Agueda A. Rostagno, Ph.D.

Agueda A. Rostagno, Ph.D.
Associate Professor of Pathology
Training Faculty, Primary Mentor, Pathobiology and Translational Medicine Training Program
Experimental Pathology, Immunology, Pathobiology / Cerebrovascular amyloidosis; cerebral hemorrhage; dementia

Agueda.Rostagno@nyumc.org, (212) 263 7724
Fax: (212) 263 0858
550 First Avenue, MSB 556, New York, NY 10016

 

Research and Clinical Interests

Dr. Rostagno has a long-standing interest in the molecular pathogenesis of cerebrovascular amyloidosis, particularly in the role of vascular amyloid in the processes of cerebral hemorrhage and dementia. Current projects involve the dissection of the structure-function relationship of different amyloid assemblies in the induction of cell-signaling pathways detrimental for the physiologic integrity of the neurovascular unit through an array of physicochemical, proteomic and genomic approaches.

Selected Publications

Hernandez-Guillamon M, Mawhirt S, Fossati S, Blais S, Pares M, Penalba A, Boada M, Couraud PO, Neubert TA, Montaner J, Ghiso J, Rostagno A. Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells. J Biol Chem. 2010 Aug 27;285(35):27144-58. Epub 2010 Jun 24. Cited in Pubmed; PMID 20576603. doi: 10.1074/jbc.M110.135228. PMCID: PMC2930713.

Tomidokoro Y, Rostagno A, Neubert TA, Lu Y, Rebeck GW, Frangione B, Greenberg SM, Ghiso J. Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid deposits. Am J Pathol. 2010 Apr;176(4):1841-54. Epub 2010 Mar 12. Cited in Pubmed; PMID 20228223. doi: 10.2353/ajpath.2010.090636. PMCID: PMC2843474.

Solito R, Corti F, Fossati S, Mezhericher E, Donnini S, Ghiso J, Giachetti A, Rostagno A, Ziche M. Dutch and arctic mutant peptides of beta amyloid (1-40) differentially affect the FGF-2 pathway in brain endothelium. Exp Cell Res. 2009 Feb 1;315(3):385-95. Epub 2008 Nov 19. Cited in Pubmed; PMID 19061884. doi:doi:10.1016/j.yexcr.2008.11.002.

Tsachaki M, Ghiso J, Rostagno A, Efthimiopoulos S. BRI2 homodimerizes with the involvement of intermolecular disulfide bonds. Neurobiol Aging. 2008 Apr;Epub 2008 Apr 24. Cited in Pubmed; PMID 18440095. doi:10.1016/j.neurobiolaging.2008.03.004.

Rostagno A, Lashley T, Ng D, Meyerson J, Braendgaard H, Plant G, Bojsen-Moller M, Holton J, Frangione B, Revesz T, Ghiso J. Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: similarities with Alzheimer's disease. J Neurol Sci. 2007 Jun 15;257(1-2):88–96. Cited in Pubmed; PMID 17374542.

Rostagno A*, Ovodenko B*, Neubert TA, Shetty V, Thomas S, Yang A, Liebmann J, Ghiso J, Ritch R. Proteomic analysis of exfoliation deposits. Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1447–57. Cited in Pubmed; PMID 17389470.

Ghiso J, Rostagno A, Tomidokoro Y, Lashley T, Bojsen-Møller M, Braendgaard H, Plant G, Holton J, Lal R, Revesz T, Frangione B. Genetic alterations of the BRI2 gene: familial British and Danish dementias. Brain Pathol. 2006 Jan;16(1):71-9. Cited in Pubmed; PMID 16612984.

Tomidokoro Y, Lashley T, Rostagno A, Neubert TA, Bojsen-Moller M, Braendgaard H, Plant G, Holton J, Frangione B, Revesz T, Ghiso J. Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan and Aβ) in the absence of compact plaques. J Biol Chem. 2005 Nov 4;280(44):36883–94. Cited in Pubmed; PMID 16091362.

Fotinopoulou A, Tsachaki M, Vlavaki M, Poulopoulos A, Rostagno A, Frangione B, Ghiso J, Efthimiopoulos S. BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Aβ) production. J Biol Chem. 2005 Sep 2;280(35):30768-72. Epub 2005 Jul 18. Cited in Pubmed; PMID 16027166.

Rostagno A, Tomidokoro Y, Lashley T, Ng D, Plant G, Holton J, Frangione B, Revesz T, Ghiso J. Chromosome 13 dementias. Cell Mol Life Sci. 2005 Aug;62(16):1814–25. Cited in Pubmed; PMID 15968464.

Ghiso J, Shayo M, Calero M, Ng D, Tomidokoro Y, Gandy S, Rostagno A, Frangione B. Systemic catabolism of Alzheimer's Abeta40 and Abeta42. J Biol Chem. 2004 Oct 29;279(44):45897-908. Epub 2004 Aug 20. Cited in Pubmed; PMID 15322125.

Rostagno A, Revesz T, Lashley T, Tomidokoro Y, Magnotti L, Braendgaard H, Plant G, Bojsen-Moller M, Holton J, Frangione B, Ghiso J. Complement activation in chromosome 13 dementias. Similarities with Alzheimer's disease. J Biol Chem. 2002 Dec 20;277(51):49782–90. Cited in Pubmed; PMID 1238855.

Rostagno AA, Gallo G, Gold LI. Binding of polymeric IgG to fibronectin in extracellular matrices: an in vitro paradigm for immune-complex deposition. Mol Immunol. 2002 Jun;38(15):1101–11. Cited in Pubmed; PMID 12044777.

