Fellowship Training: Research

It is expected that all fellows will engage in research. Although formally this will begin in year 2, fellows will be encouraged to identify a mentor and begin their projects during year 1. Moreover, the division is committed to providing a third year of fellowship, which will be dedicated to additional research time, for all incoming fellows.

In preparation for determining an area of interest and choice of laboratory and mentor, each trainee meets with the program director early in the spring of first year. The program director takes an active role in ensuring that the selections of the trainees, including choice of laboratory and project, are made wisely and in a timely manner. During their research experience, fellows are expected to present their research in a seminar format, and, if they have accomplished a body of work, to present that work at national meetings and/or assist in its preparation for publication.

Research in endocrinology, diabetes and metabolic disease takes many forms and we encourage fellows to follow their interests. If they so choose, projects in basic science, population sciences, or translational studies that are outside of the divisional or departmental expertise will be supported.

Several key faculty members of the Division of Endocrinology and Metabolism are active in grant-supported bench research. These include Drs. David Kleinberg, Ira J. Goldberg, Ravichandran Ramasamy, and Ann Marie Schmidt.

Drs. Manfred Blum, Loren Greene, and Valerie Peck also have undertaken substantial, ongoing, patient-related clinical research. Their areas of particular interest include imaging of thyroid and parathyroid lesions, adrenal insufficiency in patients with AIDS, and diagnostic and therapeutic approaches to osteoporosis.

Within the division, research strengths include laboratory studies of diabetes and lipid metabolism. NYULMC boasts one of the world’s strongest programs in complications of diabetes. Studies in the Diabetes Research Center include advanced glycation end products, aldose reducatase, and the effect of diabetes on white blood cell function. The causes of greater cardiovascular disease (coronary artery disease and heart failure) are a focus of several laboratories.

There are also endocrine research opportunities at NYU College of Dentistry in the Center for Skeletal and Craniofacial Biology, led by Dr. Nicola Partridge. The center was established in 2012 with funding from the NIH, and aims to increase the profile of research pertaining to craniofacial development and bone—including cleft palate and bone loss related to osteoporosis, kidney failure, cancer metastasis, and periodontal disease. Dr. Partridge's research focuses on parathyroid hormone (PTH) regulation of gene expression by the osteoblast. The center is also home to Dr. Shoshana Yakar, whose research focuses on understanding the role(s) of insulin-like growth factors (IGFs) in tissue growth, development and repair. In particular, this work has dealt with the question of distinguishing paracrine effects of locally produced IGF from endocrine effects of circulating IGF synthesized primarily by the liver.

Translational studies of patients with immunological causes of endocrine diseases are being performed in the Blaser Laboratory, one of the foremost laboratories in microbiome research. In addition, investigators in Population Health study complications that arise in diverse groups of patients. Fellows may also participate in a number of clinical projects on new drug development, treatment complications, and novel genetic methods to predict the prognosis of thyroid cancers.

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