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Zhe S. Chen

Zhe S. Chen, PhD

Associate Professor, Department of Psychiatry

Associate Professor, Department of Neuroscience and Physiology

integration of computational and experimental techniques to dissect neural circuits and neural population codes, computational neuroscience, neural engineering, computational statistics, machine learning, computational psychiatry, behavior modeling

Our current research focuses on combining multidisciplinary techniques: electrophysiology, computational modeling of circuits and behavior,  statistical analysis of neural data, and neural engineering to investigate basic and translational neuroscience questions, and to address challenging data analytic problems in neuropsychiatric clinical research.

In collaboration with experimental neuroscientists, we are working on several exciting projects: learning and memory associated with hippocampal-cortical circuits; thalamocortical and cortico-thalamic circuits in working memory and executive control; and, real-time brain-machine interface for pain circuits and memory circuits.



Academic office

One Park Avenue

Eighth Floor, Rm 226

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

Director, Computational Psychiatry Research Program

PhD from McMaster University

Harvard Medical School, Neuroscience Statistics Research Lab

Sun, Guanghao; Zeng, Fei; McCartin, Michael; Zhang, Qiaosheng; Xu, Helen; Liu, Yaling; Chen, Zhe Sage; Wang, Jing

Science translational medicine. 2022 Jun 29; 14(651):eabm5868

Xue, Xiaohe; Wimmer, Ralf D.; Halassa, Michael M.; Chen, Zhe Sage

Cognitive computation. 2022 Jan 01; ?-?

Chen, Zhe Sage

Journal of neural engineering. 2021 Oct 04; 18(5):

Long, Xiaoyang; Deng, Bin; Young, Calvin K; Liu, Guo-Long; Zhong, Zeqi; Chen, Qian; Yang, Hui; Lv, Sheng-Qing; Chen, Zhe Sage; Zhang, Sheng-Jia

Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022 Mar 17; e2200020

Qi, Wei; Wen, Zhenfu; Chen, Jingyun; Capichioni, Gillian; Ando, Fumika; Chen, Zhe Sage; Wang, Jijun; Yoncheva, Yuliya; Castellanos, Francisco X; Milad, Mohammed; Goff, Donald C

Schizophrenia research. 2023 Sep 14; 261:100-106

Liu, Yaling; Li, Anna; Bair-Marshall, Chloe; Xu, Helen; Jee, Hyun Jung; Zhu, Elaine; Sun, Mengqi; Zhang, Qiaosheng; Lefevre, Arthur; Chen, Zhe Sage; Grinevich, Valery; Froemke, Robert C; Wang, Jing

Neuron. 2023 Jun 07; 111(11):1795-1811.e7

Seymour, Ben; Crook, Robyn J; Chen, Zhe Sage

Nature reviews. Neuroscience. 2023 Jun; 24(6):378-392