Vidal R, Revesz T, Rostagno A, Kim E, Holton JL, Bek T, Bojsen-Moller M, Braendgaard H, Plant G, Ghiso J, Frangione B. A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4920–5. Cited in Pubmed; PMID 10781099.

Vidal R, Frangione B, Rostagno A, Mead S, Revesz T, Plant G, Ghiso J. A stop-codon mutation in the BRI gene associated with familial British dementia. Nature. 1999 Jun 24;399(6738):776–81. Cited in Pubmed; PMID 10391242.

Selected Books

Rostagno A, Ghiso J. Chapter 11: Hereditary forms of cerebrovascular amyloidosis. In: Wahlund LO, Erkinjuntti T, Gauthier S, editors. Vascular cognitive impairment in clinical practice. Cambridge, UK: Cambridge University Press; 2009. pp. 139-54.

Cam J, Meyerson J, E. Mezhericher, Frangione B, Ghiso J, Rostagno A. Differential apoptotic response of primary human cerebral endothelial cells to oligomeric assemblies of amyloid beta genetic variants. In: Fisher A, Hanin I, Poewe W, Windisch M, editors. New Trends in Alzheimer and Parkinson Disorders. Bologna: Medimond International Proceedings; 2008. pp. 141-6.

Cam J, Meyerson JL, Frangione B, Ghiso J, Rostagno A. Oligomeric assemblies of the Aβ dutch mutant induce the formation of nucleosomes in primary cerebral endothelial cells. In: Iqbal K, Winblad B, Avila J, editors. Alzheimer’s Disease: New Advances. Bologna, Italy: Medimond International Proceedings; 2007. pp. 397–402.

Rostagno A, Lal R, Ghiso J. Protein misfolding, aggregation, and fibril formation: Common features of cerebral and non-cerebral amyloid diseases. In: Dawbarn D, Allen S, editors. The Neurobiology of Alzheimer’s disease. Oxford: Oxford University Press; 2007. pp. 133-60.

Ghiso J, Rostagno A, Tomidokoro Y, Lashley T, Holton JL, Plant G, Revesz T, Frangione B. Familial British and Danish Dementias. Vol. 2. In: Sipe JD, editor. Amyloid Proteins: The β-Sheet Conformation and Disease. Weinheim: Wiley-VCH Verlag; 2005. pp. 515-26.

Revesz T, Ghiso J, Plant G, Lashley T, Rostagno A, Frangione B, Holton JL. International Society for Neuropathology. In: Kalimo H, editor. Cerebrovascular Diseases. Pathology and Genetics. Vol. 5. Basel, Switzerland: International Society for Neuropathology; 2005. pp. 94-102.

Calero M, Rostagno A, Frangione B, Ghiso J. Clusterin and Alzheimer’s disease. In: Harris R, editor. Subcellular Biochemistry: Alzheimer’s Disease. Vol 38. Berlin: Plenum Press / Kluwer; 2005. pp. 273-98.

Rostagno A, Ghiso J. Amyloidosis. In: Aminoff M, Daroff R, editors. Encyclopedia of the Neurological Sciences. Vol 1. San Diego: Academic Press; 2003. pp. 129-35.

Ghiso J, Vidal R, Rostagno A, Mead S, Revesz T, Plant G, Frangione B. A newly formed amyloidogenic fragment due to a stop codon mutation causes familial British dementia. Dementia Rev Series. Vol 3. New York: Informa Healthcare; 2001. pp. 12–3.

Ghiso J, Révész T, Rostagno A, Vidal R, Plant G, Frangione B. Familial British Dementia. In: Iqbal K, Sisodia SS, Wimblad B, editors. Alzheimer’s disease: Advances in Etiology, Pathogenesis and Therapeutics. Chichester, UK: John Wiley & Sons; 2001. pp. 487-94.

Vidal R, Révész T, Rostagno A, Bek T, Braendgaard H, Plant G, Ghiso J, Frangione B. A decamer duplication in the BRI gene originates a de novo amyloid peptide that causes dementia in a Danish kindred. In: Iqbal K, Sisodia SS, Winblad B, editors. Alzheimer’s disease: Advances in etiology, pathogenesis and therapeutics. Chichester, England: John Wiley & Sons; 2001. pp. 507-13.

Ghiso J, Vidal R, Rostagno A, Miravalle L, Holton J, Révész T, Plant G, Frangione B. Amyloidogenesis in Familial British Dementia Is Associated with a Genetic Defect on Chromosome 13. In: Growdon J, Wurtman R, Corkin S, Nitsch, R, editors. The molecular Basis of Dementia. Ann. NY Acad Sci. Vol 920. Malden, MA: Blackwell Publishing Inc; 2000. pp. 84-92.

Ghiso J, Vidal R, Rostagno A, Mead S, Révész T, Plant G, Frangione B. A newly formed amyloidogenic fragment due to a stop codon mutation causes familial British dementia. In: Kalaria R, Ince P, editors. Vascular Factors in Alzheimer’s Disease. Ann NY Acad Sci. Vol 903. Malden, MA: Blackwell Publishing Inc; 2000. pp. 129-37.

Organizational Associations

Society for Neuroscience; The Kunkel Society for Clinical Immunology; The New York Academy of Sciences

Selected Awards

2002 Visiting Fellow, Institute of Neurology, University College of London, United Kingdom
1992-1994 National Kidney Foundation Young Investigator Grant Award
1990-1992 Postdoctoral Fellowship, S.L.E. Foundation, Inc. New York, NY