We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using a variety of techniques, including patch clamping, biochemistry, and genetically engineered mouse models, we investigate the roles of the KATP channel in cardioprotection and the regulation of blood flow. In collaboration with the New York City Office of the Chief Medical Examiner, Dr. Coetzee's laboratory also investigates genetic variation of ion channel genes in sudden unexplained death.
Professor, Department of Pediatrics
Professor, Department of Biochemistry and Molecular Pharmacology
Professor, Department of Neuroscience and Physiology
Director of Research
Physiological reviews. 2016 Jan; 96(1):177-252
Pathobiology of aging & age related diseases. 2016; 6:32517-32517
Diabetes. 2018 Feb 12; ?-?
FASEB journal. 2018 Jan 3; fj201700027R-fj201700027R
Circulation: Cardiovascular genetics. 2017 Dec; 10(6):
Nature communications. 2017 Jul 24; 8(1):106-106
Pacing & clinical electrophysiology. 2017 May 16; 40(6):703-712
American journal of physiology. Heart & circulatory physiology. 2016 Jun 01; 310(11):H1558-H1566ajpheart.00158.2016