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William A. Coetzee

William A. Coetzee

Professor, Department of Pathology

Professor, Department of Biochemistry and Molecular Pharmacology

Professor, Department of Neuroscience and Physiology

Professor, Department of Pediatrics

Electrophysiology and molecular biology of cardiovascular membrane ion transport proteins, Ion channels and transporters, ATP-sensitive potassium channels, Biophysics, Cardiovascular biology, Ischemia and Ischemic Preconditioning, Excitation-contraction coupling

We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using a variety of techniques, including patch clamping, biochemistry, and genetically engineered mouse models, we investigate the roles of the KATP channel in cardioprotection and the regulation of blood flow. In collaboration with the New York City Office of the Chief Medical Examiner, Dr. Coetzee's laboratory also investigates genetic variation of ion channel genes in sudden unexplained death. 



Academic office

522 1st Avenue

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.
Foster, Monique N; Coetzee, William A

Physiological reviews. 2016 Jan; 96(1):177-252

Yang, Hua-Qian; Subbotina, Ekaterina; Ramasamy, Ravichandran; Coetzee, William A

Pathobiology of aging & age related diseases. 2016 10; 6:32517

Yang, Bo; Yao, Jia-Lu; Huo, Jian-Yi; Feng, Yu-Long; Coetzee, William A; Xu, Guang-Yin; Yang, Hua-Qian

Channels (Austin, Tex.). 2022 12; 16(1):137-147

Yang, Hua-Qian; Echeverry, Fabio A; ElSheikh, Assmaa; Gando, Ivan; Anez Arredondo, Sophia; Samper, Natalie; Cardozo, Timothy; Delmar, Mario; Shyng, Show-Ling; Coetzee, William A

American journal of physiology. Cell physiology. 2022 Jun 01; 322(6):C1230-C1247

Concepcion, Axel R; Wagner, Larry E 2nd; Zhu, Jingjie; Tao, Anthony Y; Yang, Jun; Khodadadi-Jamayran, Alireza; Wang, Yin-Hu; Liu, Menghan; Rose, Rebecca E; Jones, Drew R; Coetzee, William A; Yule, David I; Feske, Stefan

Nature immunology. 2022 Feb; 23(2):287-302

Aykut, Berk; Chen, Ruonan; Kim, Jacqueline I; Wu, Dongling; Shadaloey, Sorin A A; Abengozar, Raquel; Preiss, Pamela; Saxena, Anjana; Pushalkar, Smruti; Leinwand, Joshua; Diskin, Brian; Wang, Wei; Werba, Gregor; Berman, Matthew; Lee, Steve Ki Buom; Khodadadi-Jamayran, Alireza; Saxena, Deepak; Coetzee, William A; Miller, George

Science immunology. 2020 Aug 21; 5(50):

Yang, Hua-Qian; Martinez-Ortiz, Wilnelly; Hwang, JongIn; Fan, Xuexin; Cardozo, Timothy J; Coetzee, William A

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2020 May 12; 117(19):10593-10602

Gando, Ivan; Campana, Chiara; Tan, Reina Bianca; Cecchin, Frank; Sobie, Eric A; Coetzee, William A

Journal of molecular & cellular cardiology. 2020 Apr 24; 144:1-11