Tony T. Huang

Tony T. Huang

Associate Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
regulation of ubiquitination and deubiquitination in DNA repair and cancer susceptibility pathways, genome integrity, pharmacology
Summary

Ubiquitination is a highly regulated process conserved in all eukaryotes that controls a broad range of cellular functions, from proteolysis, signal transduction, endocytosis, to DNA repair and genomic stability. Like phosphorylation, ubiquitination can be a dynamic and reversible post-translational process whereby an enzyme cascade conjugates ubiquitin to a target protein, and a family of proteases, the deubiquitinating enzymes (DUBs), are potent at removing this modification. Our lab studies two important DNA damage response pathways that are "switched on" by non-proteolytic ubiquitination events: the Fanconi Anemia (FA) DNA cross-link repair and genome stability pathway, and the DNA damage tolerance translesion synthesis pathway (TLS). While the elucidation of upstream activators of diverse DNA damage response pathways remains to be the focus of the field, signal transduction events that "switch off" DNA repair have been largely ignored. To begin addressing this issue, a major focus of my lab will be to study the action of DUBs in the context of DNA repair pathways. In humans, protein deubiquitination is controlled by a family of over 90 distinct DUB enzymes, of which the majority has not been functionally characterized. We utilized a gene family-specific siRNA library to identify DUBs that negatively regulate different aspects of DNA repair and genome stability pathways in human cells. Research projects in my lab will include the characterization and elucidation of signaling mechanisms surrounding DUB activation and inactivation and how these molecular events function to confer genomic stability in normal versus cancerous cells.

Phone

212-263-9046

Fax

212-263-8166

Academic office

550 First Avenue, Medical Science Bldg.

3, 399

New York, NY 10016

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Associate Professor, Department of Biochemistry and Molecular Pharmacology

Director, Protein Modifications of Disease Module

Graduate Advisor, Molecular Oncology and Tumor Immunology Training Program

Coleman, Kate E; Huang, Tony T

EMBO reports. 2016 Jun; 17(6):781-782

Bekes, Miklos; van der Heden van Noort, Gerbrand J; Ekkebus, Reggy; Ovaa, Huib; Huang, Tony T; Lima, Christopher D

Molecular cell. 2016 May 19; 62(4):572-585

Coleman, Kate E; Huang, Tony T

Frontiers in genetics. 2016; 7:61-61

Kee, Younghoon; Huang, Tony T

Molecular & cellular biology. 2015 Dec 07; 36(4):524-544

Chen, Yu-Hung; Jones, Mathew J K; Yin, Yandong; Crist, Sarah B; Colnaghi, Luca; Sims, Robert J 3rd; Rothenberg, Eli; Jallepalli, Prasad V; Huang, Tony T

Molecular cell. 2015 Apr 16; 58(2):323-338

Karttunen, Heidi; Savas, Jeffrey N; McKinney, Caleb; Chen, Yu-Hung; Yates, John R 3rd; Hukkanen, Veijo; Huang, Tony T; Mohr, Ian

Molecular cell. 2014 Jul 03; 55(1):111-122

Bekes, Miklos; Okamoto, Keiji; Crist, Sarah B; Jones, Mathew J; Chapman, Jessica R; Brasher, Bradley B; Melandri, Francesco D; Ueberheide, Beatrix M; Lazzerini Denchi, Eros; Huang, Tony T

Cell reports. 2013 Nov 14; 5(3):826-838

Piatkov, Konstantin I; Colnaghi, Luca; Bekes, Miklos; Varshavsky, Alexander; Huang, Tony T

Molecular cell. 2012 Dec 28; 48(6):926-933