Professor, Department of Pathology
Professor, Department of Biochemistry and Molecular Pharmacology
Professor, Department of Neuroscience and Physiology
Professor, Department of Pediatrics
We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using a variety of techniques, including patch clamping, biochemistry, and genetically engineered mouse models, we investigate the roles of the KATP channel in cardioprotection and the regulation of blood flow. In collaboration with the New York City Office of the Chief Medical Examiner, Dr. Coetzee's laboratory also investigates genetic variation of ion channel genes in sudden unexplained death.
Physiological reviews. 2016 Jan; 96(1):177-252
Pathobiology of aging & age related diseases. 2016 10; 6:32517
American journal of physiology. Cell physiology. 2023 May 01; 324(5):C1017-C1027
Frontiers in pharmacology. 2023 Jan 01; 14:?-?
Frontiers in pharmacology. 2023 Jun; 14:1197257
Channels (Austin, Tex.). 2022 12; 16(1):137-147
American journal of physiology. Cell physiology. 2022 Jun 01; 322(6):C1230-C1247
Nature immunology. 2022 Feb; 23(2):287-302