William A. Coetzee, ScD

We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using a variety of techniques, including patch clamping, biochemistry, and genetically engineered mouse models, we investigate the roles of the KATP channel in cardioprotection and the regulation of blood flow. In collaboration with the New York City Office of the Chief Medical Examiner, Dr. Coetzee's laboratory also investigates genetic variation of ion channel genes in sudden unexplained death.