Acne | NYU Langone Health
Acne is a chronic skin condition characterized by blemishes on the face, chest, and back that can be well managed with noninvasive treatments.
ACNS1833: A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727 IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
Low-grade gliomas (LGG) are the most common central nervous system tumor among children, accounting for approximately one-third of pediatric brain tumors. These tumors include a heterogeneous group of astrocytic, oligodendroglial and mixed glial-neuronal histologies that can occur anywhere in the brain or spinal cord. Although complete surgical resection is the mainstay of therapy whenever feasible, tumors that are unresectable often require additional therapy. Radiation therapy is an effective treatment option for pediatric LGG, but it may result in significant morbidities, including cognitive decline, endocrine deficiencies, secondary malignancies, vascular damage, or growth abnormalities. Since the 1980s, chemotherapy has been used to delay or obviate the need for radiation therapy and reduce the overall therapy-associated morbidity in pediatric LGG. Two commonly used chemotherapy regimens (carboplatin and vincristine [CV] and a combination of thioguanine, procarbazine, lomustine and vincristine [TPCV]) were directly compared in the CCG trial A9952 among children with LGG not associated with neurofibromatosis type 1. CV resulted in a slightly lower 5-year event free survival than TPCV; however, CV avoids the risks of secondary malignancy and infertility posed by the TPCV regimen and remains the most popular chemotherapy regimen with the most robust historical data for children with LGG.Recent advances in our understanding of the biology of pediatric LGG have identified the critical role of activation of the mitogen-activated protein kinase (MAPK) pathway, most commonly due to activation of BRAF through a tandem duplication that results in the KIAA1549-BRAF fusion or an activating BRAF point mutation (BRAFV600E). This discovery has paved the way for the development of drugs that target the MAPK pathway. Selumetinib (AZD6244; ARRY-142886) is a potent, selective, orally-available, non-ATP competitive small molecule inhibitor of MEK-1/2 that lies downstream of BRAF. Phase 1 and phase 2 selumetinib trial data have shown excellent responses and activity in children with multiply recurrent LGG with and without the most common BRAF aberrations. As an alternative to CV, selumetinib may offer reduced cytotoxicity, easier administration (oral) and improved quality of life with the potential for similar or improved efficacy.ACNS1833 is a prospective randomized phase 3 study comparing selumetinib to CV in previously untreated LGG not associated with neurofibromatosis or BRAFV600E. This non-inferiority study will compare event- free survival, functional/behavioral outcomes and quality of life measures for patients treated with CV versus selumetinib.
Acoustic Neuroma | NYU Langone Health
NYU Langone doctors offer surgical and nonsurgical treatments for people who have acoustic neuroma, a type of benign brain tumor.
Active Surveillance of Prostate Cancer | NYU Langone Health
Doctors at NYU Langone’s Perlmutter Cancer Center may recommend active surveillance for some men with slow-growing forms of prostate cancer.
Acute Lymphoblastic Leukemia | NYU Langone Health
NYU Langone specialists work together to diagnose acute lymphoblastic leukemia and develop a customized treatment plan.
Acute Myeloid Leukemia | NYU Langone Health
Perlmutter Cancer Center doctors diagnose and manage acute myeloid leukemia and provide support throughout recovery.
ADAPTATION TO FREQUENCY-PLACE FUNCTIONS IN COCHLEAR IMPLANT USERS
It is a basic study that will examine adaptation to frequency-place maps in cochlear implant users. The main outcome measures will be measures of speech and music perception, sound quality, and sensory acuity.
Addiction | NYU Langone Health
NYU Langone psychiatrists provide counseling to people who have drug or alcohol addictions.
Addressing Ableism through Accommodations for Blindness and Low vision to achieve Equity (AAABLE) in healthcare
This study explores how patients with visual impairments experience and perceive various types of accessibility issues in healthcare as well as the accommodations required to rectify this. This is conducted through virtual semi-structured interviews with patients with visual impairments, caregivers/care partners of individuals with visual impairments receiving healthcare in the US and NYULH healthcare professionals who work with patients who may have visual impairments.
ADDUCTOR CANAL BLOCK PLUS IPACK BLOCK VS ISOLATED ADDUCTOR CANAL BLOCK FOR POSTOPERATIVE ANALGESIA IN HTO/DFO/TTO.
The goal of this study is to compare two different types of nerve blocks for high tibial osteotomy (HTO), distal femoral osteotomy (DFO), or tibial tubercle osteotomy (TTO) procedures. A nerve block is an injection of local anesthetic (numbing) medication into the area surrounding a nerve to decease sensation.