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Tony T. Huang

Tony T. Huang, PhD

Associate Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
Ubiquitin regulation and signaling in cancer, Genome integrity, Replication stress, Neuronal DNA repair, Fanconi Anemia
Summary

One of our major research goals is to elucidate the molecular pathogenesis of the Fanconi Anemia DNA repair and cancer susceptibility pathway and how it interfaces with environmental factors.  Over the last decade, research groups, including our lab, have carefully defined and pinpointed the critical genes that are mutated in patients with the Fanconi Anemia (FA) disease.  However, it is still unclear how FA proteins and protein complexes in this pathway can work together to alleviate defects in patient cells, such as hypersensitivity to DNA crosslinking agents, replication stress, increased apoptosis, genomic instability, and cellular transformation.  My long-standing track record of publications and expertise in the field of Fanconi Anemia, ubiquitin signaling and DNA repair have positioned me with a unique advantage to tackle some of these extraordinary biological problems related to genome integrity and human disease.  In the past, we have successfully identified and characterized new FA and FA-related genes whose gene products are activated by ubiquitination and deubiquitination. DNA repair and replication stress response pathways, such as the FA pathway, are critical in preventing chromosomal instability and tumorigenesis. Concerted research efforts from our research group will strive to elucidate new mechanisms that will lead to deeper understanding of how endogenous and environmental factors can influence the FA disease, with the goal of identifying new targets for therapeutic intervention.

Another major research goal involves understanding how deubiquitinating enzymes (DUBs) are regulated under different environmentally-related and physiological conditions (normal vs cancer cells) to cleave monoubiquitinated and/or polyubiquitinated protein substrates. How DUBs are able to discriminate between different substrates or ubiquitin chain types is an emerging area of study, especially in the design of novel inhibitors for cancer therapy and personalized medicine.

Phone

212-263-9046

Fax

212-263-8166

Academic office

550 First Avenue, Medical Science Bldg.

3, 399

New York, NY 10016

Lab Website
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Associate Professor, Department of Biochemistry and Molecular Pharmacology

Course Director, Protein Modifications in Cell Signaling

Graduate Advisor, Molecular Oncology and Tumor Immunology Training Program

PhD from University of Wisconsin

Dana-Farber Cancer Institute, Alan D'Andrea Lab

Hu, Hui-Lan; Shiflett, Lora A; Kobayashi, Mariko; Chao, Moses V; Wilson, Angus C; Mohr, Ian; Huang, Tony T

Molecular cell. 2019 May 02; 74(3):466-480.e4

Chen, Yu-Hung; Keegan, Sarah; Kahli, Malik; Tonzi, Peter; Fenyö, David; Huang, Tony T; Smith, Duncan J

Nature structural & molecular biology. 2019 Jan; 26(1):67-77

Tonzi, Peter; Yin, Yandong; Lee, Chelsea Wei Ting; Rothenberg, Eli; Huang, Tony T

eLife. 2018 11 13; 7:

Ma, Li; Lin, Kangyu; Chang, Guoqiang; Chen, Yiwen; Yue, Chen; Guo, Qing; Zhang, Sicong; Jia, Zhiliang; Huang, Tony T; Zhou, Aidong; Huang, Suyun

Cancer research. 2019 Jan 01; 79:72-85

Coleman, Kate E; Bekes, Miklos; Chapman, Jessica R; Crist, Sarah B; Jones, Mathew Jk; Ueberheide, Beatrix M; Huang, Tony T

eLife. 2017 05 05; 6:

Bekes, Miklos; van der Heden van Noort, Gerbrand J; Ekkebus, Reggy; Ovaa, Huib; Huang, Tony T; Lima, Christopher D

Molecular cell. 2016 05 19; 62(4):572-85

Chen, Yu-Hung; Jones, Mathew J K; Yin, Yandong; Crist, Sarah B; Colnaghi, Luca; Sims, Robert J 3rd; Rothenberg, Eli; Jallepalli, Prasad V; Huang, Tony T

Molecular cell. 2015 Apr 16; 58(2):323-38