen K; Bot, Adrian; Church, Sarah E; Ciliberto, Gennaro; De Maria, Andrea; Draganov, Dobrin; Ho, Winson S; McGee, Heather M; Monette, Anne; Murphy, Joseph F; Nisticò, Paola; Park, Wungki; Patel, Maulik; Quigley, Michael; Radvanyi, Laszlo; Raftopoulos, Harry; Rudqvist, Nils-Petter; Snyder, Alexandra; Sweis, Randy F; Valpione, Sara; Butterfield, Lisa H; Disis, Mary L; Fox, Bernard A; Cesano, Alessandra; Marincola, Francesco M

Journal for immunotherapy of cancer. 2019 May 22; 7(1):131

Lattanzi, Michael; Lee, Yesung; Simpson, Danny; Moran, Una; Darvishian, Farbod; Kim, Randie H; Hernando, Eva; Polsky, David; Hanniford, Doug; Shapiro, Richard; Berman, Russell; Pavlick, Anna C; Wilson, Melissa A; Kirchhoff, Tomas; Weber, Jeffrey S; Zhong, Judy; Osman, Iman

Journal of the National Cancer Institute. 2019 Feb 01; 111(2):180-188