William A. Coetzee

William A. Coetzee

Professor, Department of Pediatrics

Professor, Department of Biochemistry and Molecular Pharmacology

Professor, Department of Neuroscience and Physiology

Keywords
Electrophysiology and molecular biology of cardiovascular membrane ion transport proteins, Ion channels and transporters, ATP-sensitive potassium channels, Biophysics, Cardiovascular biology, Ischemia and Ischemic Preconditioning, Excitation-contraction coupling
Summary

We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using a variety of techniques, including patch clamping, biochemistry, and genetically engineered mouse models, we investigate the roles of the KATP channel in cardioprotection and the regulation of blood flow. In collaboration with the New York City Office of the Chief Medical Examiner, Dr. Coetzee's laboratory also investigates genetic variation of ion channel genes in sudden unexplained death. 

Phone

646-501-4510

Fax

212-263-5100

Academic office

Alexandria Center, 450 East 29th Street

Floor 8, 824

New York, NY 10016

Is this your profile?
These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
Loading...

Professor, Department of Pediatrics

Professor, Department of Biochemistry and Molecular Pharmacology

Professor, Department of Neuroscience and Physiology

Director of Research

Foster, Monique N; Coetzee, William A

Physiological reviews. 2016 Jan; 96(1):177-252

Yang, Hua-Qian; Subbotina, Ekaterina; Ramasamy, Ravichandran; Coetzee, William A

Pathobiology of aging & age related diseases. 2016; 6:32517-32517

Srivastava, Shekhar; Li, Zhai; Soomro, Irfana; Sun, Ying; Wang, Jianhui; Bao, Li; Coetzee, William A; Stanley, Charles A; Li, Chonghong; Skolnik, Edward Y

Diabetes. 2018 May 15; 67(5):849-860

Yang, Hua Qian; Jana, Kundan; Rindler, Michael J; Coetzee, William A

FASEB journal. 2018 Mar 15; 32(3):1613-1625

Population-Based Mathematical Modeling to Deduce Disease-Causing Cardiac Na+ Channel Gating Defects [Meeting Abstract]

Campana, Chiara; Gando, Ivan; Tan, Reina Bianca; Cecchin, Frank; Coetzee, William A.; Sobie, Eric A.

Biophysical journal. 2018 FEB 2; 114:634A-635A

Lin, Ying; Williams, Nori; Wang, Dawei; Coetzee, William; Zhou, Bo; Eng, Lucy S; Um, Sung Yon; Bao, Ruijun; Devinsky, Orrin; McDonald, Thomas V; Sampson, Barbara A; Tang, Yingying

Circulation: Cardiovascular genetics. 2017 Dec; 10(6):

Cerrone, Marina; Montnach, Jerome; Lin, Xianming; Zhao, Yan-Ting; Zhang, Mingliang; Agullo-Pascual, Esperanza; Leo-Macias, Alejandra; Alvarado, Francisco J; Dolgalev, Igor; Karathanos, Thomas V; Malkani, Kabir; Van Opbergen, Chantal J M; van Bavel, Joanne J A; Yang, Hua-Qian; Vasquez, Carolina; Tester, David; Fowler, Steven; Liang, Fengxia; Rothenberg, Eli; Heguy, Adriana; Morley, Gregory E; Coetzee, William A; Trayanova, Natalia A; Ackerman, Michael J; van Veen, Toon A B; Valdivia, Hector H; Delmar, Mario

Nature communications. 2017 Jul 24; 8(1):106-106

Gando, Ivan; Morganstein, Jace; Jana, Kundan; McDonald, Thomas V; Tang, Yingying; Coetzee, William A

Pacing & clinical electrophysiology. 2017 May 16; 40(6):703-712