Tomas Kirchhoff, PhD

Perlmutter Cancer Center

Associate Professor, Department of Population Health

Associate Professor, Department of Environmental Medicine

cancer, computational biology, epidemiology, genomics

The primary interest of my laboratory is focused on the identification of the genetic basis of cancer susceptibility. A key question in these efforts is how the germline genetic events contributing to predisposition of human cancers interact mutually in particular molecular pathways or in concert with the environmental exposures. Specifically, our ongoing studies aim at identification of the genetic variants conferring an increased risk to common cancers, such as breast, colon, prostate cancers or lymphoma, focusing on the relevant molecular pathways. These studies combine the genome-wide association analysis (GWAS), high-throughput genotyping and most recently the next-generation sequencing in large case/control populations. The significant aspect of my current and future research is an integration of the information from somatic genetics in tumors to complement the germline findings. We believe that such integration of biological data will be beneficial not only for improved prevention strategies but most importantly for the future development of the targeted personalized therapies.



Academic office

522 First Avenue

Twelfth Floor

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication

Associate Professor, Department of Population Health

Associate Professor, Department of Environmental Medicine

Inman, C K; Aljunaibi, A; Koh, H; Abdulle, A; Ali, R; Alnaeemi, A; Al, Zaabi E; Oumeziane, N; Al, Bastaki M; Al-Houqani, M; Al-Maskari, F; Al, Dhaheri A; Shah, S M; Abdel, Wareth L; Al, Mahmeed W; Alsafar, H; Al, Anouti F; Al, Hosani A; Haji, M; Galani, D; O'Connor, M J; Ahn, J; Kirchhoff, T; Sherman, S; Hayes, R B; Li, H; Ramasamy, R; Schmidt, A M

Journal of clinical & translational endocrinology. 2017 December; 10(pp):1-8

Germline determinants of immune related adverse events (irAEs) in melanoma immunotherapy response [Meeting Abstract]

Kirchhoff, T; Ferguson, R; Simpson, D; Kazlow, E; Martinez, C; Vogelsang, M; Wilson, M; Pavlick, AC; Weber, JS; Osman, I

Annals of oncology. 2017 SEP; 28:?-?

Blazer, Ashira; Wang, Binhuan; Simpson, Danny; Kirchhoff, Tomas; Heffron, Sean; Clancy, Robert M; Heguy, Adriana; Ray, Karina; Snuderl, Matija; Buyon, Jill P

PLoS one. 2017 Aug 29; 12(8):e0182483-e0182483e0182483

Mutation burden as a potential prognostic marker of melanoma progression and survival [Meeting Abstract]

Simpson, D; Ferguson, R; Martinez, C N; Kazlow, E; Moran, U; Heguy, A; Hanniford, D; Hernando, E; Osman, I; Kirchhoff, T

Journal of clinical oncology. 2017 Jun 20; Conference:(2017):

Primary melanoma histologic subtype (HS) impacts melanoma specific survival (MSS) and response to systemic therapy [Meeting Abstract]

Lattanzi, M; Lee, Y; Robinson, E M; Weiss, S A; Moran, U; Simpson, D; Shapiro, R L; Berman, R S; Pavlick, A C; Wilson, M; Kirchhoff, T; Zhong, J; Osman, I

Journal of clinical oncology. 2017 Jun 20; Conference:(2017):

Ferguson, Robert; Vogelsang, Matjaz; Ucisik-Akkaya, Esma; Rai, Karan; Pilarski, Robert; Martinez, Carlos N; Rendleman, Justin; Kazlow, Esther; Nagdimov, Khagay; Osman, Iman; Klein, Robert J; Davidorf, Frederick H; Cebulla, Colleen M; Abdel-Rahman, Mohamed H; Kirchhoff, Tomas

Scientific reports. 2016 Aug 08; 6:31191-31191

Vogelsang, Matjaz; Martinez, Carlos N; Rendleman, Justin; Bapodra, Anuj Bapodra; Malecek, Karolina; Romanchuk, Artur; Kazlow, Esther; Shapiro, Richard L; Berman, Russell S; Krogsgaard, Michelle; Osman, Iman; Kirchhoff, Tomas

Clinical cancer research. 2016 Jul 01; 22(13):3268-3280

Pires Silva, Ines; Salhi, Amel; Giles, Keith M; Vogelsang, Matjaz; Han, Sung Won; Ismaili, Naima; Lui, Kevin P; Robinson, Eric M; Wilson, Melissa A; Shapiro, Richard L; Pavlick, Anna; Zhong, Judy; Kirchhoff, Tomas; Osman, Iman

Clinical cancer research. 2016 May 15; 22(10):2377-2385