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William A. Coetzee

William A. Coetzee

Professor, Department of Pathology

Professor, Department of Biochemistry and Molecular Pharmacology

Professor, Department of Neuroscience and Physiology

Professor, Department of Pediatrics

Keywords
Electrophysiology and molecular biology of cardiovascular membrane ion transport proteins, Ion channels and transporters, ATP-sensitive potassium channels, Biophysics, Cardiovascular biology, Ischemia and Ischemic Preconditioning, Excitation-contraction coupling
Summary

We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using a variety of techniques, including patch clamping, biochemistry, and genetically engineered mouse models, we investigate the roles of the KATP channel in cardioprotection and the regulation of blood flow. In collaboration with the New York City Office of the Chief Medical Examiner, Dr. Coetzee's laboratory also investigates genetic variation of ion channel genes in sudden unexplained death. 

Phone

646-501-4510

Academic office

435 East 30th Street, Science Building

Floor 4, 412

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.
Foster, Monique N; Coetzee, William A

Physiological reviews. 2016 Jan; 96(1):177-252

Yang, Hua-Qian; Subbotina, Ekaterina; Ramasamy, Ravichandran; Coetzee, William A

Pathobiology of aging & age related diseases. 2016 10; 6:32517

Aykut, Berk; Chen, Ruonan; Kim, Jacqueline I; Wu, Dongling; Shadaloey, Sorin A A; Abengozar, Raquel; Preiss, Pamela; Saxena, Anjana; Pushalkar, Smruti; Leinwand, Joshua; Diskin, Brian; Wang, Wei; Werba, Gregor; Berman, Matthew; Lee, Steve Ki Buom; Khodadadi-Jamayran, Alireza; Saxena, Deepak; Coetzee, William A; Miller, George

Science immunology. 2020 08 21; 5(50):

Yang, Hua-Qian; Martinez-Ortiz, Wilnelly; Hwang, JongIn; Fan, Xuexin; Cardozo, Timothy J; Coetzee, William A

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2020 May 12; 117(19):10593-10602

Gando, Ivan; Campana, Chiara; Tan, Reina Bianca; Cecchin, Frank; Sobie, Eric A; Coetzee, William A

Journal of molecular & cellular cardiology. 2020 Apr 24; 144:1-11

Yang, Hua-Qian; Pérez-Hernández, Marta; Sanchez-Alonso, Jose; Shevchuk, Andriy; Gorelik, Julia; Rothenberg, Eli; Delmar, Mario; Coetzee, William A

eLife. 2020 Jan 14; 9:

Ankyrin-G mediates targeting of both Na<sup>+</sup> and K<inf>ATP</inf> channels to the rat cardiac intercalated disc

Yang, H -Q; Perez-Hernandez, M; Sanchez-Alonso, J; Shevchuk, A; Gorelik, J; Rothenberg, E; Delmar, M; Coetzee, W A

eLife. 2020 January; 9:

Gando, Ivan; Yang, Hua-Qian; Coetzee, William A

Forensic science, medicine, & pathology. 2019 Sep; 15(3):437-444